公开(公告)号：US06469216B2

公开(公告)日：2002-10-22

申请号：US09730795

申请日：2000-12-07

Applicant: Gerhard Hillebrand ,  André Hirschauer ,  Dominique Commereuc ,  Hélène Olivier-Bourbigou ,  Lucien Saussine

Inventor： Gerhard Hillebrand ,  André Hirschauer ,  Dominique Commereuc ,  Hélène Olivier-Bourbigou ,  Lucien Saussine

IPC: C07C4550

CPC classification number: C07C45/50 ,  C07C47/02

Abstract: In an improved process for hydroformylation of olefinically unsaturated compounds using a catalyst based on cobalt and/or rhodium employed in a two-phase medium, a catalyst based on cobalt and/or rhodium is used dissolved in a non-aqueous ionic solvent which is liquid at a temperature of less than 90° C., in which the aldehydes formed are slightly soluble or insoluble. More particularly, the catalyst comprises at least one complex of cobalt and/or rhodium co-ordinated with at least one nitrogen-containing ligand and the non-aqueous ionic solvent comprises at least one quaternary ammonium and/or phosphonium cation and at least one inorganic anion. At the end of the reaction, the organic phase is generally separated and the ionic non-aqueous solvent phase containing the catalyst can be re-used.

Abstract translation: 在使用基于在两相介质中使用的钴和/或铑的催化剂的烯属不饱和化合物的加氢甲酰基化的改进方法中，使用基于钴和/或铑的催化剂溶解在非水离子溶剂中，其为液体 在低于90℃的温度下，形成的醛是微溶或不溶的。 更具体地，催化剂包含与至少一种含氮配体配位的至少一种钴和/或铑配合物，非水离子溶剂包含至少一种季铵和/或鏻阳离子和至少一种无机 阴离子 在反应结束时，通常分离有机相，并且可以重新使用含有催化剂的离子非水溶剂相。

公开(公告)号：US06452055B1

公开(公告)日：2002-09-17

申请号：US09700827

申请日：2001-01-05

Applicant: Herbert Koch ,  Reinhard Schomaecker ,  Marco Haumann

Inventor： Herbert Koch ,  Reinhard Schomaecker ,  Marco Haumann

IPC: C07C4550

CPC classification number: C07C45/50 ,  C07C47/02

Abstract: This invention relates to a process for the catalytic hydroformylation of olefins by reaction of an olefin with hydrogen and carbon monoxide in a liquid, aqueous-organic reaction medium in the presence of a water-soluble hydroformylation catalyst, characterized in that for a substantial period of the hydroformylation reaction, the aqueous-organic medium is present in the form of a microemulsion, which is made up of an oil phase containing the olefin or the olefin and its hydroformylation products, an aqueous phase containing the water-soluble complex catalyst, and a nonionic surfactant.

Abstract translation: 本发明涉及一种在水溶性羰基化催化剂存在下，通过在液体有机反应介质中使烯烃与氢气和一氧化碳反应的烯烃催化加氢甲酰化的方法，其特征在于， 加氢甲酰化反应，水 - 有机介质以微乳液的形式存在，微乳液由含有烯烃或其烯烃及其加氢甲酰化产物的油相，含有水溶性络合物催化剂的水相和 非离子表面活性剂。

公开(公告)号：US06444856B2

公开(公告)日：2002-09-03

申请号：US09867574

申请日：2001-05-31

Applicant: Armin Volker Grenacher ,  Hans-Georg Hein ,  Hans Stepp ,  Hans-Jürgen Fröhlich ,  Willi Schönmann ,  Gerhard Borchert

Inventor： Armin Volker Grenacher ,  Hans-Georg Hein ,  Hans Stepp ,  Hans-Jürgen Fröhlich ,  Willi Schönmann ,  Gerhard Borchert

IPC: C07C4550

CPC classification number: C07C45/50 ,  B01J3/042 ,  B01J4/002 ,  B01J4/007 ,  B01J10/00 ,  B01J19/006 ,  B01J19/26 ,  B01J2219/00051 ,  B01J2219/00162 ,  C07C29/141 ,  C07C47/02 ,  C07C31/125

Abstract: In a process for preparing aldehydes and/or alcohols having from 6 to 30 carbon atoms by hydroformylation of olefins by means of synthesis gas in the presence of a catalyst at from 120° C. to 210° C. and pressures of from 100 to 400 bar, a reaction mixture comprising olefins, synthesis gas and catalyst or catalyst precursor is, according to the present invention, introduced at high velocity into a high-pressure reactor via a nozzle having an adjustable flow cross section.

Abstract translation: 在通过在120℃至210℃的催化剂存在下通过合成气进行烯烃加氢甲酰化制备具有6至30个碳原子的醛和/或醇的方法和压力为100-400 根据本发明，包含烯烃，合成气和催化剂或催化剂前体的反应混合物通过具有可调流动横截面的喷嘴以高速引入高压反应器。

公开(公告)号：US06410799B1

公开(公告)日：2002-06-25

申请号：US09935330

申请日：2001-08-23

Applicant: Frédéric Favre ,  Dominique Commereuc ,  Hélène Olivier-Bourbigou ,  Lucien Saussine

Inventor： Frédéric Favre ,  Dominique Commereuc ,  Hélène Olivier-Bourbigou ,  Lucien Saussine

IPC: C07C4550

CPC classification number: C07C45/50 ,  C07C47/02

Abstract: In a process for hydroformylation of olefinically unsaturated compounds using a catalyst based on cobalt and/or rhodium co-ordinated by at least one ligand selected from the group formed by nitrogen-containing or phosphorus-containing ligands used in a non-aqueous ionic solvent, which catalyst is liquid at a temperature of less than 90° C., in which the aldehydes formed are not or are only slightly soluble and which comprises at least one quaternary ammonium and/or phosphonium cation Q+ and at least one anion A−, the improvement of the invention consists in that in the cobalt and/or rhodium complex, the ligand also carries an ionic function (Q′)+(A′)− where Q and Q′ and/or A and A′ are chemically identical.

Abstract translation: 在使用由选自由非水性离子溶剂中使用的含氮或含磷配位体形成的基团中的至少一种配体所协调的基于钴和/或铑的催化剂的烯属不饱和化合物的加氢甲酰化的方法中， 该催化剂在低于90℃的温度下是液体，其中形成的醛不是或仅仅是微溶的，并且其包含至少一种季铵和/或鏻阳离子Q +和至少一种阴离子A-， 本发明的改进在于在钴和/或铑络合物中，配体还带有离子功能（Q'）+（A'） - 其中Q和Q'和/或A和A'在化学上相同。

公开(公告)号：US06399834B1

公开(公告)日：2002-06-04

申请号：US09831925

申请日：2001-05-15

Applicant: Walter Leitner ,  Sabine Kainz ,  Daniel Koch ,  Giancarlo Francio

Inventor： Walter Leitner ,  Sabine Kainz ,  Daniel Koch ,  Giancarlo Francio

IPC: C07C4550

CPC classification number: C07C45/505 ,  Y02P20/544

Abstract: The present invention relates to methods for producing chiral aldehydes by the enantioselective hydroformylation of prochiral substrates with the aid of a catalyst consisting of a transition metal and a chiral ligand, characterized in that said chiral ligand is a compound of general formula 1 wherein the rings R7-R10 drawn with dotted lines are optional and one or more of rings R1-R6 or R7-R10 are substituted with one or more independently selected substituents of general formula —(CH2)x(CF2)yF(x=0-5; y=1-12) or their branched isomers. In particular, the invention relates to the conducting of the mentioned methods in compressed (liquid or supercritical) carbon dioxide as the reaction medium.

Abstract translation: 本发明涉及通过由过渡金属和手性配体组成的催化剂辅助前手性底物的对映选择性加氢甲酰化来制备手性醛的方法，其特征在于所述手性配体是通式1的化合物，其中R 7〜 用虚线绘制的R10是任选的，并且一个或多个R 1 -R 6或R 7 -R 10的环被一个或多个独立选择的通式 - （CH 2）x（CF 2）y F（x = 0-5; y = 1-12）或其支链异构体。 特别地，本发明涉及在作为反应介质的压缩（液体或超临界）二氧化碳中进行所述方法。

公开(公告)号：US06365782B1

公开(公告)日：2002-04-02

申请号：US09609374

申请日：2000-07-03

Applicant: Kenichi Nakamura ,  Kazuhiro Yamada ,  Takashi Fujii ,  Takashi Motoi

Inventor： Kenichi Nakamura ,  Kazuhiro Yamada ,  Takashi Fujii ,  Takashi Motoi

IPC: C07C4550

CPC classification number: C07C45/50 ,  C07C29/141 ,  C07C29/16 ,  C07C45/80 ,  C07C2603/68 ,  C07C2603/91 ,  C07C47/347 ,  C07C31/278

Abstract: A method of producing tricyclodecane dicarbaldehyde and/or pentacyclopentadecane dicarbaldehyde by the hydroformylation of dicyclopentadiene and/or tricyclopentadiene. The tricyclodecane dicarbaldehyde and/or pentacyclopentadecane dicarbaldehyde in the hydroformylation product liquid are extracted with an extraction solvent comprising a polyhydric alcohol having 2 to 6 carbon atoms. With such extraction, the tricyclodecane dicarbaldehyde and/or pentacyclopentadecane dicarbaldehyde transfer into the extraction solvent while retaining the catalyst components in the hydroformylation solvent. The controlled extraction atmosphere with an oxygen concentration of 1000 ppm or lower prevents the rhodium compound from transferring into the extraction solvent, thereby avoiding the loss of expensive rhodium. The extraction solvent containing tricyclodecane dicarbaldehyde and/or pentacyclopentadecane dicarbaldehyde as such can be directly subjected to catalytic hydrogenation to produce corresponding tricyclodecane dimethanol and/or pentacyclopentadecane dimethanol.

Abstract translation: 通过二环戊二烯和/或三环戊二烯的加氢甲酰化生产三环癸二醛和/或五环十五烷二醛的方法。 加氢甲酰化产物液中的三环癸烷二醛和/或五环十五烷二甲醛用包含具有2至6个碳原子的多元醇的提取溶剂萃取。 通过这样的提取，将三环癸烷二醛和/或五环十五烷二醛转移到萃取溶剂中，同时将催化剂组分保留在加氢甲酰化溶剂中。 氧浓度为1000ppm以下的受控提取气氛防止铑化合物转移到萃取溶剂中，从而避免昂贵的铑的损失。 可以直接对含有三环癸烷二醛和/或五环十五烷二醛的提取溶剂进行催化氢化以产生相应的三环癸烷二甲醇和/或五环十五烷二甲醇。

公开(公告)号：US06307109B1

公开(公告)日：2001-10-23

申请号：US09526039

申请日：2000-03-15

Applicant: Jeffrey Scott Kanel ,  David Robert Bryant ,  Brian Michael Roesch ,  Ailene Gardner Phillips

Inventor： Jeffrey Scott Kanel ,  David Robert Bryant ,  Brian Michael Roesch ,  Ailene Gardner Phillips

IPC: C07C4550

CPC classification number: B01J31/4015 ,  B01J31/1845 ,  B01J31/185 ,  B01J31/24 ,  B01J31/4046 ,  B01J31/4053 ,  B01J2231/32 ,  B01J2231/321 ,  B01J2231/50 ,  B01J2231/641 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/60 ,  B01J2531/80 ,  B01J2531/822 ,  C07B63/00 ,  C07F9/025 ,  Y02P20/582 ,  Y02P20/584

Abstract: This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more products, one or more nonpolar reaction solvents and one or more polar reaction solvents, in which said reaction product fluid exhibits phase behavior depicted by FIG. 1, wherein said process comprises (1) supplying said reaction product fluid from a reaction zone to a separation zone, (2) controlling concentration of said one or more nonpolar reaction solvents and said one or more polar reaction solvents, temperature and pressure in said separation zone sufficient to obtain by phase separation two immiscible liquid phases depicted by regions 2, 4 and 6 of FIG. 1 comprising a polar phase and a nonpolar phase and to prevent or minimize formation of three immiscible liquid phases depicted by region 5 of FIG. 1 and one homogeneous liquid phase depicted by regions 1, 3 and 7 of FIG. 1, and (3) recovering said polar phase from said nonpolar phase or said nonpolar phase from said polar phase.

Abstract translation: 本发明涉及从反应产物流体中分离一种或多种产物的方法，其包括金属 - 有机磷配体配合物催化剂，任选的游离有机磷配体，所述一种或多种产物，一种或多种非极性反应溶剂和一种或多种极性反应溶剂 ，其中所述反应产物流体表现出由图1描绘的相位行为。 1，其中所述方法包括（1）将反应产物流体从反应区供应到分离区，（2）控制所述一种或多种非极性反应溶剂和所述一种或多种极性反应溶剂的浓度，所述的一种或多种极性反应溶剂的温度和压力 分离区足以通过相分离获得图2的区域2,4和6所示的两个不混溶的液相。 1包括极性相和非极性相，并且防止或最小化由图5的区域5描绘的三个不混溶的液相的形成。 1和图1的区域1,3和7所示的一个均匀液相。 1，和（3）从所述极性相从所述非极性相或所述非极性相回收所述极性相。

公开(公告)号：US06307108B1

公开(公告)日：2001-10-23

申请号：US09525651

申请日：2000-03-15

Applicant: John Nicholas Argyropoulos ,  Jeffrey Scott Kanel ,  Michael Leo Tulchinsky ,  David James Miller ,  Donald Lee Morrison ,  Paul Foley ,  David Robert Bryant

Inventor： John Nicholas Argyropoulos ,  Jeffrey Scott Kanel ,  Michael Leo Tulchinsky ,  David James Miller ,  Donald Lee Morrison ,  Paul Foley ,  David Robert Bryant

IPC: C07C4550

CPC classification number: C07C227/08 ,  C07C67/347 ,  C07C67/58 ,  Y02P20/582 ,  C07C69/716 ,  C07C229/08

Abstract: This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more formylester products from a reaction product fluid comprising one or more unreacted unsaturated ester reactants, a metal-organophoshorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, a nonpolar solvent and a polar solvent by phase separation wherein (i) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5 (ii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.

Abstract translation: 本发明涉及一种从包含一种或多种未反应的不饱和酯反应物，金属有机磷配体配合物催化剂的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种甲酰酯产物的方法， 所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，非极性溶剂和极性溶剂通过相分离，其中（i）所述非极性相对于所述有机磷配体的选择性 对于一种或多种产物，通过分配系数比Ef1表示，该分配系数比Ef1是大于约2.5的值（ii）表示非极性相对于一种或多种有机磷配体降解产物的非极性相对于有机磷配体的选择性 通过大于约2的值的分配系数比Ef2。 5，和（iii）非极性相对于有机磷配体相对于一种或多种反应副产物的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。

公开(公告)号：US06175043B1

公开(公告)日：2001-01-16

申请号：US09210232

申请日：1998-12-11

Applicant: Emilio Enrique Bunel

Inventor： Emilio Enrique Bunel

IPC: C07C4550

CPC classification number: B01J31/185 ,  B01J2231/321 ,  B01J2531/0266 ,  B01J2531/80 ,  B01J2531/822 ,  C07C45/50 ,  C07C45/80 ,  C07C51/373 ,  C07C67/313 ,  C07C67/347 ,  C07F9/145 ,  C07C59/147 ,  C07C69/716 ,  C07C47/02

Abstract: The present invention provides an improved hydroformylation process in which the catalyst system is composed of a Group VIII metal and organic phosphite ligand having the structure P(OR)2-OR′O—P(OR)2 or P(OR)3, where R and R′ are organic residues which may be the same or different and where the R or R′ contain at least one C9 to C40 aliphatic group positioned as a tail extending away from the primary ligand structure rendering the ligand lipophilic.

Abstract translation: 本发明提供改进的加氢甲酰化方法，其中催化剂体系由具有结构P（OR）2 -OR'OP（OR）2或P（OR）3）的第Ⅷ族金属和有机亚磷酸酯配体组成，其中R和 R'是可以相同或不同的有机残基，其中R或R'含有至少一个C9至C40脂族基团，其定位为远离主配体结构的尾部，使配体具有亲油性。

公开(公告)号：US06768028B2

公开(公告)日：2004-07-27

申请号：US10150214

申请日：2002-05-17

Applicant: Wilson Tam ,  Kathryn Eileen Schwiebert ,  Joe Douglas Druliner

Inventor： Wilson Tam ,  Kathryn Eileen Schwiebert ,  Joe Douglas Druliner

IPC: C07C4550

CPC classification number: C08G63/6924 ,  B01J31/06 ,  B01J31/1658 ,  B01J31/185 ,  B01J31/28 ,  B01J2231/321 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/828 ,  C07C45/50 ,  C07C67/347 ,  C07C253/30 ,  C07F9/145 ,  C08G63/692 ,  C07C69/716 ,  C07C255/17 ,  C07C47/02

Abstract: A composition and a process for using the composition in hydroformylation of unsaturated organic compounds are disclosed. The composition comprises a Group VIII metal and a phosphite-containing polymer having repeat units derived from (1) a carbonyl compound, a monomer, and phosphochloridite; (2) phosphorus trichloride, a polyhydric alcohol, and an aromatic diol; or (3) combinations of (1) and (2). The process comprises contacting an unsaturated compound, in the presence of the composition disclosed herein, with a fluid comprising hydrogen.

Abstract translation: 公开了一种在不饱和有机化合物的加氢甲酰化中使用该组合物的组合物和方法。 该组合物包含VIII族金属和含有衍生自（1）羰基化合物，单体和磷酸亚氯酸酯的重复单元的含亚磷酸酯聚合物; （2）三氯化磷，多元醇和芳族二醇; 或（3）（1）和（2）的组合。 该方法包括在本文公开的组合物存在下使不饱和化合物与包含氢的流体接触。