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2556 条记录 (耗时 0.038 秒)

    Methods for forming aryl carbon-nitrogen bond using light
    38.
    发明授权
    Methods for forming aryl carbon-nitrogen bond using light 有权

    公开(公告)号：US11104653B2

    公开(公告)日：2021-08-31

    申请号：US16404255

    申请日：2019-05-06

    申请人： Colorado State University Research Foundation

    发明人： Garret Miyake ,  Chern-Hooi Lim ,  Max Kudisch ,  Bin Liu

    IPC分类号： C07D295/073 ,  C07D211/62 ,  C07D211/46 ,  C07C209/68 ,  C07D307/52 ,  C07D213/74 ,  C07D213/38 ,  C07D239/26 ,  C07D235/26 ,  B01J19/12 ,  B01J27/08 ,  B01J35/00 ,  C07D211/06

    摘要： The disclosure relates to a method for forming aryl carbon-nitrogen bonds and to photoreactors useful in these and other light-driven reactions. The method comprises contacting an aryl halide, such as 4-bromobenzotrifluoride, with an amine, such as morpholine, in the presence of a Ni salt catalyst solution and an optional base, thereby forming a reaction mixture; exposing the reaction mixture to light under reaction condition sufficient to produce the aryl carbon-nitrogen bonds, e.g., to give a product such as 4-(4-(trifluoromethyl)phenyl)morpholine. In certain embodiments, the amine may be present in a molar excess to the aryl halide. In certain embodiments, the Ni salt catalyst solution includes a Ni(II) salt and a polar solvent, wherein the Ni(II) salt is dissolved in the polar solvent. In certain embodiments, the reactions conditions include holding the reaction mixture at between about room temperature and about 80° C. for between about 1 hour and about 20 hours such that at least about 50% yield is obtained.