公开(公告)号：US10230369B2

公开(公告)日：2019-03-12

申请号：US14913454

申请日：2014-08-28

Applicant: STC.UNM

Inventor： James Plusquellic ,  James Aarestad

IPC: H05B33/08 ,  H03K19/003 ,  H03K19/21 ,  H03K3/84 ,  H03K23/00

Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

公开(公告)号：US10220008B2

公开(公告)日：2019-03-05

申请号：US14911943

申请日：2014-08-14

Applicant: STC.UNM

Inventor： Jeff Wade Hill

IPC: A61K31/138 ,  A61K9/00 ,  A61K31/27 ,  A61K31/325 ,  A61K45/06 ,  G01N33/50

Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.

公开(公告)号：US20190038735A1

公开(公告)日：2019-02-07

申请号：US16074886

申请日：2017-02-01

Applicant: STC.UNM

Inventor： Pamela Hall ,  Bryce Chackerian ,  David S. Peabody ,  Seth Michael Daly ,  Bradley Owen Elmore ,  Kathleen Triplett

IPC: A61K39/085 ,  A61P31/04 ,  A61P37/04

CPC classification number: A61K39/085 ,  A61K2039/52 ,  A61K2039/5258 ,  A61P31/04 ,  A61P37/04 ,  C12N2795/18123

Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

公开(公告)号：US10192709B2

公开(公告)日：2019-01-29

申请号：US15829278

申请日：2017-12-01

Applicant: STC.UNM

Inventor： Edl Schamiloglu ,  Mikhail I. Fuks

IPC: H01J25/50 ,  H01J23/20 ,  H01J23/02

Abstract: The present invention provides a relativistic magnetron including an anode with an entrant channel, the channel having an input end, an output end and a dimensional discontinuity between the ends. The channel is connected to the magnetron and has an anode defining an interaction space located between the dimensional discontinuity and output end. Also provided is a cathode, located upstream, a spaced distance away from the interaction space towards the input end, the cathode is adapted to send an electron beam into the interaction space where the electron beam forms a virtual cathode in the interaction space.

公开(公告)号：US20190024164A1

公开(公告)日：2019-01-24

申请号：US16069444

申请日：2017-01-11

Applicant: Paul SZAUTER ,  STC.UNM

Inventor： Payman Zarkesh-Ha ,  Jeremy Edwards ,  Paul Szauter

IPC: C12Q1/6874 ,  G01N27/414

Abstract: This disclosure describes, in one aspect, a method of electric-field-assisted nucleotide sequencing. Generally, the method includes performing an ion-sensitive nucleotide sequencing method, applying an electric field across the device while the nucleotide sequencing reactions are being performed so that ions released by the sequencing reactions are directed to contact with the ion-sensitive detector, and detecting at least a portion of the released ions in contact with the ion-sensitive detector.

公开(公告)号：US10183068B2

公开(公告)日：2019-01-22

申请号：US15311298

申请日：2015-05-15

Applicant: STC.UNM

Inventor： Pavan Muttil ,  Denis Wafula ,  Terry Wu ,  Nitesh Kunda ,  Dominique N. Price

IPC: A01N63/00 ,  A61K39/02 ,  A61K9/16 ,  A61K9/00 ,  A61K39/00

Abstract: This disclosure describes, generally, compositions and methods related to thermostable vaccine formulations, their storage, and their use. Generally, the thermostable vaccine formulations can be in the form of a dry powder. The dry powder formulations can increase the length of time that the vaccine remains viable under non-refrigerated, ambient temperature conditions.

公开(公告)号：US20190008882A1

公开(公告)日：2019-01-10

申请号：US16130015

申请日：2018-09-13

Applicant: STC.UNM

Inventor： Vojo P. Deretic ,  Eliseo F. Castillo

IPC: A61K31/704 ,  A61K31/00 ,  A61K31/473 ,  A61K31/38 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/4453 ,  A61K31/4535 ,  A61K31/472 ,  G01N33/569 ,  G01N33/50 ,  G01N33/68 ,  C07K16/28 ,  C07K16/24 ,  A61K45/06 ,  A61K38/17 ,  A61K31/713 ,  A61K31/65 ,  A61K31/57 ,  A61K31/5415 ,  A61K31/506 ,  A61K31/495 ,  A61K31/475 ,  A61K31/277 ,  A61K38/00 ,  A61K9/00

Abstract: In one embodiment, the invention provides a method of treating a subject suffering from a Mycobacterium infection by administering to the subject a therapeutically-effective amount of a degradative autophagy agonist or a secretory autophagy antagonist. In another embodiment, the invention provides a method of treating a subject suffering from one or more diseases selected from the group consisting of a Mycobacterium infection, an inflammatory disorder, an immune disorder, a cancer and a neurodegenerative disorder by administering to the subject a therapeutically-effective amount of a TBK-1 antagonist (e.g. BX795 or amlexanox). Related pharmaceutical compositions, diagnostic and screening assays and kits are also provided.

公开(公告)号：US10172967B2

公开(公告)日：2019-01-08

申请号：US15427355

申请日：2017-02-08

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/00 ,  A61K36/14 ,  A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06

Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

公开(公告)号：US20180370854A1

公开(公告)日：2018-12-27

申请号：US15742852

申请日：2016-07-08

Applicant: STC.UNM

Inventor： Mahmoud Reda Taha ,  Usma Farid Kandil ,  Ala Eddin Douba ,  Mehmet Emiroglu

IPC: C04B26/14 ,  C04B14/02 ,  C01B32/174

Abstract: An electrically and thermally conductive polymer concrete (made of a polymer and aggregate particles without cement) comprising non-functionalized nanoparticles (e.g. non-functionalized multi-walled carbon nanotubes (NF-MWCNTs), non-functionalized carbon nanofibers, non-functionalized nanoalumina) dispersed therein and methods of making same.

公开(公告)号：US20180369430A1

公开(公告)日：2018-12-27

申请号：US16065393

申请日：2016-12-28

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/04

CPC classification number: A61K51/0482 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0453

Abstract: The present invention is directed to novel non-invasive diagnostic took to dispose numerous disease states and/or conditions. The presets invention, represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. The methods described herein are able to diagnose, treat and/or monitor the therapy of numerous diseases and conditions including atherosclerosis, atherothrombosis, cerebral vascular disease, cerebral ischemia, cerebral infarct and meningitis as well as pneumonitis, pericarditis, multiple sclerosis, lupus erythematosus and pancreatitis, among others.