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    Catheter tip
    41.
    发明申请
    Catheter tip 有权
    导管尖

    公开(公告)号：US20030032920A1

    公开(公告)日：2003-02-13

    申请号：US09924380

    申请日：2001-08-07

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Kenneth L. Wantink

    IPC: A61M029/00

    CPC classification number: A61M25/001 ,  A61M25/0069 ,  A61M25/10 ,  A61M2025/1093

    Abstract: A balloon catheter having an improved maneuverability. The catheter includes an elongated catheter shaft with proximal and distal ends, proximal and distal shaft sections, a balloon on the distal catheter shaft section having proximal and distal shaft sections, a guidewire receiving lumen extending along at least a portion of the catheter shaft to the catheter shaft distal end, and a tip member on a distal end of the catheter. A proximal end of the tip member is spaced distally apart from the distal end of the catheter shaft and is in fluid communication therewith. The distal balloon shaft is sealingly secured to the catheter shaft and the tip member.

    Abstract translation: 具有改善的机动性的气囊导管。 导管包括细长的导管轴，其具有近端和远端，近端和远端轴段，远端导管轴部分上具有近端和远端轴段的气囊，沿着导管轴的至少一部分延伸至 导管轴远端，以及在导管的远端上的尖端构件。 尖端构件的近端与导管轴的远端远离地间隔开并与其形成流体连通。 远端球囊轴密封地固定到导管轴和尖端部件上。

    Guidewire having linear change in stiffness
    42.
    发明申请
    Guidewire having linear change in stiffness 有权

    公开(公告)号：US20020156397A1

    公开(公告)日：2002-10-24

    申请号：US09881290

    申请日：2001-06-12

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Wayne E. Cornish ,  John Schreiner ,  James Jacobs ,  Marc M. Jalisi ,  Mark Richardson

    IPC: A61B005/00

    CPC classification number: A61B5/6851 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09175

    Abstract: The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device.

    Medical device chemically modified by plasma polymerization
    43.
    发明申请
    Medical device chemically modified by plasma polymerization 有权
    通过等离子体聚合法化学修饰的医疗器械

    公开(公告)号：US20020146557A1

    公开(公告)日：2002-10-10

    申请号：US09827887

    申请日：2001-04-06

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Charles D. Claude ,  Jeong S. Lee

    IPC: B32B027/06

    CPC classification number: C08J7/123 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0014 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/1034 ,  B05D1/62 ,  Y10S623/926 ,  Y10T428/26 ,  Y10T428/263 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31721 ,  Y10T428/31855

    Abstract: Medical devices, and particularly intracorporeal devices for therapeutic or diagnostic uses, having a component chemically modified by plasma polymerization. The medical device comprises a substrate with a plasma polymerized functionality bonded to a surface of at least a section thereof. The plasma polymerized film on a first component of the medical device allows for bonding an agent or a second component to the first component. In one embodiment, the plasma polymerized film facilitates fusion or adhesive bonding of a first component to a second component formed of a material which is dissimilar to, incompatible with, or otherwise not readily bondable to the substrate material of the first component. In another embodiment, a bioactive agent is bonded to the plasma polymerized film on the component, for presenting or delivering the bioactive agent within a body lumen of the patient.

    Abstract translation: 医疗装置，特别是用于治疗或诊断用途的体内装置，其具有通过等离子体聚合化学改性的组分。 医疗装置包括具有等离子体聚合功能性的基底，其结合至少部分的表面。 医疗装置的第一部件上的等离子体聚合膜允许将试剂或第二组分粘合到第一组分。 在一个实施方案中，等离子体聚合膜促进第一组分与由与第一组分的衬底材料不相容，不相容或不容易粘合的材料形成的第二组分的熔融或粘合。 在另一个实施方案中，生物活性剂与组分上的等离子体聚合膜结合，用于在患者的体腔内呈递或递送生物活性剂。

    Superelastic guiding member
    44.
    发明申请
    Superelastic guiding member 失效

    公开(公告)号：US20020046785A1

    公开(公告)日：2002-04-25

    申请号：US09884432

    申请日：2001-06-18

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Robert M. Abrams ,  Sepehr Fariabi

    IPC: C22C019/03

    CPC classification number: A61M25/09 ,  A61L31/022 ,  A61L31/14 ,  A61L2400/16 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09141 ,  A61M2025/09175 ,  A61M2205/0266 ,  C22C14/00 ,  C22C30/00 ,  C22F1/006

    Abstract: An improved guiding member for use within a body lumen having a unique combination of superelastic characteristics. The superelastic alloy material has a composition consisting of about 30% to about 52% (atomic) titanium, and about 38% to 52% nickel and may have one or more elements selected from the group consisting of iron, cobalt, platinum, palladium, vanadium, copper, zirconium, hafnium and niobium. The alloy material is subjected to thermomechanical processing which includes a final cold working of about 10 to about 75% and then a heat treatment at a temperature between about 450null and about 600null C. and preferably about 475null to about 550null C. Before the heat treatment the cold worked alloy material is preferably subjected to mechanical straightening. The alloy material is preferably subjected to stresses equal to about 5 to about 50% of the room temperature ultimate yield stress of the material during the thermal treatment. The guiding member using such improved material exhibits a stress-induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of over 90 ksi for solid members and over 70 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation. An essentially whip free product is obtained.

    Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device
    45.
    发明申请
    Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device 有权
    用于体内医疗器械的治疗，诊断或亲水涂层

    公开(公告)号：US20020002353A1

    公开(公告)日：2002-01-03

    申请号：US09915413

    申请日：2001-07-25

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Eugene T. Michal ,  Christopher J. Buchko ,  Stephen J. Bigus

    IPC: A61M005/32 ,  B05D003/00 ,  A61F002/06 ,  A61M025/00

    CPC classification number: A61L31/10 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L2420/02 ,  A61L2420/08 ,  A61M2025/0056 ,  C08L89/00

    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.

    Abstract translation: 在体外医疗装置上提供治疗性，诊断性或润滑性的亲水性涂层的方法以及由此制造的涂覆装置，其中涂层是耐用的。 在一个实施方案中，涂层包含聚合的基底涂层和治疗性，诊断性或亲水性顶涂层，其中底涂层具有结合顶部涂层的结合成分，和接合组分，其结合粘合成分并粘附于 设备。 在另一个实施方案中，涂层包含亲水化合物，接枝组分和盐的共混物，其中聚合的接枝组分含有未交联的结构域。 本发明的涂层可以应用于具有聚合物表面的医疗装置，例如聚合物导管，或涂覆有聚合物底漆或无底漆的金属装置或支架。

    High pressure catheter balloon
    46.
    发明申请
    High pressure catheter balloon 有权
    高压导管气囊

    公开(公告)号：US20010027329A1

    公开(公告)日：2001-10-04

    申请号：US09880983

    申请日：2001-06-13

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Murthy V. Simhambhatla ,  Venu Ghanta ,  Timoteo Tomas

    IPC: A61M029/00

    CPC classification number: B29C49/18 ,  A61L29/06 ,  A61L29/14 ,  A61M25/1029 ,  B29C49/6481 ,  B29C2049/0089 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  C08L67/02

    Abstract: A balloon formed of a single layer of polybutylene terephthalate and polytetramethylene ether glycol terephthalate copolymer in a substantially unblended form. The copolymer has a flexural modulus of greater than about 150,000 psi. The presently preferred copolymer is Hytrelnull 8238 by DuPont. The balloon of the invention would be substantially unblended, defined as greater than about 60% by weight to about 100% by weight of the copolymer. The balloon is formed in a series of molds. The balloon of the invention exhibits high rupture pressure and low compliance coupled with good lesion cross and recross ability.

    Abstract translation: 由单层聚对苯二甲酸丁二醇酯和聚四亚甲基醚二醇对苯二甲酸乙二醇酯共聚物形成的气囊，基本上是非混合形式。 共聚物的挠曲模量大于约150,000psi。 目前优选的共聚物是DuPont的Hytrel 8238。 本发明的气囊将基本上未共混，定义为大于约60重量％至约100重量％的共聚物。 气球形成一系列模具。 本发明的气囊显示出高的破裂压力和低顺应性，同时具有良好的病变交叉和回交能力。

    Method of forming a thin walled member by extrusion and medical device produced thereby
    47.
    发明申请
    Method of forming a thin walled member by extrusion and medical device produced thereby 有权
    通过挤出形成薄壁构件的方法和由此制造的医疗装置

    公开(公告)号：US20010004703A1

    公开(公告)日：2001-06-21

    申请号：US09776068

    申请日：2001-02-02

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Stephen J. Tiernan

    IPC: A61M029/02 ,  B29C047/04

    CPC classification number: A61M25/1036 ,  A61M25/0009 ,  B29C47/0023 ,  B29C47/0028 ,  B29C47/0038 ,  B29C47/065 ,  B29C47/26 ,  B29L2023/007 ,  B29L2031/7542

    Abstract: A method of forming a thin-walled polymeric tubular member for an intralumenal device, and the member produced thereby. The thin-walled tubular member extruded using the method of the invention is suitable for use a sleeve for a catheter shaft or balloon. The thin-walled tubular member has a single wall thickness of not greater than about 0.003 inch (0.0076 cm). In the method of the invention, the thin-walled tubular member is formed by co-extruding a thin-walled first polymer layer with a removable second polymer layer, and the two layers are separated by dissolution or physical removal of the second layer, to leave the first layer, with the first polymer layer forming the thin-walled tubular member. Because the method of the invention involves co-extruding a removable second polymer layer along with the thin-walled first polymer layer, conventional tooling dimensions in the extruder may be used.

    Abstract translation: 一种形成用于腔内装置的薄壁聚合物管状构件的方法，以及由此制造的构件。 使用本发明的方法挤出的薄壁管状构件适用于用于导管轴或气囊的套筒。 薄壁管状构件具有不大于约0.003英寸（0.0076cm）的单一壁厚。 在本发明的方法中，通过将薄壁第一聚合物层与可移除的第二聚合物层共挤出而形成薄壁管状构件，并且通过溶解或物理除去第二层来分离两层，至 离开第一层，第一聚合物层形成薄壁管状构件。 因为本发明的方法涉及将可移除的第二聚合物层与薄壁第一聚合物层一起共挤出，所以可以使用挤出机中的常规工具尺寸。

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