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公开(公告)号：US20230207298A1
公开(公告)日：2023-06-29
申请号：US17999637
申请日：2021-05-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Chang Liu , Thomas R. Covey
CPC classification number: H01J49/0454 , H01J49/165
Abstract: An optimal value is calculated for at least one parameter of an ADE device, an OPI, or an ion source device. For each value of a plurality of parameter values for at least one parameter of the ADE device, the OPI, or the ion source device, three steps are performed using a processor. First, the at least one parameter is set to the value. Second, the ADE device, the OPI, the ion source device, and a mass spectrometer are instructed to produce one or more intensity versus time mass peaks for a sample. Third, a feature value is calculated for at least one feature of the one or more intensity versus time mass peaks. A plurality of feature values corresponding to the plurality of parameter values is produced. An optimal value is calculated for the at least one parameter from the plurality of feature values.
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公开(公告)号：US20230207297A1
公开(公告)日：2023-06-29
申请号：US17999617
申请日：2021-05-22
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Wan Ee ANG , Wayne Sng Wei KANG
CPC classification number: H01J49/044 , H01J49/167 , H01J49/025
Abstract: In a sampling interface for mass spectrometry, a method and apparatus are set forth for preventing liquid overflow from a sampling probe into a sample. The apparatus comprises a substrate adapted to retain a droplet of liquid as it forms at an open end of the sampling probe, and a sensor on a surface of the substrate opposite the sample adapted to detect the droplet of liquid and generate a signal for controlling the droplet of liquid before it overflows into the sample.
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公开(公告)号：US11676806B2
公开(公告)日：2023-06-13
申请号：US17260734
申请日：2019-07-17
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold
IPC: H01J49/04
CPC classification number: H01J49/0409 , H01J49/0459
Abstract: Integrated system for delivering sample to a mass spectrometer, which includes a chamber extending from a top to bottom end, an open port probe disposed in the chamber such that an open end of the probe, which is configured for receiving a sample, is positioned in proximity to top end of the chamber. The system can further include a solvent inlet port coupled to said chamber for receiving a solvent and directing said solvent to said probe, and a solvent outlet port for receiving a flow of the solvent from the open port probe and directing the received solvent out of the chamber. The system can also include an adapter for receiving a sample holder having an outlet port, the adapter is releasable and replaceable and couple with chamber to align the outlet port of sample holder with open end of probe for delivering sample to the probe.
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公开(公告)号：US20230178354A1
公开(公告)日：2023-06-08
申请号：US17913225
申请日：2021-03-19
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Aaron T. BOOY
IPC: H01J49/06
CPC classification number: H01J49/063 , H01J49/068
Abstract: In one aspect, an ion guide assembly for use in a mass spectrometry system is disclosed, which comprises a first plurality of multipole rods that are arranged to allow passage of ions therebetween, a second plurality of multipole rods that are arranged to allow passage of ions therebetween, and a board disposed between the first and second plurality of rods, the board comprising an ion lens. The first and second plurality of rods are coupled to the board, and the rods of the first plurality of rods are pairwise aligned with, and coupled to, rods of the second plurality of rods.
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公开(公告)号：US11664210B2
公开(公告)日：2023-05-30
申请号：US16971436
申请日：2019-02-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
CPC classification number: H01J49/107 , H01J49/0031 , H01J49/165
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
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Patent Agency Ranking
公开(公告)号：US11637007B2
公开(公告)日：2023-04-25
申请号：US17458218
申请日：2021-08-26
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Aaron T. Booy
Abstract: In one aspect, a curtain and orifice plate assembly for use in a mass spectrometry system is disclosed, which comprises a curtain plate including a first printed circuit board (PCB) having an aperture configured for receiving ions generated by an ion source of the mass spectrometry system and at least one gas-flow channel, where said first PCB has at least one metal coating disposed on at least a portion thereof. The assembly further includes an orifice plate coupled to the curtain plate, which includes a PCB providing an orifice that is substantially aligned with the aperture of the curtain plate so that the ions entering the assembly via said aperture of the curtain plate can exit the assembly via said orifice of the orifice plate, where the second PCB has at least one metal coating disposed on at least a portion thereof.
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公开(公告)号：US11619623B2
公开(公告)日：2023-04-04
申请号：US16956405
申请日：2018-12-19
Inventor： Aaron Hudson , Takayuki Mizutani , Subhasish Purkayastha , Thomas W. Roscoe
IPC: G01N33/487 , G01N35/00 , G01N35/10 , G01N35/04 , H01J49/26
Abstract: One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.
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公开(公告)号：US20230027201A1
公开(公告)日：2023-01-26
申请号：US17792656
申请日：2021-01-14
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： James HAGER
Abstract: In one aspect, a mass spectrometer is disclosed, which comprises a Fourier Transform (FT) mass analyzer having an input port for receiving ions and an exit port through which the ions exit the FT mass analyzer, a detector disposed downstream of said FT analyzer for detecting ions exiting the FT analyzer, and a multi-segment ion guide having a plurality of segments, said multi-segment ion guide being disposed upstream of said FT mass analyzer and having an input port for receiving ions and an output port through which ions exit the FT mass analyzer. The segments of the ion guide are configured to be independently activated via application of a DC offset voltage thereto so as to adjust a length through which ions passing through the ion guide experience collisional cooling.
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公开(公告)号：US20220359178A1
公开(公告)日：2022-11-10
申请号：US17753036
申请日：2020-08-22
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Yves Le Blanc
Abstract: Before each sample of a series of batch samples is introduced into a liquid sample delivery device, an ion source device receives aqueous mobile phase solution from the liquid sample delivery device and ionizes its compounds, producing an ion beam. A tandem mass spectrometer performs a neutral loss or precursor ion scan on the ion beam to measure intensities of two or more precursor ions corresponding to a known aqueous mobile phase solution compound. Intensity measurements for each of the two or more different precursor ions are compared to previously stored intensities to determine the threshold times at which these measurements indicate orifice contamination. A threshold time is then predicted for a known compound of interest of the batch samples based on the m/z value of the known compound of interest and the m/z value and the threshold time of each of the two or more different precursor ions.
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公开(公告)号：US11424114B2
公开(公告)日：2022-08-23
申请号：US16767760
申请日：2018-11-19
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： John Lawrence Campbell , Scott Hopkins
IPC: H01J49/00 , G06N20/20 , G01N27/62 , G01N27/623
Abstract: A plurality of known compounds with known CCS values is analyzed using a DMS device. The DMS device determines how the intensities of their transmitted ions vary with different separation voltages (SVs) and compensation voltages (CVs). A machine learning algorithm builds a data model from the known m/z value, known CCS value, and measured pairs of CV and SV values that provide optimal transmission through the DMS device for each of the known compounds. An unknown compound with an unknown CCS value is then analyzed. The DMS device determines how the intensity of its ions varies with the same different SVs and CVs. Finally, the machine learning algorithm predicts the CCS value of the unknown compound from the data model, the known m/z of the unknown compound, and the measured pairs of CV and SV values that provide optimal transmission through the DMS device for the unknown compound.
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