公开(公告)号：US06701591B2

公开(公告)日：2004-03-09

申请号：US10251746

申请日：2002-09-20

Applicant: David Collins ,  Charles Keith Curtis ,  Jerry Parker

Inventor： David Collins ,  Charles Keith Curtis ,  Jerry Parker

IPC: D04H146

CPC classification number: A61F13/15707 ,  A61F13/15626 ,  D04H1/495

Abstract: In the present invention, a hydroentangled and three-dimensionally patterned fibrous material is formed from a fibrous matrix to produce a nonwoven fabric of pronounced open area and enhanced physical properties, including abrasive, and particularly wet abrasive, performance. A three-dimensional pattern utilized on the forming surface results in the nonwoven fabric having a diaphanous gauze-like or cheesecloth-like presentation. A method of making a nonwoven material embodying the principles of the present invention contemplates the use of staple length fibers to facilitate economical fabric formation. Formation of the fibrous nonwoven fabric on a three-dimensional, image transfer device by hydroentangling imparts desired physical properties to the fabric such as the controlled placement of the fiber population relative to the desired three-dimensional pattern of the imaging device. This nonwoven fabric may be natural or colored.

Abstract translation: 在本发明中，由纤维基质形成水力缠结和三维图案化的纤维材料，以产生显着的开放面积和增强的物理性质的非织造织物，包括磨料，特别是湿磨性能。 在成形表面上使用的三维图案导致非织造织物具有透明的纱布状或粗棉布样呈现。一种制造体现本发明原理的非织造材料的方法考虑使用短纤维来促进 经济的织物形成。 通过水力缠结在三维图像转印装置上形成纤维无纺织物对织物赋予所需的物理性质，例如相对于成像装置的所需三维图案的纤维群的受控放置。 该无纺布可以是天然的或有色的。

公开(公告)号：US06576488B2

公开(公告)日：2003-06-10

申请号：US09879627

申请日：2001-06-11

Applicant: William David Collins, III ,  Michael R. Krames ,  Godefridus Johannes Verhoeckx ,  Nicolaas Joseph Martin van Leth

Inventor： William David Collins, III ,  Michael R. Krames ,  Godefridus Johannes Verhoeckx ,  Nicolaas Joseph Martin van Leth

IPC: H01L2100

CPC classification number: H01L33/50 ,  C25D13/02 ,  H01L33/405 ,  H01L33/44 ,  H01L2224/48091 ,  H01L2933/0041 ,  H01L2924/00014

Abstract: Presented is a method of conformally coating a light emitting semiconductor structure with a phosphor layer to produce a substantially uniform white light. A light emitting semiconductor structure is coupled to a submount, a first bias voltage is applied to the submount, and a second bias voltage is applied to a solution of charged phosphor particles. The charged phosphor particles deposit on the conductive surfaces of the light emitting semiconductor structure. If the light emitting semiconductor structure includes a nonconductive substrate, the light emitting semiconductor structure is coated with an electroconductive material to induce phosphor deposition. The electrophoretic deposition of the phosphor particles creates a phosphor layer of uniform thickness that produces uniform white light without colored rings.

Abstract translation: 提出了一种使发光半导体结构保形地涂覆有荧光体层以产生基本均匀的白光的方法。 发光半导体结构耦合到基座，将第一偏置电压施加到基座，并且将第二偏压施加到带电荧光体颗粒的溶液。 带电的荧光体颗粒沉积在发光半导体结构的导电表面上。 如果发光半导体结构包括非导电衬底，则用导电材料涂覆发光半导体结构以引起荧光体沉积。 荧光体颗粒的电泳沉积产生均匀厚度的荧光体层，其产生均匀的白色光，而无色环。

公开(公告)号：US06405987B1

公开(公告)日：2002-06-18

申请号：US09368956

申请日：1999-08-05

Applicant: Gregory James Alexander Andrigo ,  Gregory David Collins ,  Hugh D. Downey ,  Richard Allen Lagerweij

Inventor： Gregory James Alexander Andrigo ,  Gregory David Collins ,  Hugh D. Downey ,  Richard Allen Lagerweij

IPC: F16M1300

CPC classification number: B60N2/0705 ,  B60N2/0715 ,  B60N2/0732 ,  B60N2/0887

Abstract: A vehicle seat assembly includes a seat back and a seat bottom and is attached to a vehicle support structure by a mounting assembly. The mounting assembly includes a first track and a second track supported for movement relative to the first track along a first longitudinal axis. The seat bottom is supported on the second track for axial movement with the second track. This allows the seat assembly to be adjusted forwardly or rearwardly by a seat occupant. The seat back can also be moved relative to the second track between an upright position and a recliner position. The seat assembly receives a seat load resulting from the seat occupant sitting in the seat with the seat back in the reclined position and/or from a forward movement of the seat occupant during a deceleration of the vehicle when the seat occupant is belted into the seat. The mounting assembly includes at least one bracket supported on the second track for movement therewith and a reinforcement member that is fixed to the bracket and defines a second longitudinal axis, which is parallel to said first longitudinal axis. The reinforcement member distributes the seat load applied to the bracket along the length of the second track.

Abstract translation: 车辆座椅组件包括座椅靠背和座椅底部，并通过安装组件附接到车辆支撑结构。 安装组件包括第一轨道和第二轨道，第一轨道和第二轨道被支撑成沿着第一纵向轴线相对于第一轨道移动。 座椅底部支撑在第二轨道上，用于与第二轨道轴向移动。 这允许座椅组件由座椅乘客向前或向后调节。 座椅靠背也可以相对于第二轨道在直立位置和斜倚位置之间移动。 座椅组件接收座椅乘员所产生的乘坐座椅，座椅靠背处于倾斜位置和/或座椅乘员在车辆减速期间向前移动时，座椅乘员被带入座椅 。 安装组件包括支撑在第二轨道上的至少一个支架，用于与其一起运动;以及加强构件，该加强构件固定到托架并限定平行于所述第一纵向轴线的第二纵向轴线。 加强构件沿着第二轨道的长度分布施加到支架的座椅负载。

公开(公告)号：US06355267B1

公开(公告)日：2002-03-12

申请号：US08868019

申请日：1997-06-03

Applicant: David Collins

Inventor： David Collins

IPC: A61K9127

CPC classification number: A61K9/1278 ,  A61K9/1277

Abstract: The present invention relates to a method of producing liposomes useful for encapsulating and delivering a wide variety of biologically active materials. The invention provides liposomes and a production method which is simple, feasible and inexpensive for the large-scale commercial manufacturing of liposomes and encapsulated materials. The method involves the formation of a liposome dispersion in the absence of an organic solvent or detergent, one or several cycles of freezing and thawing the liposomes, and dehydration of the liposome dispersion to form a lipid powder. When desired, the lipid powder is hydrated in the presence of the biologically active material whereby the material is encapsulated in reconstituted liposomes. The method can also include combining the liposome dispersion with a bulking agent prior to the dehydration and formation of the lipid powder. The addition of the bulking agent facilitates the handling of the lipid powder as well as its rapid dispersal upon hydration.

Abstract translation: 本发明涉及可用于包封和递送多种生物活性物质的脂质体的制备方法。 本发明提供脂质体和生产方法，其对于脂质体和包封材料的大规模商业制造是简单，可行和便宜的。 该方法包括在不存在有机溶剂或洗涤剂的情况下形成脂质体分散体，使脂质体冷冻融化一个或几个循环，并使脂质体分散体脱水以形成脂质粉末。 当需要时，脂质粉末在生物活性物质的存在下水合，由此将该物质包封在复原的脂质体中。 该方法还可以包括在脱水和形成脂质粉末之前将脂质体分散体与填充剂组合。 填充剂的添加有助于脂质粉末的处理以及其在水合时的快速分散。

公开(公告)号：US06204523B1

公开(公告)日：2001-03-20

申请号：US09187357

申请日：1998-11-06

Applicant: Julian A. Carey ,  William David Collins, III ,  Jason L. Posselt

Inventor： Julian A. Carey ,  William David Collins, III ,  Jason L. Posselt

IPC: H01L3300

CPC classification number: H01L33/62 ,  H01L2924/0002 ,  H01L2924/00

Abstract: An LED component is provided, with light emission in the green-to-near UV wavelength range. The light-emitting semiconductor die is encapsulated with one or more silicone compounds, including a hard outer shell, an interior gel or resilient layer, or both. The silicone material is stable over temperature and humidity ranges, and over exposure to ambient UV radiation. As a consequence, the LED component has an advantageously long lifetime, in which it is free of “yellowing” attenuation which would reduce the green-to-near UV light output.

Abstract translation: 提供了一种LED组件，其发光呈绿色至近紫外波长范围。 发光半导体管芯被一个或多个硅氧烷化合物包封，包括硬的外壳，内部凝胶或弹性层，或两者。 硅胶材料在温度和湿度范围内是稳定的，并且暴露于环境紫外线辐射下。 因此，LED组件具有有利的长寿命，其中它没有“黄化”衰减，这将减少绿色到近紫外光的输出。

公开(公告)号：US6007039A

公开(公告)日：1999-12-28

申请号：US151569

申请日：1998-09-11

Applicant: Nils O. Olsson ,  Gregory David Collins

Inventor： Nils O. Olsson ,  Gregory David Collins

IPC: B60N2/04 ,  B60N2/02 ,  F16C11/04 ,  F16M13/00

CPC classification number: B60N2/0232

Abstract: The present invention relates generally to a fastener used for connecting a first link member to a second link member in a linkage assembly. The second link member includes a pair of aligned apertures and a slot located transversely between the apertures. The first link member includes an aperture at a first end that is designed to be received in the slot located in the second link member. The fastener has a centering post at a distal end and a head portion at a proximal end with a self-tapping portion located between the head portion and the centering post. The aperture in the first link member is aligned with the apertures in the second link member and the fastener is inserted through the apertures until the self-tapping portion contacts the first link member. Thereafter, rotation of the fastener in a first direction taps the self-tapping portion of the fastener through the aperture in the first link member. The fastener is rotated until the first link member is flush against the head portion of the fastener. Thus, the fastener rotatably secures the first link member to the second link member and prevents lateral free play movement between the fastener and the second link member, and between the first link member and the second link member.

Abstract translation: 本发明一般涉及一种用于将第一连杆构件连接到连杆组件中的第二连杆构件的紧固件。 第二连杆构件包括一对对齐的孔和横向位于孔之间的槽。 第一连杆构件包括在第一端处的孔，其被设计成容纳在位于第二连杆构件中的槽中。 紧固件在远端具有定心柱，在近端具有位于头部和定心柱之间的自攻螺纹部分的头部。 第一连杆构件中的孔与第二连杆构件中的孔对准，并且紧固件穿过孔插入，直到自动攻丝部分接触第一连杆构件。 此后，紧固件在第一方向的旋转将紧固件的自攻螺纹部分穿过第一连杆构件中的孔。 紧固件旋转直到第一连杆构件与紧固件的头部齐平。 因此，紧固件将第一连杆构件可旋转地固定到第二连杆构件并且防止紧固件和第二连杆构件之间以及在第一连杆构件和第二连杆构件之间的横向自由移动运动。

公开(公告)号：US5874075A

公开(公告)日：1999-02-23

申请号：US414161

申请日：1995-03-31

Applicant: David Collins ,  Younsik Cha ,  David Brems

Inventor： David Collins ,  Younsik Cha ,  David Brems

IPC: A61K9/127 ,  A61K38/00 ,  A61K38/19 ,  A61K38/22 ,  A61K47/48 ,  A61P7/00 ,  C07K14/52 ,  C07K14/535

CPC classification number: B82Y5/00 ,  A61K38/193 ,  A61K38/196 ,  A61K47/48215 ,  A61K47/48815 ,  A61K9/127 ,  C07K14/52 ,  Y10S930/14 ,  Y10S930/145

Abstract: The invention relates to stable compositions of proteins and related methods wherein a protein capable of transitioning into the molten globular state is contacted with a negatively charged lipid vesicle, thereby stabilizing the protein against thermally-induced aggregation, denaturation, and loss of activity. The protein:phospholipid complex directly stabilizes the secondary and tertiary structure of the protein, and the compositions are useful in high temperature formulations and in novel delivery vehicles.

Abstract translation: 本发明涉及蛋白质的稳定组合物和相关方法，其中能够转变成熔融状态的蛋白质的蛋白质与带负电荷的脂质囊泡接触，从而使蛋白质稳定化，防止热诱导的聚集，变性和活性丧失。 蛋白质：磷脂复合物直接稳定蛋白质的二级和三级结构，并且该组合物可用于高温制剂和新型递送载体。

公开(公告)号：US5700804A

公开(公告)日：1997-12-23

申请号：US381932

申请日：1995-04-11

Applicant: Mark Anthony David Collins ,  Maria Ines Chicarelli-Robinson ,  Justin Stephen Bryans ,  Stephen James Brocchini ,  Christopher John Latham ,  John Richardson Shaw

Inventor： Mark Anthony David Collins ,  Maria Ines Chicarelli-Robinson ,  Justin Stephen Bryans ,  Stephen James Brocchini ,  Christopher John Latham ,  John Richardson Shaw

IPC: A61K31/495 ,  A61P7/02 ,  A61P35/00 ,  C07D241/02 ,  C07D241/08

CPC classification number: C07D241/02

Abstract: Diketopiperazines of the formula: ##STR1## where each of R.sub.1 to R.sub.10, which may be the same or different, is independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by one or more halogen atoms, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, halogen, hydroxy, nitro, phenyl, -cyano, --CH.sub.2 OH, --CH.sub.2 COOH, --CO.sub.2 R.sup.11, --NHCOR.sup.11, --NHSO.sub.2 R.sup.13, --SO.sub.2 R.sup.13, --CON(R.sup.11 R.sup.12), --SOR.sup.13, --SO.sub.2 N(R.sup.11 R.sup.12), --N(R.sup.11 R.sup.12), and --O(CH.sub.2).sub.n N(R.sup.11 R.sup.12), --O(CH.sub.2).sub.n CO.sub.2 R.sup.11, --OCOR.sup.11, --CH.sub.2 OCOR.sup.11, --CH.sub.2 NHCOR.sup.11, --CH.sub.2 NHCOOR.sup.13, --CH.sub.2 SR.sup.11, --CH.sub.2 SCOR.sup.11, --CH.sub.2 S(O).sub.m R.sup.13 wherein m is 1 or 2, --CH.sub.2 NHCO(CH.sub.2).sub.n CO.sub.2 R.sup.11, --N(R.sup.11)COR.sup.12, --NHCOCF.sub.3, --NHCO(CH.sub.2).sub.n CO.sub.2 R.sup.11, --NHCO(CH.sub.2).sub.n OCOR.sup.11 and --NHCO(CH.sub.2).sub.n OR.sup.11 wherein n is 0 or is an integer of from 1 to 6, each of R.sup.11 and R.sup.12 is independently H or C.sub.1 -C.sub.6 alkyl and R.sup.13 is C.sub.1 -C.sub.6 alkyl; or any of R.sub.1 and R.sub.2, R.sub.2 and R.sub.3, R.sub.3 and R.sub.4 and R.sub.4 and R.sub.5, or R.sub.6 and R.sub.7, R.sub.7 and R.sub.8, R.sub.8 and R.sub.9 and R.sub.9 and R.sub.10, form together with the carbon atoms to which they are attached a benzene ring; and pharmaceutically acceptable salts and esters thereof are inhibitors of the plasminogen activator inhibitor.

Abstract translation: PCT No.PCT / GB93 / 01734 Sec。 371日期1995年04月11日 102（e）日期1995年4月11日PCT提交1993年8月16日PCT公布。 第WO94 / 04512号公报 日期：1994年3月3日具有下式的下式的哌嗪基：不同的，独立地选自氢，未被取代或被一个或多个卤素原子取代的C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷硫基 卤素，羟基，硝基，苯基， - 氰基，-CH 2 OH，-CH 2 COOH，-CO 2 R 11，-NHCOR 11，-NHSO 2 R 13，-SO 2 R 13，-CON（R 11 R 12），-SOR 13，-SO 2 N（R 11 R 12）， - N（R 11 R 12） ，和-O（CH 2）n N（R 11 R 12），-O（CH 2）n CO 2 R 11，-OCOR 11，-CH 2 OCOR 11，-CH 2 NHCOR 11，-CH 2 NHCOOR 13，-CH 2 S R 11，-CH 2 SCOR 11，-CH 2 S（O）m R 13，其中m为1或2， -CH2NHCO（CH2）nCO2R11，-N（R11）COR12，-NHCOCF3，-NHCO（CH2）nCO2R11，-NHCO（CH2）nOCOR11和-NHCO（CH2）nOR11，其中n为0或为1至6的整数 R 11和R 12各自独立地为H或C 1 -C 6烷基，R 13为C 1 -C 6烷基; 或R 1和R 2中的任一个，R 2和R 3，R 3和R 4以及R 4和R 5或R 6，R 7，R 7和R 8，R 8和R 9以及R 9和R 10与它们所连接的碳原子一起形成苯环 ; 及其药学上可接受的盐和酯是纤溶酶原激活物抑制剂的抑制剂。

公开(公告)号：US4798376A

公开(公告)日：1989-01-17

申请号：US121122

申请日：1987-11-16

Applicant: Douglas Trumbull ,  David Collins ,  Wayne Smith ,  Robert Spieldiener

Inventor： Douglas Trumbull ,  David Collins ,  Wayne Smith ,  Robert Spieldiener

IPC: A63F9/14 ,  A63G31/16 ,  G09B9/14

CPC classification number: A63G31/16 ,  A63F9/14 ,  G09B9/14

Abstract: An amusement ride is provided, of the type that moves and tilts passengers viewing a motion picture, which is more versatile than prior rides. A plurality of passenger-holding frames is provided, that are all moved in synchronism, each by a separate set of actuators, while the passengers view a stationary screen. The passenger-holding frame is pivoted up and down on a beam which is supported by only two largely vertical actuators, while two pairs of links or arms limit movement of the beam.

Abstract translation: 提供了一种游乐设施，其类型是移动和倾斜乘客观看电影，这比先前的乘车更加通用。 提供了多个乘客保持框架，它们都被同步地移动，每个由一组单独的致动器同时移动，而乘客则观看静止的屏幕。 乘客保持框架在仅由两个主要垂直的致动器支撑的梁上上下枢转，而两对连杆或臂限制梁的移动。

公开(公告)号：US20170181860A1

公开(公告)日：2017-06-29

申请号：US15455422

申请日：2017-03-10

Applicant: CECILE NEROT ,  DIDIER CAPON ,  LUDWIG SEEBAUER ,  ANDERS EKELUND ,  LIEVEN DE WILDE ,  MICHAEL WIRTH ,  DAVID COLLINS ,  LAURENT LAFOSSE ,  DIDIER PONCET

Inventor： CECILE NEROT ,  DIDIER CAPON ,  LUDWIG SEEBAUER ,  ANDERS EKELUND ,  LIEVEN DE WILDE ,  MICHAEL WIRTH ,  DAVID COLLINS ,  LAURENT LAFOSSE ,  DIDIER PONCET

IPC: A61F2/40 ,  A61F2/30

CPC classification number: A61F2/4014 ,  A61F2/30767 ,  A61F2/40 ,  A61F2/4059 ,  A61F2002/30355 ,  A61F2002/30428 ,  A61F2002/30433 ,  A61F2002/3054 ,  A61F2002/30604 ,  A61F2002/30617 ,  A61F2002/30714 ,  A61F2002/30774 ,  A61F2002/30828 ,  A61F2002/30879 ,  A61F2002/4022 ,  A61F2002/4051 ,  A61F2002/4074 ,  A61F2250/0089 ,  A61F2250/0097

Abstract: The invention relates to a modular humeral prosthesis for an inverse shoulder prosthesis, comprising an anatomical shaft (1) and a separable epiphyseal head (2) which may be angularly orientated by rotation about the longitudinal axis (XX) of the anatomical shaft. The anatomical shaft and the epiphyseal head comprise complementary angular indexing means (11, 28) for relative rotational fixation.