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公开(公告)号：US09943684B2
公开(公告)日：2018-04-17
申请号：US14869286
申请日：2015-09-29
Inventor： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
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公开(公告)号：US20150136733A1
公开(公告)日：2015-05-21
申请号：US14540359
申请日：2014-11-13
Applicant: Old Dominion University Research Foundation
Inventor： Helmut BAUMGART , Gon NAMKOONG , Diefeng GU , Tarek ABDEL-FATTAH
CPC classification number: B01D61/427 , B01D67/0062 , B01D67/0072 , B01D69/02 , B01D71/02 , B01D71/022 , B01D71/024 , B01D2313/345 , B01D2325/08 , C23C16/01 , C23C16/403 , F04B19/006
Abstract: Multiple walled nested coaxial nanostructures, methods for making multiple walled nested coaxial nanostructures, and devices incorporating the coaxial nanostructures are disclosed. The coaxial nanostructures include an inner nanostructure, a first outer nanotube disposed around the inner nanostructure, and a first annular channel between the inner nanostructure and the first outer nanotube. The coaxial nanostructures have extremely high aspect ratios, ranging from about 5 to about 1,200, or about 300 to about 1200.
Abstract translation: 公开了多壁嵌套同轴纳米结构，制备多壁嵌套同轴纳米结构的方法以及并入同轴纳米结构的装置。 同轴纳米结构包括内部纳米结构，围绕内部纳米结构设置的第一外部纳米管和内部纳米结构与第一外部纳米管之间的第一环形通道。 同轴纳米结构具有非常高的纵横比，范围为约5至约1200，或约300至约1200。
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公开(公告)号：US20130123469A1
公开(公告)日：2013-05-16
申请号：US13707754
申请日：2012-12-07
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Sandeep Kumar , Patrick G. Hatcher
IPC: C07K1/12
CPC classification number: C07K1/12 , C05F5/004 , C05F5/006 , C08H1/00 , C08H8/00 , C10G1/065 , C12N1/12 , C12P7/62 , C12P7/6436 , C12P7/649 , C12P21/00 , Y02A40/209 , Y02A40/211 , Y02E50/13 , Y02P20/145
Abstract: Methods of fractionating proteins and lipids in algae are provided. The methods can extract peptides and amino acids from algae, can produce components used in food or fertilizer, and can improve algal biomass feed for biofuel production, as non-limiting examples. One embodiment of a method as disclosed herein comprises providing a feed material of algae saturated with water to a reactor, bringing the water saturating the algae to a subcritical temperature within the reactor and separating a reactor effluent into solids and liquid.
Abstract translation: 提供了在藻类中分离蛋白质和脂质的方法。 这些方法可以从藻类中提取肽和氨基酸，可以生产用于食品或肥料的成分，并且可以改善生物燃料生产的藻类生物质饲料作为非限制性实例。 本文公开的方法的一个实施方案包括向反应器提供饱和水的藻类的进料，使藻类饱和的水在反应器内达到亚临界温度，并将反应器流出物分离成固体和液体。
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公开(公告)号：US20250025692A1
公开(公告)日：2025-01-23
申请号：US18713624
申请日：2022-09-23
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Andrei G. PAKHOMOV , Vitalii KIM , Iurii SEMENOV , Emily GUDVANGEN
Abstract: Methods and apparatuses for applying energy to a target tissue or cell are described herein. These methods and apparatuses may use one or more pairs of stimulating electrodes and a dedicated ground electrode to locally apply energy to a target tissue or cell at or adjacent the dedicated ground electrode.
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公开(公告)号：US11351368B2
公开(公告)日：2022-06-07
申请号：US16669419
申请日：2019-10-30
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Shu Xiao , Olga N. Pakhomova , Maura Casciola
Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
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Patent Agency Ranking
公开(公告)号：US11020590B2
公开(公告)日：2021-06-01
申请号：US16104089
申请日：2018-08-16
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Olga N. Pakhomova , Shu Xiao
Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
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公开(公告)号：US10905874B2
公开(公告)日：2021-02-02
申请号：US15922758
申请日：2018-03-15
Inventor： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
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48.发明申请公开(公告)号：US20210026943A1
公开(公告)日：2021-01-28
申请号：US16550450
申请日：2019-08-26
Applicant: Old Dominion University Research Foundation
Inventor： Lauren Nicole Tiller , Catherine Angelini , Sarah Leibner , Jeremiah D. Still
Abstract: The present invention relates to a system and method for authentication of user credentials utilizing a combination of both alphanumeric and graphical password generation and retrieval techniques which includes generating a map with a plurality of symbols populated on the map, wherein the symbols include a plurality of targets and distractors which are associated with alphanumeric characters and wherein a user can utilize the symbols on the map in a particular custom path on the map so as to aid in the generation and future recollection of a selected complex alphanumeric password.
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公开(公告)号：US10792088B2
公开(公告)日：2020-10-06
申请号：US15789727
申请日：2017-10-20
Applicant: Old Dominion University Research Foundation
Inventor： Claudia Muratori , Andrei G. Pakhomov , Olga N. Pakhomova
Abstract: The methods disclosed herein are directed towards improving ablation efficiency associated with applying nanosecond electric pulses (nsEP) to tissue. In particular, applying nsEP to tissue can open pores in the cellular membranes of the tissue. These pores can be kept open longer by cooling the tissue. The combined application of nsEP and the cooling of tissue may have synergistic effects on triggering apoptosis of cells in the tissue. This allows for numerous practical benefits associated with nsEP-based tissue ablation to be realized. For instance, nsEP of lower pulse strength or lower numbers of pulses to be used, which can be provided by smaller pulse generators operating on less power.
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公开(公告)号：US10668278B2
公开(公告)日：2020-06-02
申请号：US15311130
申请日：2015-03-24
Applicant: Old Dominion University Research Foundation
Inventor： Richard Heller , Chen Yeong-Jer
IPC: A61B1/00 , A61N1/32 , A61B18/14 , A61N1/36 , A61N1/05 , A61B1/005 , A61B1/018 , A61B1/04 , A61B1/06 , A61M5/158 , A61B18/00 , A61B18/12
Abstract: Catheter devices can include an elongate housing extending along a major axis, the elongate housing comprising a first end an opening. The catheter devices can also include an electrode assembly disposed in the elongate housing and including deformable electrodes with respective electrode distal ends, where the electrode distal ends each consist of respective member portions and respective tip portions. The electrode assembly is slidably movable within the housing along the major axis to allow the electrode distal end portions to transition between a first retracted position and a second extended position. The catheter device is configured such that an average distance between the tip portions in the second position is configured to be greater than an average distance between the tip portions in the first position the tip portions are positioned substantially in a same plane when the electrode assembly is in the second position.
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