公开(公告)号：US08598120B2

公开(公告)日：2013-12-03

申请号：US13364250

申请日：2012-02-01

Applicant: Christopher J. Soares ,  Michael R. Hanley ,  Diana Y. Lewis ,  David G. Parkes ,  Carolyn M. Jodka ,  Kathryn S. Prickett ,  Soumitra S. Ghosh ,  Christine M. Mack ,  Qing Lin

Inventor： Christopher J. Soares ,  Michael R. Hanley ,  Diana Y. Lewis ,  David G. Parkes ,  Carolyn M. Jodka ,  Kathryn S. Prickett ,  Soumitra S. Ghosh ,  Christine M. Mack ,  Qing Lin

IPC: A61K38/16 ,  A61P3/04 ,  A61P5/22 ,  C07K14/435 ,  C07K19/00

CPC classification number: C07K14/575

Abstract: The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Abstract translation: 本发明涉及在胰岛淀粉样多肽家族中具有肽功能的新化合物，相关核酸，表达构建体，宿主细胞，并且处理化合物的生产。 本发明的化合物包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。

公开(公告)号：US20130087270A1

公开(公告)日：2013-04-11

申请号：US10807546

申请日：2004-03-22

Applicant: Syed Faiyaz Hossainy ,  Yiwen Tang ,  Homayon Askaryar ,  Qing Lin ,  Thierry Glauser

Inventor： Syed Faiyaz Hossainy ,  Yiwen Tang ,  Homayon Askaryar ,  Qing Lin ,  Thierry Glauser

IPC: A61F2/82

CPC classification number: B05D5/00 ,  A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/02

Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.

Abstract translation: 提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。

公开(公告)号：US08114958B2

公开(公告)日：2012-02-14

申请号：US10589054

申请日：2005-02-11

Applicant: Christopher J. Soares ,  Michael R. Hanley ,  Diana Y. Lewis ,  David Geoffrey Parkes ,  Carolyn M. Jodka ,  Kathryn S. Prickett ,  Soumitra S. Ghosh ,  Christine Marie Mack ,  Qing Lin

Inventor： Christopher J. Soares ,  Michael R. Hanley ,  Diana Y. Lewis ,  David Geoffrey Parkes ,  Carolyn M. Jodka ,  Kathryn S. Prickett ,  Soumitra S. Ghosh ,  Christine Marie Mack ,  Qing Lin

IPC: C07K19/00 ,  C07K14/435 ,  A61K38/16 ,  A61P3/04

CPC classification number: C07K14/575

Abstract: The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Abstract translation: 本发明涉及肥胖相关多肽（ORPs），相关核酸，表达构建体，宿主细胞，并且涉及肥胖相关多肽的产生。 本发明的ORP包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。

公开(公告)号：US20100292172A1

公开(公告)日：2010-11-18

申请号：US12785396

申请日：2010-05-21

Applicant: SOUMITRA S. GHOSH ,  JOSUE ALFARO-LOPEZ ,  LAWRENCE J. D'SOUZA ,  ODILE ESTHER LEVY ,  QING LIN ,  CHRISTOPHER J. SOARES

Inventor： SOUMITRA S. GHOSH ,  JOSUE ALFARO-LOPEZ ,  LAWRENCE J. D'SOUZA ,  ODILE ESTHER LEVY ,  QING LIN ,  CHRISTOPHER J. SOARES

IPC: A61K38/17 ,  C07K14/575 ,  C07K14/46 ,  A61K38/22 ,  A61P1/00 ,  A61P9/00

CPC classification number: A61K47/48246 ,  A61K47/545 ,  A61K47/55 ,  A61K47/64

Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract translation: 公开了肽 - 肽酶抑制剂缀合物分子。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

公开(公告)号：US07756689B1

公开(公告)日：2010-07-13

申请号：US11713838

申请日：2007-02-22

Applicant: Ray-Qing Lin ,  Weijia Kuang

Inventor： Ray-Qing Lin ,  Weijia Kuang

IPC: G06F17/10

CPC classification number: G06F17/5009 ,  G06F17/5095 ,  G06F2217/16

Abstract: The present invention's new calculative methodology models the motion of a seagoing vessel in six dimensions, uniquely employing a total velocity potential as the sole parameterization for taking into consideration all linear and nonlinear dynamical effects involved in interaction between the vessel and environmental water. The solid-body rotational motion of the vessel about the vessel's center of mass is determined in three dimensions (roll, pitch, yaw) by calculating the pressure torque and the buoyancy torque. The solid-body translational motion of the vessel's center of mass is determined in three dimensions (heave, surge, sway) by calculating the pressure force and the buoyancy force. The pressure torque and the pressure force are each associated with pressure (e.g., non-hydrostatic pressure) of water on the vessel's surface. The buoyancy torque and the buoyancy force are each associated with the displacement of the vessel with respect to the vessel's equilibrium position in the water.

Abstract translation: 本发明的新的计算方法模拟了六维航海船舶的运动，唯一地采用总速度势能作为唯一参数化，以考虑船舶与环境水相互作用所涉及的所有线性和非线性动力学效应。 通过计算压力转矩和浮力转矩，容器围绕容器质心的固体旋转运动由三维（滚动，俯仰，偏航）确定。 通过计算压力和浮力，确定船体质心的三维实体平移运动（起伏，喘振，摇摆）。 压力扭矩和压力力均与容器表面上的水的压力（例如非静水压力）相关。 浮力扭矩和浮力各自与容器相对于水中的容器平衡位置的位移相关联。

公开(公告)号：US07734449B1

公开(公告)日：2010-06-08

申请号：US11518740

申请日：2006-09-01

Applicant: Ray-Qing Lin ,  Weijia Kuang

Inventor： Ray-Qing Lin ,  Weijia Kuang

IPC: G06F17/10

CPC classification number: G06F17/5018 ,  G06F17/5095 ,  G06F2217/16

Abstract: The hydrodynamics of a seagoing vessel are numerically modeled through the present invention's new calculative methodology, which uniquely combines vessel boundary characteristics and pseudo-spectral environmental characteristics. Solutions are obtained through mutual transformations between the vessel boundary's irregular grid and the environment's regular pseudo-spectral grid. The pressure at the vessel boundary, an important component of the vessel boundary itself, can be determined via either (i) finite element analysis (which has a Cartesian framework) or (ii) the present invention's new vessel normal vector analysis (which has a non-Cartesian framework); the latter approach avoids the singularity problem that generally besets hydrodynamics-related mathematics. Typical inventive practice implements a computer processing unit and succeeds in finding superior solutions in shorter CPU durations.

Abstract translation: 通过本发明的新的计算方法对海船的流体动力学进行数值模拟，其独特地结合了船舶边界特征和伪光谱环境特征。 解决方案是通过船舶边界不规则网格和环境的常规伪光栅网格之间的相互转换获得的。 容器边界上的压力是容器边界本身的一个重要组成部分，可以通过（i）有限元分析（其具有笛卡尔框架）或（ii）本发明的新血管法向量分析（其具有 非笛卡儿框架）; 后一种方法避免了通常困扰流体力学相关数学的奇异性问题。 典型的创造性实践实现了计算机处理单元，并且在更短的CPU持续时间内成功地找到了优异的解决方案。

公开(公告)号：US20100000777A1

公开(公告)日：2010-01-07

申请号：US12198343

申请日：2008-08-26

Applicant: HUI-CHEN ZHAO ,  QING-LIN ZHOU

Inventor： HUI-CHEN ZHAO ,  QING-LIN ZHOU

IPC: H05K1/11

CPC classification number: H05K1/0245 ,  H05K1/0219 ,  H05K1/0222 ,  H05K1/115 ,  H05K2201/09227 ,  H05K2201/09236 ,  H05K2201/09636

Abstract: A printed circuit board includes a first signal via, a second signal via, and a first ground via. A distance between the first ground via and the first signal via is substantially equal to a distance between the first ground via and the second signal via.

Abstract translation: 印刷电路板包括第一信号通孔，第二信号通孔和第一接地通孔。 第一接地通孔和第一信号通孔之间的距离基本上等于第一接地通孔和第二信号通孔之间的距离。

公开(公告)号：US20090186817A1

公开(公告)日：2009-07-23

申请号：US12293389

申请日：2007-03-21

Applicant: Soumitra S. Ghosh ,  Josue Alfaro-Lopez ,  Lawrence J. D'Souza ,  Odile Esther Levy ,  Qing Lin ,  Christopher J. Soares

Inventor： Soumitra S. Ghosh ,  Josue Alfaro-Lopez ,  Lawrence J. D'Souza ,  Odile Esther Levy ,  Qing Lin ,  Christopher J. Soares

IPC: A61K38/22 ,  C07K2/00 ,  C07K14/575

CPC classification number: A61K47/545 ,  A61K47/55 ,  A61K47/64

Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract translation: 公开了肽 - 肽酶抑制剂缀合物分子。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

公开(公告)号：US20080305519A1

公开(公告)日：2008-12-11

申请号：US11709949

申请日：2007-02-23

Applicant: Qing Lin ,  Michael M. Madden

Inventor： Qing Lin ,  Michael M. Madden

IPC: C12P21/06 ,  C07K7/00 ,  C07D235/02

CPC classification number: C07K5/06026 ,  C07K5/0817 ,  C07K5/101 ,  C07K7/06

Abstract: An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing the tag to conjugate to the target protein. The tag may embody at least one structural feature of an ubiquitin C-terminus, and the structural feature may comprise a recognition sequence that is recognizable by an ubiquitin activating enzyme.

Abstract translation: 一种用于蛋白质标记的改进方法，包括提供合成小分子标签，提供待标记的靶蛋白的步骤，提供至少两种用于催化标签和靶蛋白之间的缀合反应的酶，孵育标签，蛋白质和 酶，并使标签与靶蛋白结合。 标签可以体现泛素C-末端的至少一个结构特征，并且结构特征可以包含可被泛素活化酶识别的识别序列。

公开(公告)号：US20050255115A1

公开(公告)日：2005-11-17

申请号：US10478345

申请日：2002-05-23

Applicant: Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Jie Feng ,  Ping Zhou ,  Xiaocong Yu ,  Qing Lin

Inventor： Hualiang Huang ,  Xin Jiang ,  Min Fang ,  Jie Feng ,  Ping Zhou ,  Xiaocong Yu ,  Qing Lin

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  C12N15/13 ,  C12N15/62 ,  C12N15/63 ,  C12P21/08 ,  G01N33/574 ,  C12N5/06

CPC classification number: C07K16/2809 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.

Abstract translation: 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。