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公开(公告)号：US10351608B2
公开(公告)日：2019-07-16
申请号：US14821494
申请日：2015-08-07
Inventor： Bruce L. Riser
IPC: C07K14/47 , A61K38/17 , A61K38/04 , A61K9/00 , A61K35/12 , A61K38/10 , C07K14/475 , A61K35/28 , A61K35/51
Abstract: The present invention provides a method for treating a human patient with a pathology by administering to the subject an effective amount of an agent selected from the group of: native full-length CCN3 proteins; analog CCN3 full-length proteins with native cysteine residues substituted by a replacement amino acid; CCNp native peptide fragments having from about 12 to about 20 amino acids; analog CCNp peptide fragments with native cysteine residues substituted with a replacement amino acid; and combinations thereof.
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公开(公告)号：US10011578B2
公开(公告)日：2018-07-03
申请号：US15671833
申请日：2017-08-08
Inventor： Grace E. Stutzmann , Russell Dahl , Christopher H. Kaiho
IPC: C07D307/52 , C07D307/54 , C07D405/12 , C07D407/12
CPC classification number: C07D307/54 , C07D307/52 , C07D405/12 , C07D407/12
Abstract: Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.
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公开(公告)号：US09827478B1
公开(公告)日：2017-11-28
申请号：US14616522
申请日：2015-02-06
Inventor： Bijan Najafi , James Stanley Wrobel , Ali-Reza Boloori
CPC classification number: A63B69/3608 , A63B71/0619 , A63B2071/0647 , A63B2220/40 , A63B2220/836 , A63B2230/62 , G06F19/3481 , G09B19/0038
Abstract: The present disclosure is directed to a body-worn sensor-based system for evaluating the biomechanics and the motor adaptation characteristics of postural control during a sport activity such as a golf swing. Various embodiments use sensors such as accelerometers, gyroscopes, and magnetometers to measure the three-dimensional motion of ankle and hip joints. In several embodiments, additional sensors attached to other body segments are used to improve the accuracy of the data or detect particular instants during the swing (e.g., top of back swing, instant of the maximum speed of arm, and instant of ball impact). In a golf embodiment, the system combines the measured data in conjunction with a biomechanical model of the human body to: (1) estimate the two-dimensional sway of the golfer's center of mass; (2) quantify and evaluate the golfer's balance via his/her postural compensatory strategy; and (3) provide visual feedback to the golfer for improving dynamic postural control.
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公开(公告)号：US09725429B2
公开(公告)日：2017-08-08
申请号：US14716138
申请日：2015-05-19
Inventor： Grace E. Stutzmann , Russell Dahl , Christopher H. Kaiho
IPC: C07D307/54 , C07D405/12 , C07D307/52 , C07D407/12
CPC classification number: C07D307/54 , C07D307/52 , C07D405/12 , C07D407/12
Abstract: Disclosed herein are methods and compositions comprising compounds of formula (I) capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.
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公开(公告)号：US20170042989A1
公开(公告)日：2017-02-16
申请号：US15234378
申请日：2016-08-11
Applicant: ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE , THE CHINESE UNIVERSITY OF HONG KONG
Inventor： Kwang Poo Chang , Bala Kolli , Dennis K.P. Ng
IPC: A61K39/005 , A61K41/00
CPC classification number: A61K39/005 , A61K41/0019 , A61K47/6901 , A61K2039/521 , A61K2039/523 , Y02A50/41
Abstract: Disclosed herein are methods and compositions for the delivery of polypeptides, including vaccine candidate polypeptides, into mammalian cells comprising the use of photosensitized trypanosomatid organisms. Also disclosed are methods of treatment of trypanosomatid infections comprising administering phthalocyanine compounds or phthalocyanine-treated trypanosomatid microorganisms as vaccines, as well as and polypeptide delivery vectors comprising phthalocyanine-treated trypanosomatid microorganisms.
Abstract translation: 本文公开了用于将多肽（包括疫苗候选多肽）递送到包含使用光敏锥虫病生物体的哺乳动物细胞中的方法和组合物。 还公开了治疗锥虫病感染的方法，包括施用酞菁化合物或酞菁处理的锥虫微生物作为疫苗，以及包含酞菁处理的锥虫病微生物的多肽递送载体。
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Patent Agency Ranking
46.发明授权Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for usher syndrome 有权反义寡核苷酸靶向Ush1c中的隐性剪接位点，作为引发综合征的治疗剂公开(公告)号：US09556434B2
公开(公告)日：2017-01-31
申请号：US14705579
申请日：2015-05-06
Inventor： Michelle L Hastings
IPC: C07H21/04 , C12N15/113 , A61K31/712 , A61K31/7115 , A61K31/7125
CPC classification number: C12N15/113 , A61K31/7115 , A61K31/712 , A61K31/7125 , C12N2310/11 , C12N2320/33
Abstract: The present invention provides a method for treating Usher's syndrome in a human subject including administering to the human subject an oligonucleotide having 8 to 30 linked nucleosides having a nucleobase sequence comprising a complementary region comprising at least 8 contiguous nucleobases complementary to a target region of equal length within exon 3 of an Usher RNA transcript.
Abstract translation: 本发明提供了一种治疗人类受试者的Usher综合征的方法，包括向人类受试者施用具有8至30个连接核苷的寡核苷酸，所述核苷酸具有包含至少8个连续核苷酸序列的互补区的互补区，该互补区与等长的靶区域互补 在Usher RNA转录本的外显子3内。
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47.发明申请METHODS AND KITS FOR DIAGNOSING, PROGNOSING AND MONITORING PARKINSON'S DISEASE 审中-公开诊断，预防和监测帕金森病的方法和工具公开(公告)号：US20160244832A1
公开(公告)日：2016-08-25
申请号：US14870931
申请日：2015-09-30
Inventor： Judith Ann POTASHKIN , Jose Alfredo SANTIAGO
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
Abstract: Increasing evidence indicates that Parkinson's disease (PD) and type 2 diabetes (T2DM) share dysregulated molecular networks. 84 genes shared between PD and T2DM were identified from curated disease-gene databases. Nitric oxide biosynthesis, lipid and carbohydrate metabolism, insulin secretion and inflammation were identified as common dysregulated pathways. A network prioritization approach was implemented to rank genes according to their distance to seed genes and their involvement in common biological pathways. This disclosure reinforces the idea that shared molecular networks between PD and T2DM provide an additional source of biologically meaningful biomarkers.
Abstract translation: 越来越多的证据表明帕金森病（PD）和2型糖尿病（T2DM）共享失调的分子网络。 从策划的疾病 - 基因数据库中鉴定了PD和T2DM之间共有84个基因。 一氧化氮生物合成，脂质和碳水化合物代谢，胰岛素分泌和炎症被鉴定为常见的失调途径。 实施了网络优先化方法，以根据其与种子基因的距离及其参与常规生物学途径的方式对基因进行排序。 本公开强调了PD和T2DM之间的共享分子网络提供了生物学有意义的生物标志物的额外来源的想法。
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公开(公告)号：US20160166193A1
公开(公告)日：2016-06-16
申请号：US14964690
申请日：2015-12-10
Inventor： Fang Lin , Sai V. Yalla
Abstract: The present disclosure provides a system including one or more sensors, a mounting system configured to removeably mount a computing device such that a camera of the computing device is positioned facing an eye of a subject, and a control system. The control system is configured to (a) receive sensor data from the one or more sensors, (b) determine whether the sensor data is indicative of balance instability of the subject, (c) track a position of the eye of the subject to assess vestibular dysfunction, (d) determine whether the camera data is indicative of vestibular dysfunction of the subject, and (e) in response to (i) the sensor data being indicative of balance instability of the subject and/or (ii) the camera data being indicative of vestibular dysfunction of the subject, display an indication of symptoms that are characteristic of a traumatic brain injury or concussion.
Abstract translation: 本公开提供了一种包括一个或多个传感器的系统，配置成可移除地安装计算设备的安装系统，使得计算设备的照相机定位成面向被摄体的眼睛，以及控制系统。 所述控制系统被配置为（a）从所述一个或多个传感器接收传感器数据，（b）确定所述传感器数据是否指示所述对象的平衡不稳定性，（c）跟踪所述对象的眼睛的位置以评估 前庭功能障碍，（d）确定相机数据是否指示受试者的前庭功能障碍，以及（e）响应于（i）传感器数据指示受试者的平衡不稳定性和/或（ii）相机数据 指示受试者的前庭功能障碍，显示出具有创伤性脑损伤或脑震荡特征的症状的指征。
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公开(公告)号：US12285426B2
公开(公告)日：2025-04-29
申请号：US17240969
申请日：2021-04-26
Applicant: The Research Foundation for The State University of new York , Rosalind Franklin University of Medicine and Science , Board of Trustees of Michigan State University
Inventor： Christopher Roy Bishop , Anthony West , Fredric Manfredsson
IPC: A61K31/496 , A61K9/00 , A61K31/05 , A61K31/13 , A61K31/198 , A61K31/4545 , A61K31/495 , A61K31/55 , A61K45/06 , A61P25/16
Abstract: A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.
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公开(公告)号：US11786540B2
公开(公告)日：2023-10-17
申请号：US17371427
申请日：2021-07-09
Applicant: Rosalind Franklin University of Medicine and Science , The United States as Represented by The Department of Veterans Affairs (Washington, D.C.)
Inventor： Raúl J. Gazmuri , Jeejabai Radhakrishnan , Salvatore Aiello
IPC: A61K31/7048
CPC classification number: A61K31/7048
Abstract: A method of performing cardiopulmonary resuscitation on a mammalian subject including the step of delivering an effective amount of a gliflozin solution during cardiac resuscitation through an intravenous or intraosseous route.
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