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    METHOD FOR ELECTROSTATIC COATING OF A MEDICAL DEVICE
    41.
    发明申请
    METHOD FOR ELECTROSTATIC COATING OF A MEDICAL DEVICE 有权
    医疗器械静电涂层方法

    公开(公告)号：US20090285974A1

    公开(公告)日：2009-11-19

    申请号：US12464602

    申请日：2009-05-12

    Applicant: Cameron K. Kerrigan ,  Stephen Pacetti

    Inventor： Cameron K. Kerrigan ,  Stephen Pacetti

    IPC: B05D3/00

    CPC classification number: A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/007

    Abstract: A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.

    Abstract translation: 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。

    METHODS FOR APPLYING AN APPLICATION MATERIAL TO AN IMPLANTABLE DEVICE
    42.
    发明申请
    METHODS FOR APPLYING AN APPLICATION MATERIAL TO AN IMPLANTABLE DEVICE 有权
    将应用材料应用于可植入设备的方法

    公开(公告)号：US20090181160A1

    公开(公告)日：2009-07-16

    申请号：US12331301

    申请日：2008-12-09

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: B05D5/00 ,  A61L33/00

    CPC classification number: B05D3/042 ,  B05D1/002 ,  B05D1/02

    Abstract: Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to a material delivery apparatus. A spray pattern of an application material is produced using the material delivery apparatus. At least a portion of the spray pattern is deflected using a focusing assembly.

    Abstract translation: 公开了将涂层施加到可植入装置的装置和方法。 公开了一种将涂层施加到可植入装置的方法。 该方法包括相对于材料输送装置定位可植入装置。 使用材料输送装置制造涂布材料的喷雾图案。 喷射图案的至少一部分使用聚焦组件偏转。

    METHODS FOR MANUFACTURING COPOLYMERS HAVING 1-METHYL-2-METHOXYETHYL MOIETIES AND USE OF SAME
    44.
    发明申请
    METHODS FOR MANUFACTURING COPOLYMERS HAVING 1-METHYL-2-METHOXYETHYL MOIETIES AND USE OF SAME 有权
    制备具有1-甲基-2-甲氧基乙酸酯的共聚物的方法及其用途

    公开(公告)号：US20080146696A1

    公开(公告)日：2008-06-19

    申请号：US11942707

    申请日：2007-11-19

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: A61L27/34 ,  C08F20/06

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: The copolymers include a hydrophobic monomer and an acryloyl or methacryloyl ester of a propylene glycol monomethyl ether, also referred to as 1-methyl-2-methoxyethyl acrylate (“MMOEA”). The combination of the hydrophobic monomer and the MMOEA monomer advantageously provides desired mechanical strength, biocompatibility, and drug permeability in the copolymers. The copolymers can advantageously be used on medical devices.

    Abstract translation: 共聚物包括疏水单体和丙二醇单甲醚的丙烯酰基或甲基丙烯酰基酯，也称为丙烯酸1-甲基-2-甲氧基乙酯（“MMOEA”）。 疏水单体和MMOEA单体的组合有利地提供共聚物中期望的机械强度，生物相容性和药物渗透性。 共聚物可有利地用于医疗器械上。

    COPOLYMERS HAVING 1-METHYL-2-METHOXYETHYL MOIETIES
    45.
    发明申请
    COPOLYMERS HAVING 1-METHYL-2-METHOXYETHYL MOIETIES 有权
    具有1-甲基-2-甲氧基乙烯醇的共聚物

    公开(公告)号：US20080125560A1

    公开(公告)日：2008-05-29

    申请号：US11942700

    申请日：2007-11-19

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: C08F218/04 ,  A61F2/82

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: The copolymers include a hydrophobic monomer and an acryloyl or methacryloyl ester of a propylene glycol monomethyl ether, also referred to as 1-methyl-2-methoxyethyl acrylate (“MMOEA”). The combination of the hydrophobic monomer and the MMOEA monomer advantageously provides desired mechanical strength, biocompatibility, and drug permeability in the copolymers. The copolymers can advantageously be used on medical devices.

    Abstract translation: 共聚物包括疏水单体和丙二醇单甲醚的丙烯酰基或甲基丙烯酰基酯，也称为丙烯酸1-甲基-2-甲氧基乙酯（“MMOEA”）。 疏水单体和MMOEA单体的组合有利地提供共聚物中期望的机械强度，生物相容性和药物渗透性。 共聚物可有利地用于医疗器械上。

    AMINO ACID MIMETIC COPOLYMERS AND MEDICAL DEVICES COATED WITH THE COPOLYMERS
    46.
    发明申请
    AMINO ACID MIMETIC COPOLYMERS AND MEDICAL DEVICES COATED WITH THE COPOLYMERS 有权
    氨基酸共聚物和与共聚物包衣的医疗装置

    公开(公告)号：US20080125514A1

    公开(公告)日：2008-05-29

    申请号：US11942705

    申请日：2007-11-19

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: A61F2/02

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    Abstract translation: 制造生物相容性聚合物以包括氨基酸模拟单体和一种或多种疏水丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

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