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84 条记录 (耗时 0.125 秒)

    Treatment of inner ear hair cells
    45.
    发明授权
    Treatment of inner ear hair cells 有权
    内耳毛细胞治疗

    公开(公告)号：US06927204B2

    公开(公告)日：2005-08-09

    申请号：US10458039

    申请日：2003-06-09

    申请人： Wei-Qiang Gao

    发明人： Wei-Qiang Gao

    IPC分类号： A61K38/18 ,  A61K38/30 ,  A61K38/00 ,  A61K38/28 ,  A61K39/395 ,  C07K16/00

    CPC分类号： A61K38/1825 ,  A61K38/1841 ,  A61K38/30 ,  Y10S435/81 ,  A61K2300/00

    摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

    摘要翻译： 提供了组合物，方法和装置，用于诱导或增强内耳组织，特别是内耳毛细胞的生长，增殖，再生。 此外，提供了通过施用治疗有效量的IGF-1来预防或治疗患有内耳障碍或病症的哺乳动物，特别是涉及毛细胞损伤，损失或变性的听力损伤的组合物和方法 或FGF-2，或其激动剂，单独或组合使用。

    Treatment of hearing impairments
    50.
    发明授权
    Treatment of hearing impairments 失效
    治疗听力障碍

    公开(公告)号：US06225282B1

    公开(公告)日：2001-05-01

    申请号：US08778357

    申请日：1997-01-02

    申请人： Wei-Qiang Gao

    发明人： Wei-Qiang Gao

    IPC分类号： A61K3800

    CPC分类号： C12N5/062 ,  A61K38/185 ,  C12N2501/13 ,  C12N2503/02

    摘要： Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing impairments involving neuronal damage, loss, or degeneration, preferably of spinal ganglion neurons, by administration of a therapeutically effective amount of a trkB or trkC agonist, particularly a neurotrophin, more preferably NT-4/5. Also provided are improved compositions and methods for treatments requiring administration of a pharmaceutical having an ototoxic side-effect, wherein the improvement includes administering a therapeutically effective amount of a trkB or trkC agonist to treat the ototoxicity.

    摘要翻译： 提供组合物和方法，用于通过施用治疗有效量的trkB或trkC激动剂，特别是神经营养因子来预防或治疗哺乳动物用于涉及神经元损伤，损失或退化，优选脊髓神经节神经元的听力损伤 优选NT-4/5。 还提供了需要施用具有耳毒性副作用的药物的治疗的改进的组合物和方法，其中改进包括施用治疗有效量的trkB或trkC激动剂以治疗耳毒性。