公开(公告)号：US20150125397A1

公开(公告)日：2015-05-07

申请号：US14507719

申请日：2014-10-06

Applicant: ABBVIE INC. ,  UNIVERSITY OF MACHUSETTS

Inventor： Chee-Ho Choi ,  Tariq Ghayur ,  Ann Marshak-Rothstein ,  Krishna Moody

IPC: C07K16/28 ,  A61K45/06 ,  G01N33/564 ,  A61K49/00 ,  G01N33/50 ,  A61K39/395 ,  A61K47/48

CPC classification number: C07K16/2866 ,  A61K39/39533 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K49/0058 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/4283 ,  C07K16/44 ,  C07K2317/31 ,  C07K2317/74 ,  C07K2319/80 ,  C07K2319/85 ,  G01N33/5052 ,  G01N33/564 ,  G01N2333/705 ,  G01N2500/10 ,  G01N2800/52

Abstract: Engineered multivalent and multispecific binding proteins that bind immune cell receptors and/or autoantigens are provided, along with methods of making and uses in the prevention, diagnosis, prognosis and/or treatment of disease.

Abstract translation: 提供结合免疫细胞受体和/或自身抗原的工程化多价和多特异性结合蛋白，以及制备和用于预防，诊断，预后和/或治疗疾病的方法。

公开(公告)号：US20150093387A1

公开(公告)日：2015-04-02

申请号：US14466060

申请日：2014-08-22

Applicant: Abbvie, Inc.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: A61K39/395 ,  C07K16/46

CPC classification number: A61K39/395 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/245 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

公开(公告)号：US08987418B2

公开(公告)日：2015-03-24

申请号：US14323627

申请日：2014-07-03

Applicant: AbbVie Inc.

Inventor： Tariq Ghayur ,  JiJie Gu ,  Maria Harris ,  Carrie Goodreau ,  Sonal Saluja

IPC: C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  C07K16/24 ,  A61K47/48 ,  A61K45/06 ,  C07K14/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K47/6879 ,  C07K16/244 ,  C07K16/245 ,  C07K2317/31 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/545

Abstract: Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 结合IL-1和bgr的工程化多价和多特异性结合蛋白 和/或IL-17，以及在预防，诊断和/或治疗疾病中的制备和用途的方法。

公开(公告)号：US20140335014A1

公开(公告)日：2014-11-13

申请号：US14248223

申请日：2014-04-08

Applicant: AbbVie, Inc.

Inventor： Tariq Ghayur ,  Peter C. Isakson ,  Lisa M. Olson ,  Chengbin Wu ,  Margaret Hugunin ,  Rajesh V. Kamath ,  Carolyn A. Cuff ,  Hamish Allen

IPC: C07K16/46 ,  G01N33/68 ,  A61K45/06 ,  A61K47/48 ,  C07K16/24 ,  A61K39/395

CPC classification number: C07K16/2887 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K2039/505 ,  A61K2039/70 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/247 ,  C07K16/248 ,  C07K16/2866 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

公开(公告)号：US20140294813A1

公开(公告)日：2014-10-02

申请号：US14210703

申请日：2014-03-14

Applicant: AbbVie, Inc.

Inventor： Tariq Ghayur ,  Dominic Ambrosi ,  Arun B. Deora ,  Subramanya Hegde

IPC: C07K16/22

CPC classification number: C07K16/241 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/77

Abstract: Provided are TNF binding proteins and methods of treatment using the same. Also provided are nucleic acids encoding the binding proteins and recombinant expression vectors and host cells for making such binding proteins.

Abstract translation: 提供TNF结合蛋白和使用其的治疗方法。 还提供了编码结合蛋白的核酸和用于产生这种结合蛋白的重组表达载体和宿主细胞。

公开(公告)号：US10040852B2

公开(公告)日：2018-08-07

申请号：US14989532

申请日：2016-01-06

Applicant: AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

Inventor： Mario Mezler ,  Achim Moeller ,  Reinhold Mueller ,  Bernhard K. Mueller ,  Tariq Ghayur ,  Eve H. Barlow ,  Martin Schmidt ,  Axel Meyer ,  Nicole Teusch

IPC: C07K16/28 ,  A61K39/395 ,  C07H21/00 ,  A61K39/00

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

公开(公告)号：US09872861B2

公开(公告)日：2018-01-23

申请号：US15136582

申请日：2016-04-22

Applicant: AbbVie Inc.

Inventor： Steven Elmore ,  Andrew Souers ,  Lichun Wang ,  Tariq Ghayur ,  Stuart J. Perper

IPC: A61K31/497 ,  A61K31/5377 ,  A61K31/496

CPC classification number: A61K31/5377 ,  A61K31/496

Abstract: This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-XL.

公开(公告)号：US09856319B2

公开(公告)日：2018-01-02

申请号：US14141503

申请日：2013-12-27

Applicant: AbbVie, Inc.

Inventor： Tariq Ghayur ,  Jijie Gu

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46

CPC classification number: C07K16/2809 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Engineered monovalent binding proteins that bind to one or more ligands (such as an antigen) via one binding domain are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：US09447184B2

公开(公告)日：2016-09-20

申请号：US14141317

申请日：2013-12-26

Applicant: AbbVie, Inc.

Inventor： Chengbin Wu ,  Dominic J. Ambrosi ,  Chung-ming Hsieh ,  Tariq Ghayur

IPC: C12P21/08 ,  A61K38/00 ,  C07K14/545 ,  C07K16/24 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68 ,  A61K39/395 ,  A61K9/00

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20160175316A1

公开(公告)日：2016-06-23

申请号：US14972983

申请日：2015-12-17

Applicant: AbbVie Inc.

Inventor： Philip Bardwell ,  Tariq Ghayur ,  Jijie Gu ,  Ingela Beatrice Vikstrom ,  Andrew Mark Lew ,  David Matthew Tarlinton ,  Emma Margarele Carrington ,  David Ching Siang Huang

IPC: A61K31/5377 ,  A61K38/13

CPC classification number: A61K31/5377 ,  A61K31/44 ,  A61K31/497 ,  A61K38/13

Abstract: Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.

Abstract translation: 公开了预防或治疗器官，造血干细胞或骨髓移植排斥的方法。