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公开(公告)号：US09452138B2
公开(公告)日：2016-09-27
申请号：US14142651
申请日：2013-12-27
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , John Stankus , James Su , Syed Hossainy , Joshua Takeshi Smith , Shadid Askar
IPC: A61K38/00 , A61K9/14 , A61K9/00 , A61K47/10 , A61K9/08 , C07K16/24 , C07K16/40 , A61K38/21 , A61K39/00
CPC classification number: A61K9/146 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K38/215 , A61K47/10 , A61K2039/505 , C07K16/241 , C07K16/40 , C07K2317/21
Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.
Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。
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42.发明申请Bioabsorbable Stent and Treatment That Elicits Time-Varying Host-Material Response 审中-公开生物可吸收的支架和引起时变主机材料反应的治疗公开(公告)号：US20150313735A1
公开(公告)日：2015-11-05
申请号：US14581993
申请日：2014-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Richard Rapoza , Yunbing Wang , James P. Oberhauser , Syed Hossainy
CPC classification number: A61F2/915 , A61F2/06 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/825 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/412 , C08L67/04
Abstract: Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
Abstract translation: 公开了用生物吸收性支架治疗显示狭窄的患病血管的方法。 植入的支架以增加的直径支撑血管的一段时间，以允许血管愈合。 支架在植入后6个月内失去足以支撑血管的部分的径向强度，丧失机械完整性，然后从该部分脱落。 生物降解支架随着支架退化而导致斑块的性质随时间的变化。 时间依赖性质包括斑块和斑块几何形态参数的腔面积。
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43.发明申请公开(公告)号：US20150305943A1
公开(公告)日：2015-10-29
申请号：US14265343
申请日：2014-04-29
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Syed Hossainy , Paul Consigny , Dariush Davalian , James Su , Michael Ngo , Adrain Gale , Jesus Magana , Mikael Trollsas , Evan Norton , Benjamyn Serna
CPC classification number: A61F2/958 , A61B1/06 , A61F2/915 , A61F11/002 , A61F2002/91575 , A61F2002/91583 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0046 , A61F2250/0048 , A61F2250/005 , A61F2250/0082 , A61M25/10 , A61M29/02 , A61M2025/105 , A61M2025/1059 , A61M2210/0675
Abstract: A polymeric stent can be implanted for treatment of the Eustachian tube. The stent can be designed to have length-dependent radial strength to allow it to stay within the Eustachian tube and to allow normal closing and opening of the Eustachian tube. A balloon can be used to implant the stent, and the balloon can be coated with a therapeutic agent. A coated balloon can also be used to transfer therapeutic agents to the sinus cavity during a balloon sinus dilation procedure.
Abstract translation: 可以植入聚合物支架以治疗咽鼓管。 支架可以被设计成具有长度依赖的径向强度，以允许其停留在咽鼓管内并允许正常的关闭和打开咽鼓管。 可以使用气囊来植入支架，并且可以用治疗剂涂覆气囊。 在气球窦扩张过程中，涂覆的气囊也可以用于将治疗剂转移到窦腔。
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公开(公告)号：US20150265438A1
公开(公告)日：2015-09-24
申请号：US14662171
申请日：2015-03-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Hossainy , Jason Van Sciver , Chad Abunassar
CPC classification number: A61F2/89 , A61F2/844 , A61F2/915 , A61F2/958 , A61F2002/072 , A61F2002/91566 , A61F2210/0004 , A61F2230/0067 , A61F2230/0078 , A61F2250/0018 , A61F2250/0023 , A61F2250/0036 , A61F2250/0039 , A61F2250/0067 , A61L31/041 , C08L67/04
Abstract: A stent or scaffold has a tapered end or ends. The scaffold is made using an additive manufacturing technique such as stereolithography (SLA). The scaffold may take the shape of a frustum, or a scaffold having one or both of its ends flared. The scaffold has varying mechanical properties over its length, such as a varying ring stiffness, porosity or elasticity modulus. In one embodiment the strut and link widths change linearly from the distal to proximal ends.
Abstract translation: 支架或支架具有锥形的端部或端部。 支架采用立体光刻（SLA）等添加剂制造技术制成。 支架可以采用平截头体的形状，或者其支架的一端或两端扩张的支架。 支架在其长度上具有不同的机械性能，例如变化的环刚度，孔隙率或弹性模量。 在一个实施例中，支柱和连杆宽度从远端线向近端改变。
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公开(公告)号：US09095619B2
公开(公告)日：2015-08-04
申请号：US14493197
申请日：2014-09-22
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K31/74 , A61K47/48 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K47/34 , C08L77/12 , A61K31/727
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 还描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。
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Patent Agency Ranking
公开(公告)号：US20150196690A1
公开(公告)日：2015-07-16
申请号：US14599160
申请日：2015-01-16
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
CPC classification number: A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
Abstract: A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, wherein the cytostatic therapeutic agent and the at least one excipient have a weight ratio of about 20:1 to about 1:20, and further wherein the coating provides increased efficiency of therapeutic transfer to a body lumen.
Abstract translation: 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，其中细胞生长抑制治疗剂和至少一种赋形剂的重量比为约20:1至约1:20，并且其中所述涂层提供更高的治疗转移效率 到体腔。
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公开(公告)号：US20140075735A1
公开(公告)日：2014-03-20
申请号：US14085716
申请日：2013-11-20
Applicant: Abbott Cardiovascular Systems Inc,
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zelia Salter
IPC: A61F2/958
CPC classification number: A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
Abstract: A method of crimping a stent is disclosed. The stent includes a minimum crimped diameter such that in the minimum crimped diameter, a pair of stent rings, between which marker support structures reside, do not make contact with the marker support structures. The crimped profile of the stent of the present invention can be as small as the crimped profile of a same stent but without the maker support structures.
Abstract translation: 公开了一种卷曲支架的方法。 支架包括最小卷曲直径，使得在最小卷曲直径处，标记支撑结构所在的一对支架环不与标记支撑结构接触。 本发明的支架的卷曲轮廓可以与同一支架的卷曲轮廓一样小，但没有制造者支撑结构。
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公开(公告)号：US20140067044A1
公开(公告)日：2014-03-06
申请号：US14042496
申请日：2013-09-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasingle , Zella Solter
IPC: A61F2/86
CPC classification number: A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
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公开(公告)号：US20220226133A1
公开(公告)日：2022-07-21
申请号：US17715005
申请日：2022-04-06
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
Abstract: A stent made from a material comprising a polymer is disclosed. The stent has a pre-crimp diameter and a wall thickness such that a ratio of the pre-crimp diameter to the wall thickness is between 30 and 60. The stent has a pattern of interconnected elements. The interconnected elements including a plurality of rings connected by links, wherein each ring includes struts and crowns, and the struts are configured to fold at the crowns when the stent is crimped to the balloon.
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公开(公告)号：US20180325707A1
公开(公告)日：2018-11-15
申请号：US15590817
申请日：2017-05-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Jana Buccola , Joel Harrington , Syed Hossainy , Mary Beth Kossuth , Annie Liu , James Oberhauser , Fuh-Wei Tang
Abstract: A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.
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