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公开(公告)号：US10575948B2
公开(公告)日：2020-03-03
申请号：US15956956
申请日：2018-04-19
Applicant: CARDIOVALVE LTD.
Inventor： Meni Iamberger , Aviram Baum , Ilia Hariton , Yelena Kasimov
Abstract: A frame assembly includes a valve body, a plurality of arms that each extend radially outward from the valve body to a respective arm-tip, and a plurality of ventricular legs that are coupled to the valve body and that extend radially outward from the valve body and toward the plurality of arms. A liner lines the lumen. Prosthetic leaflets are attached to the liner within the lumen. A first sheet of flexible material is attached to the plurality of arms. A second sheet of flexible material is attached to the first sheet and extends radially inwards and downstream, and is attached to the valve body. The first sheet, the second sheet, and the liner define an inflatable pouch therebetween. The apparatus defines a plurality of windows from the lumen into the pouch.
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公开(公告)号：US10531866B2
公开(公告)日：2020-01-14
申请号：US15433547
申请日：2017-02-15
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Tal Reich , Paul Kaye
Abstract: A method is provided, comprising: (1) making a transapical puncture into a left ventricle of the heart; (2) making a transseptal fenestration in the heart; (3) delivering a prosthetic valve via the transapical puncture and implanting the prosthetic valve at a mitral valve of the heart; and (4) subsequently to delivering the prosthetic valve and making the transseptal fenestration, closing the transapical puncture. Other embodiments are also described.
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公开(公告)号：US10463488B2
公开(公告)日：2019-11-05
申请号：US16042129
申请日：2018-07-23
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a method of implanting a prosthetic valve within a native mitral valve may be provided. The method may include delivering the prosthetic valve into a heart chamber. The prosthetic valve may be constrained in a contracted delivery configuration. The prosthetic valve may include an annular valve body with a plurality of ventricular anchors and a plurality of atrial anchors attached thereto. The method may also include unconstraining the plurality of ventricular anchors and the plurality of atrial anchors while maintaining the valve body in the contracted delivery configuration. The method may also include unconstraining the valve body from the contracted delivery configuration while the unconstrained atrial anchors are positioned within an atrium and while the unconstrained ventricular anchors are positioned within a ventricle.
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公开(公告)号：US10426610B2
公开(公告)日：2019-10-01
申请号：US15979686
申请日：2018-05-15
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, an expandable annular valve body may include a plurality of atrial anchoring arms and ventricular anchoring legs extending therefrom. The anchoring arms and anchoring legs may be configured to assume a delivery configuration in which they are radially constrained, such as within a delivery device, and a deployed configuration, in which they may deflect radially outward. The anchoring legs may deflect radially outward by less than 90° when transitioning from the delivery configuration to the deployed configuration. Portions of the anchoring arms may deflect radially outward by at least 90° when transitioning from the delivery configuration to the deployed configuration.
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公开(公告)号：US10357360B2
公开(公告)日：2019-07-23
申请号：US15978494
申请日：2018-05-14
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, an expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may be expandable from a radially contracted state to a radially expanded state. The prosthetic valve may include an expandable outer frame and an inner frame with tissue anchors extending therefrom. The outer and inner frames may be configured and interconnected such that ventricular ends of the inner and outer frames are substantially aligned when the frames are in the radially expanded state and are not substantially aligned when the frames are in the radially contracted state.
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Patent Agency Ranking
公开(公告)号：US20190038404A1
公开(公告)日：2019-02-07
申请号：US15668559
申请日：2017-08-03
Applicant: CARDIOVALVE LTD.
Inventor： Meni Iamberger , Aviram Baum , Boaz Harari , Ilia Hariton
Abstract: A tubular valve body has an upstream end and a downstream end, and has a central longitudinal axis, and defines a lumen along the axis. Prosthetic leaflets are disposed within the lumen, and are configured to facilitate one-way movement of fluid through the lumen in an upstream-to-downstream direction. The valve body has a cellular structure defined by a plurality of joists connected at nodes, the joists and nodes delimiting cells of the cellular structure. The nodes include minor nodes at which 2-4 joists are connected, and major nodes at which 6-8 joists are connected. The cells of the cellular structure comprise a first circumferential row of first-row cells. Each of the first-row cells is connected to each of its circumferentially-adjacent first-row cells at a respective one of the major nodes, and is longitudinally delimited by two of the minor nodes. Other embodiments are described.
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公开(公告)号：US12053380B2
公开(公告)日：2024-08-06
申请号：US17841912
申请日：2022-06-16
Applicant: CARDIOVALVE LTD.
Inventor： Tal Hammer , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.
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公开(公告)号：US11980547B2
公开(公告)日：2024-05-14
申请号：US18135436
申请日：2023-04-17
Applicant: CARDIOVALVE LTD.
Inventor： Boaz Harari , Ilia Hariton
CPC classification number: A61F2/2472 , G01L1/24 , G01N3/04 , A61F2002/7635 , G01B11/02 , G01B11/14 , H04N7/18
Abstract: A method for testing a prosthetic heart valve leaflet is provided. The method includes using a vertical post having a longitudinal axis and a horizontal bar having a bar-axis that lies on a vertical bar-plane. The bar supports the leaflet along the bar-axis such that the leaflet drapes over the bar. A linear actuator movably couples the bar to the post, and actuation of the actuator moves the bar vertically in the bar-plane. A light source emits a beam of light and is oriented to direct the beam through the bar-plane. A gauge measures an elevation of the bar above the beam. A detector is positioned to detect the beam and generates a detection-signal indicative of detection of the beam. Other applications are also described.
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公开(公告)号：US11872130B2
公开(公告)日：2024-01-16
申请号：US16656790
申请日：2019-10-18
Applicant: CARDIOVALVE LTD.
Inventor： Tal Hammer , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
Abstract: A prosthetic heart valve implant is provided including a frame shaped so as to define upstream and downstream openings at upstream and downstream ends of the frame, respectively, when the implant is in an expanded state for implantation at a heart native valve. A sheet is coupled to the frame. When the implant is in the expanded state, the frame is shaped so as to define the following longitudinal portions arranged along a central longitudinal axis of the prosthetic heart valve implant: a substantially cylindrical mid portion having a diameter greater than respective diameters of the upstream and the downstream ends of the frame; an upstream portion, extending upstream and radially inward from the mid portion; and a downstream portion, extending downstream and radially inward from the mid portion. Other embodiments are also described.
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50.发明授权公开(公告)号：US11337803B2
公开(公告)日：2022-05-24
申请号：US16135505
申请日：2018-09-19
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Meni Iamberger , Aviram Baum , Boaz Harari
IPC: A61F2/24
Abstract: A prosthetic heart valve, which may include an expandable annular outer frame having a tubular portion and at least one tissue anchor portion configured to extend from the tubular portion, may be provided. The at least one tissue anchor portion may have a plurality of attachment locations. The prosthetic heart valve may also include an expandable inner frame configured at least partially within the expandable annular outer frame. The expandable inner frame may be connected to the expandable annular outer frame solely at one or more of the plurality of attachment locations of the at least one tissue anchor portion.
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