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公开(公告)号：US5871530A
公开(公告)日：1999-02-16
申请号：US62373
申请日：1998-04-17
申请人： Terrell M. Williams , Peter M. J. Mulier , John G. Keimel , Timothy G. Laske , Gregory A. Boser , Mary M. Morris , Xiaoyi Min
发明人： Terrell M. Williams , Peter M. J. Mulier , John G. Keimel , Timothy G. Laske , Gregory A. Boser , Mary M. Morris , Xiaoyi Min
CPC分类号： A61N1/0565 , A61N1/0563
摘要： A lead and a lead system for dispersion of a cardioversion/defibrillation electrode formed of one or more small diameter defibrillation electrodes in a heart chamber and for attaching a pace/sense electrode in contact with the heart. The small diameter defibrillation electrode or electrodes extend distally from the distal end of the lead body. If multiple electrodes are employed, they are preferably biased to spread apart when unrestrained and have a cross-section size small enough to be inserted into interstices of trabeculae in the ventricular chamber. The distal ends of the defibrillation electrodes may be free of attachment to the lead body or may be attached by a weak bond to the distal portion of the lead.
摘要翻译： 一种用于在心室中由一个或多个小直径除颤电极形成的复律/除颤电极的分散的引线和引导系统，并且用于附接与心脏接触的步调/感测电极。 小直径除颤电极或电极从引线体的远端向远端延伸。 如果使用多个电极，则它们优选地被偏置以在不受限制的情况下展开，并且具有足够小的横截面尺寸以插入心室中的小梁的间隙中。 除颤电极的远端可以没有附着到引线体，或者可以通过弱接合附着到引线的远端部分。
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公开(公告)号：US5843141A
公开(公告)日：1998-12-01
申请号：US846008
申请日：1997-04-25
CPC分类号： H01R13/5224 , A61N1/3752
摘要： An implantable medical device system including an implantable electronic device having multiple electrical connectors and an associated electrical lead also having a corresponding set of electrical connectors which engage with the connectors on the device. The lead has a connector assembly mounted to its proximal end, including the lead's electrical connectors and a mechanical connector. The device has a connector block with a bore extending therethrough sized to receive the connector assembly of the lead. A pulling tool is provided for pulling the lead connector assembly proximally in the bore of said connector block from a first position in which the lead's connector assembly is not fully inserted in the connector block to a second position in which said connector assembly is fully inserted in the connector block, the pulling tool being provided with a mechanical connector which engages with mechanical connector on the lead's connector assembly.
摘要翻译： 一种可植入式医疗装置系统，其包括具有多个电连接器的可植入电子装置和相关联的电引线，该电引线还具有与装置上的连接器接合的对应的一组电连接器。 引线具有安装到其近端的连接器组件，包括引线的电连接器和机械连接器。 该装置具有连接器块，其具有延伸穿过其中的孔，其尺寸适于接纳引线的连接器组件。 提供一种牵引工具，用于将导线连接器组件向近侧拉动在所述连接器块的孔中，从第一位置将导线的连接器组件未完全插入连接器块中的第二位置到第二位置，在第二位置，所述连接器组件完全插入 连接器块，拉动工具设置有机械连接器，其与引线的连接器组件上的机械连接器接合。
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公开(公告)号：US5578068A
公开(公告)日：1996-11-26
申请号：US437460
申请日：1995-05-08
申请人： Timothy G. Laske , Gioi T. Tran
发明人： Timothy G. Laske , Gioi T. Tran
IPC分类号： A61N1/05
CPC分类号： A61N1/0565 , A61N1/056
摘要： A medical electrical lead with an elongated lead body containing an elongated conductor and carrying a tip electrode mounted to and extending the distal tip of the lead body, coupled to the conductor. The distal tip of the lead body includes flange portions extending radially outward from a point immediately adjacent to the electrode and flat portions extending longitudinally and proximally from the electrode. The flange portions and flat portions alternate around the circumference of the lead body tip.
摘要翻译： 一种具有细长引线体的医用电引线，其包含细长的导体，并且携带安装到引线主体的远端并延伸并连接到导体的尖端电极。 引线主体的远端包括从紧邻电极的点径向向外延伸的凸缘部分和从电极纵向和近端延伸的平坦部分。 凸缘部分和平坦部分围绕引线主体末端的圆周交替。
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公开(公告)号：US09468754B2
公开(公告)日：2016-10-18
申请号：US12474645
申请日：2009-05-29
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61B5/042 , A61N1/0534 , A61N1/0541 , A61N1/056
摘要： Selective sensing implantable medical leads include pulsing and sensing portions and pulsing and not sensing portion. Leads and electrodes may be used in defibrillation and as integrated bipolar defibrillation electrodes. An entire electrode can pass charge while a valve metal or valve metal oxide portion of the electrode prevents the entire electrode from sensing, effectively rejecting unwanted signals. Differential conduction pathways, due to the valve metal and/or oxides thereof, cause the portions of the electrodes to conduct differently when used anodically and cathodically. Complex intracardiac electrical gradient can be formed along with a number of virtual electrodes within the tissue. Reentrant loops can thereby be pinned following defibrillation shock.
摘要翻译： 选择性感测可植入医疗引线包括脉冲和感测部分以及脉冲和不感测部分。 引线和电极可用于除颤和作为集成的双极除颤电极。 整个电极可以通过电荷，同时电极的阀金属或阀金属氧化物部分防止整个电极感测，有效地排除不需要的信号。 由于阀门金属和/或其氧化物导致的差动传导路径导致当阳极和阴极使用时，电极的部分不同地传导。 可以与组织内的多个虚拟电极一起形成复杂的心内电梯度。 因此，除颤休克后可以固定可重入环。
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公开(公告)号：US09320871B2
公开(公告)日：2016-04-26
申请号：US13409875
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.
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公开(公告)号：US08475468B2
公开(公告)日：2013-07-02
申请号：US10606909
申请日：2003-06-26
IPC分类号： A61F11/00
CPC分类号： A61B17/3478 , A61B17/3417 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2017/3443 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392
摘要： A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially. The tubular member may be passed through the wall of the heart or the pericardium in its extended configuration and thereafter, the distal-most portion of the tubular member may be moved proximally, causing its diameter enlarge, anchoring the distal end of the catheter or cannula to the pericardium or to the wall of a heart chamber. In these embodiments, the device is preferably provided with a shoulder or flange located proximal to the extendible tubular member, for location on the opposite side of the heart wall or pericardium from the distal end of the catheter or cannula.
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公开(公告)号：US20120245533A1
公开(公告)日：2012-09-27
申请号：US13486523
申请日：2012-06-01
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
IPC分类号： A61M25/14
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body.
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公开(公告)号：US08019437B2
公开(公告)日：2011-09-13
申请号：US10772989
申请日：2004-02-05
申请人： Paul A. Iaizzo , Timothy G. Laske
发明人： Paul A. Iaizzo , Timothy G. Laske
IPC分类号： A61N1/04
CPC分类号： A61N1/057 , A61B5/042 , A61B5/6882 , A61B2018/00273
摘要： A medical electrical lead includes a glue segment to adhere the lead to a treatment site. The glue segment, which may be disposed within a tip electrode of the lead, includes tissue adhesive which may encapsulated within a capsule.
摘要翻译： 医用电引线包括将引线粘附到治疗部位的胶粘部分。 可以设置在引线的尖端电极内的胶合部分包括可以封装在胶囊内的组织粘合剂。
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公开(公告)号：US07184839B2
公开(公告)日：2007-02-27
申请号：US10318518
申请日：2002-12-16
申请人： Willim J. Clemens , Michael L. Freiborg , Michael A. Ruff , Douglas N. Hess , Elisabeth L. Belden , Terrell M. Williams , Brian T. McHenry , Mark B. Bucheger , Timothy G. Laske , Matthew D. Bonner
发明人： Willim J. Clemens , Michael L. Freiborg , Michael A. Ruff , Douglas N. Hess , Elisabeth L. Belden , Terrell M. Williams , Brian T. McHenry , Mark B. Bucheger , Timothy G. Laske , Matthew D. Bonner
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/058
摘要： A lead for delivering electrical signals to and/or receive electrical signals from a human heart that includes a solid inner conductor, and a fixation device having a titanium nitride coated surface and electrically coupled to the inner conductor. A steroid is applied to the titanium nitride surface of the fixation device, and at least one layer of insulation is positioned around the inner conductor. A conductive coil is positioned around and is insulated from the inner conductor, an electrode ring electrically coupled to the conductive coil is positioned around and is electrically isolated from the inner conductor, and an insulating spacer is positioned between and electrically isolates the ring electrode and the fixation device.
摘要翻译： 用于将电信号传递到和/或接收来自包括实心内导体的人心脏的电信号的引线，以及具有氮化钛涂覆表面并电耦合到内导体的固定装置。 将类固醇施加到固定装置的氮化钛表面，并且至少一层绝缘体围绕内部导体定位。 导电线圈定位在内导体周围并与内导体绝缘，电耦合到导电线圈的电极环位于内导体周围并与内导体电隔离，并且绝缘间隔物位于电极之间并电隔离环电极和 固定装置
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公开(公告)号：US07045279B1
公开(公告)日：2006-05-16
申请号：US09419271
申请日：1999-10-15
IPC分类号： C12N5/00
CPC分类号： A01N1/02 , A01N1/0247 , Y10T436/108331
摘要： An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, cardiac implants and other medical devices intended to be used in or on a beating heart. The preparation may also be employed to investigate heart functions, in the presence or absence of such medical devices. In order to allow for visualization of heart structures and devices located within the chambers of the heart, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and the coronary vasculature. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the heart.
摘要翻译： 一种分离的心脏制剂，其中保留了心脏所有四个腔室的基本上正常的泵送活性，允许使用该制剂与电极引线，导管，心脏植入物和旨在用于或在其上使用的其它医疗装置 一个跳动的心脏 在存在或不存在这样的医疗装置的情况下，该制剂也可用于研究心脏功能。 为了允许位于心脏腔室内的心脏结构和装置的可视化，清洁的灌注液（例如具有氧合作用的改良的克雷伯斯缓冲溶液）通过心脏和冠状动脉脉管系统的所有四个腔室循环。 制剂的准备和记录可以与在心脏或心脏上使用的装置的设计，开发和评估结合使用，以及用作调查和教学辅助以帮助医师和学生理解操作 心脏
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