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公开(公告)号：US06653626B2
公开(公告)日：2003-11-25
申请号：US10155364
申请日：2002-05-23
IPC分类号： H01J4926
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
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公开(公告)号：US6106710A
公开(公告)日：2000-08-22
申请号：US393595
申请日：1999-09-10
申请人： Steven M. Fischer , Glen F. Ingle
发明人： Steven M. Fischer , Glen F. Ingle
CPC分类号： G01N30/82 , G01N30/7233
摘要： A fraction collection system for liquid chromatography includes a conduit, which directs a sample eluent from an LC column through a flow splitter to a destructive analytical detector such as a mass spectrometer to analyze sample components, and to a fraction collector. A nondestructive detector such as a photodetector is positioned near the fraction collector to detect arrival of sample components. Optionally, a nondestructive detector such as a photodetector is situated upstream from the splitter, to detect passing sample components. Time intervals between detection of a calibrant or a sample component at any two of the detectors provide for automatable identification of selected sample components at the sample collector.
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43.发明授权
公开(公告)号：US5838003A
公开(公告)日：1998-11-17
申请号：US723201
申请日：1996-09-27
CPC分类号： H01J49/165
摘要： The invention relates to an ionization chamber. More particularly, the invention relates to a mass spectrometer system having an electrospray ionization chamber incorporating an asymmetric electrode.
摘要翻译： 本发明涉及电离室。 更具体地，本发明涉及一种质谱仪系统，其具有结合有不对称电极的电喷雾离子化室。
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44.发明授权Micro concentric tube nebulizer for coupling liquid devices to chemical analysis devices 失效用于将液体装置耦合到化学分析装置的微同心管雾化器
公开(公告)号：US5752663A
公开(公告)日：1998-05-19
申请号：US592040
申请日：1996-01-26
申请人： Steven M. Fischer , Paul C. Goodley
发明人： Steven M. Fischer , Paul C. Goodley
CPC分类号： H01J49/045 , B05B7/066 , G01N21/714
摘要： A method and apparatus for improving pneumatic nebulization of liquids is taught providing for controllable production of droplet size range generated. The improvement is aimed at nebulizers comprised of concentric tubes, the inner transporting analyte liquid, the outer--inert gas. The improvement comprises altering the outer lip of the free end of the inner tube so as to allow laminar flow of the exiting gas. By alteration of the tip, droplets in a controlled size range can be routinely produced with a minimum of operator adjusting.
摘要翻译： 教导了用于改善液体的气动雾化的方法和装置，其提供可控制造产生的液滴尺寸范围。 改进的目的在于由同心管，内部输送分析物液体，外部惰性气体组成的喷雾器。 该改进包括改变内管的自由端的外唇以便允许排出气体的层流。 通过尖端的改变，可以通过最小的操作者调整来常规地产生在受控尺寸范围内的液滴。
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公开(公告)号：US3973440A
公开(公告)日：1976-08-10
申请号：US572603
申请日：1975-04-28
摘要： Small representative samples of catalyst are removed from a fixed bed reactor through a withdrawal conduit and transferred into a sample receiver held at a lower pressure by quickly unsealing the withdrawal conduit and causing a small and sudden gas flow which fluidizes catalyst and lifts it into the withdrawal conduit, through which it falls by the action of gravity.
摘要翻译： 催化剂的小代表性样品通过取出导管从固定床反应器中除去，并通过快速开启取出管道并且引起流动催化剂并将其提升到提取物的小而突然的气体流动而转移到保持在较低压力下的样品接收器中 导管，通过重力的作用下降。
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46.发明授权Peptide derivatization method to increase fragmentation information from MS/MS spectra 有权肽衍生化方法从MS / MS谱增加碎片信息公开(公告)号：US07838303B2
公开(公告)日：2010-11-23
申请号：US11494383
申请日：2006-07-27
IPC分类号： G01N24/00
CPC分类号： G01N33/6821 , G01N33/6848 , Y10T436/24
摘要： A method of facilitating analysis of a peptide in a mass spectrometer comprising derivatizing the C-terminus of the peptide with an amino acid residue via a reaction with a carbodiimide reagent, yielding a derivative peptide, ionizing the derivative peptide with a double charge, and fragmenting the ionized derivative peptide in a mass spectrometry system, wherein binary fragments of the ionized derivative each include a charge, facilitating sequence analysis of the peptide.
摘要翻译： 一种促进质谱分析肽的方法，包括通过与碳二亚胺试剂的反应将肽的C末端与氨基酸残基衍生化，产生衍生肽，以双电荷离子化衍生肽，并将其断裂 质谱系统中的离子化衍生肽，其中电离衍生物的二元片段各自包含电荷，便于肽的序列分析。
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公开(公告)号：US07550259B2
公开(公告)日：2009-06-23
申请号：US11484912
申请日：2006-07-12
IPC分类号： C12Q1/00
CPC分类号： G01N33/6848 , B01L3/5027 , G01N27/447 , G01N30/7233 , G01N33/6851 , H01J49/04
摘要： A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced into a mass spectrometer in the same sequential order so that, within a given time window, the digested proteins introduced into the mass spectrometer are covariant.
摘要翻译： 提供了分析包含多种蛋白质种类的样品的方法。 蛋白质被物种分离，使得多个蛋白质物质以顺序排列出来，然后以从分离过程中出现的顺序消化。 将消化的蛋白质以相同的顺序引入质谱仪，使得在给定的时间窗口内，引入质谱仪的消化蛋白质是共变的。
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公开(公告)号：US07368708B2
公开(公告)日：2008-05-06
申请号：US11399778
申请日：2006-04-07
申请人： Steven M. Fischer
发明人： Steven M. Fischer
CPC分类号： H01T23/00 , H01J49/045 , H01J49/165
摘要： The present invention relates to an apparatus for producing ions from an electrospray assembly. The apparatus comprises an ionization chamber, an electrospray assembly, an isolating electrode, an isolated ionization region within the ionization chamber and optionally, a vacuum interface at a vacuum interface voltage and a vacuum chamber. Sample is introduced into the ionization chamber from an electrospray assembly and transported to an electric field region that is isolated from the electric field created by the electrospray assembly.
摘要翻译： 本发明涉及一种用于从电喷雾组件产生离子的装置。 该装置包括电离室，电喷雾组件，隔离电极，离子化室内的隔离电离区域，以及真空界面电压和真空室中的真空界面。 样品从电喷雾组件引入电离室，并被传送到与由电喷雾组件产生的电场隔离的电场区域。
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公开(公告)号：US07309859B2
公开(公告)日：2007-12-18
申请号：US11290187
申请日：2005-11-30
IPC分类号： H01J49/26
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
摘要翻译： 大气压离子源，例如 用于通过大气压光电离（APPI）产生离子的质谱仪。 它包括蒸发器，用于在蒸发器出口时使蒸汽分子光离子化的光子源，用于将离子输送到例如质谱仪系统的通道和用于将离子引导到通道中的装置。 蒸发器的中心轴线和通道的中心轴线形成大约90度的角度。 本发明中包括一种通过沿着轴的大气压力光离子化产生离子的方法，并将它们引导到与该轴成一定角度的通道中。
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50.发明授权Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis 有权环境压力矩阵辅助激光解吸电离（MALDI）装置及分析方法公开(公告)号：US07193206B2
公开(公告)日：2007-03-20
申请号：US10806907
申请日：2004-03-22
申请人： Jian Bai , Steven M. Fischer , J. Michael Flanagan
发明人： Jian Bai , Steven M. Fischer , J. Michael Flanagan
CPC分类号： H01J49/164
摘要： A mass spectrometer having a matrix-assisted laser desorption ionization (MALDI) source which operates at ambient pressure is disclosed. The apparatus and method are disclosed to analyze at least one sample which contains at least one analyte using matrix-assisted laser desorption ionization (MALDI), which apparatus comprises: The present invention relates to an apparatus and a method for ionizing at least one analyte in a sample for delivery to a mass analysis device, comprising: (a) an ionization enclosure including a passageway configured for delivery of ions to the mass analysis device; (b) means to maintain said ionization enclosure at an ambient pressure of greater than 100 mTorr; (c) a holder configured for maintaining a matrix containing said sample in the ionization enclosure at said ambient pressure; (d) a source of laser energy including means associated with the ionization enclosure for directing the laser energy onto said matrix maintained by the holder at the ambient pressure to desorb and ionize at least a portion of the analyte in the sample, and (e) means for directing at least a portion of the at least one ionized analyte into the passageway. The ambient pressure (AP-MALDI) source is compatible with various mass analyzers, particularly with mass spectrometers and solves many problems associated with conventional MALDI sources operating under vacuum. Atmospheric pressure MALDI is described. The analysis of organic molecules or fragments thereof, particularly biomolecules, e.g., biopolymers and organisms, is described.
摘要翻译： 公开了具有在环境压力下操作的基质辅助激光解吸电离（MALDI）源的质谱仪。 公开了该装置和方法以使用矩阵辅助激光解吸电离（MALDI）分析至少一个含有至少一种分析物的样品，该装置包括：本发明涉及用于将至少一种分析物离子化的装置和方法 用于传送到质量分析装置的样品，包括：（a）电离外壳，其包括经配置以将离子输送到质量分析装置的通道; （b）将所述电离外壳保持在大于100mTorr的环境压力下的装置; （c）构造成用于在所述环境压力下将包含所述样品的基质保持在所述电离外壳中的保持器; （d）激光能量源，其包括与电离外壳相关联的装置，用于将激光能量引导到由保持器在环境压力下维持的所述基体上以解吸并离子化样品中的至少一部分分析物，以及（e） 用于将所述至少一种离子化分析物的至少一部分引导到所述通道中的装置。 环境压力（AP-MALDI）源与各种质量分析仪兼容，特别是与质谱仪兼容，解决了与在真空下运行的常规MALDI源有关的许多问题。 描述了大气压力MALDI。 描述了有机分子或其片段，特别是生物分子，例如生物聚合物和生物体的分析。
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