公开(公告)号：US20090264308A1

公开(公告)日：2009-10-22

申请号：US12301645

申请日：2007-05-22

申请人： Dirk Jan Broer ,  Roel Penterman ,  Ralph Kurt ,  Emiel Peeters ,  Hendrik Roelof Stapert ,  Anke Pierik ,  Aleksey Kolesnychenko ,  Hendrik De Koning

发明人： Dirk Jan Broer ,  Roel Penterman ,  Ralph Kurt ,  Emiel Peeters ,  Hendrik Roelof Stapert ,  Anke Pierik ,  Aleksey Kolesnychenko ,  Hendrik De Koning

IPC分类号： C40B30/04 ,  C12Q1/68 ,  C12M1/34 ,  C40B40/06

CPC分类号： G01K11/16 ,  B01L3/508 ,  B01L2200/147 ,  B01L2300/0636 ,  B01L2300/0663

摘要： This invention provides a biosensor solid or hydrogel substrate comprising one or more temperature indicating agents, each of said one or more temperature indicating agents operating by changing its optical properties and being deposited in and/or at the surface of the biosensor solid or hydrogel substrate as one or more layers and/or spots

摘要翻译： 本发明提供了包含一种或多种温度指示剂的生物传感器固体或水凝胶基质，所述一种或多种温度指示剂中的每一种通过改变其光学性质并沉积在生物传感器固体或水凝胶基质的表面和/ 一个或多个层和/或点

公开(公告)号：US20080255007A1

公开(公告)日：2008-10-16

申请号：US12064670

申请日：2006-08-17

申请人： Dirk Jan Broer ,  Roel Penterman ,  Emiel Peeters ,  Ralph Kurt

发明人： Dirk Jan Broer ,  Roel Penterman ,  Emiel Peeters ,  Ralph Kurt

IPC分类号： C40B60/12 ,  G01N21/01 ,  F15B21/00 ,  G01N33/48

CPC分类号： C09K19/00 ,  B01L3/50273 ,  B01L2200/0647 ,  B01L2300/089 ,  B01L2400/0472 ,  B01L2400/0677 ,  B01L2400/082 ,  C09K19/16 ,  C09K19/22 ,  C09K19/24 ,  F04B19/006 ,  F04B19/24 ,  Y10T137/2082

摘要： The invention relates to a substrate material for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes in the samples, whereby the substrate material is adapted in that way that a flow of the sample or parts thereof in and/or with the substrate material is influenced and/or caused by phase transitions, preferably photoinducable phase transitions, in selected areas of the substrate material.

摘要翻译： 本发明涉及一种用于分析一种或多种流体样品中用于样品中一种或多种分析物的存在，量或同一性的基底材料，由此基底材料以这种方式适应于样品或其部分的流动 /或衬底材料受到衬底材料的选定区域中的相变，优选光致诱导相变的影响和/或引起。

公开(公告)号：US20070081107A1

公开(公告)日：2007-04-12

申请号：US10578061

申请日：2004-11-01

申请人： Hjalmar Huitema ,  Roel Penterman ,  Joost Vogels ,  Stephen Klink ,  Hendrik De Koning ,  Dirk Broer

发明人： Hjalmar Huitema ,  Roel Penterman ,  Joost Vogels ,  Stephen Klink ,  Hendrik De Koning ,  Dirk Broer

IPC分类号： G02F1/136

CPC分类号： G02F1/133377 ,  G02F1/13394 ,  G02F1/1341

摘要： An active matrix display device has an optical layer (7,9,11) comprising a mixture of an electro-optical material and a polymer precursor. An upper surface of the active plate comprises an array of wells (70) such that the upper surface has higher (72) and lower regions, and the optical layer mixture is provided over the active plate. The optical layer is exposed to a stimulus for polymerizing the polymer precursor into a polymer layer constituted by a top surface (9) and by side walls (11), thereby enclosing the electro-optical material between the polymerized material and the active plate to define display pixels. Enclosed bodies of electro-optical material defining display pixels are thus provided over the lower regions. This method uses the processing of the active plate to define wells (70) which provide a height difference which can be used to provide alignment of enclosed display pixels cells. This avoids the need for an alignment mask during the deposition and exposure of the optical layer. In an embodiment of the invention,a layer (74) having affinity to the polymer precursor is provided on the higher regions in a stamping step before exposing the otical layer to the stilus.

摘要翻译： 有源矩阵显示装置具有包含电光材料和聚合物前体的混合物的光学层（7,9,11）。 活性板的上表面包括孔阵列（70），使得上表面具有较高（72）和较低的区域，并且光学层混合物设置在活性板上。 将光学层暴露于用于将聚合物前体聚合成由顶表面（9）和侧壁（11）构成的聚合物层的刺激，从而将聚合材料和活性板之间的电光材料包围以限定 显示像素。 因此，限定显示像素的电光材料的封闭体被提供在下部区域上。 该方法使用活性板的处理来定义提供高度差的孔（70），其可用于提供封闭的显示像素单元的对准。 这避免了在光学层的沉积和曝光期间对对准掩模的需要。 在本发明的一个实施方案中，在将所述纤维层暴露于st状物之前，在冲压步骤中的较高区域上提供对聚合物前体具有亲和力的层（74）。

公开(公告)号：US20060262235A1

公开(公告)日：2006-11-23

申请号：US10569259

申请日：2004-08-17

申请人： Joost Vogels ,  Dirk Broer ,  Roel Penterman ,  Stephen Klink ,  Paulus Duineveld

发明人： Joost Vogels ,  Dirk Broer ,  Roel Penterman ,  Stephen Klink ,  Paulus Duineveld

IPC分类号： G02F1/1335

CPC分类号： G02F1/13718 ,  G02F1/133377 ,  G02F1/1334 ,  G02F1/13473

摘要： The multi-colour liquid crystal display device (1) of the present invention has a plurality of discrete liquid crystal elements (110, 130, 150) that are carried by a surface of a carrier (10). The liquid crystal elements (110, 130, 150), which cover respective parts of the electrode structure (12), each have a polymer layer (114, 134, 154), which encloses a cholesteric liquid crystal material (102, 122, 142) between the polymer layer and the surface of the carrier (10). The discrete liquid crystal elements (110, 130, 150) have been formed by the individual deposition of discrete droplets of a liquid comprising the various cholesteric liquid crystal materials (102, 122, 142) and a polymer precursor followed by exposure of the droplets to a stimulus triggering the polymerization of the polymer precursor.

摘要翻译： 本发明的多色液晶显示装置（1）具有由载体（10）的表面承载的多个离散液晶元件（110,130,150）。 覆盖电极结构（12）的各部分的液晶元件（110,130,150）各自具有聚合物层（114,134,154），其包围胆甾型液晶材料（102,122,142 ）在载体（10）的表面之间。 离散的液晶元件（110,130,150）已经通过单独沉积包含各种胆甾型液晶材料（102,122,142）的液体的离散液滴和聚合物前体，然后将液滴暴露于 引发聚合物前体聚合的刺激。

公开(公告)号：US20060250568A1

公开(公告)日：2006-11-09

申请号：US10567231

申请日：2004-07-05

申请人： Roel Penterman ,  Stephen Klink ,  Joost Vogels ,  Dirk Broer

发明人： Roel Penterman ,  Stephen Klink ,  Joost Vogels ,  Dirk Broer

IPC分类号： C09K19/02

CPC分类号： G02F1/133377 ,  G02F1/1334 ,  G02F1/13394 ,  G02F2202/023

摘要： A polymeric stratified-phase-separated composite (6) which is mechanically robust and simple to manufacture comprises a film of liquid (7), a layer of polymerized material (9) covering the thin film of liquid and supporting members (11) formed of polymerized material and extending from the layer of polymerized material through the thin film of liquid. The supporting members extend onto selected first regions (5b) of a substrate surface (5). The substrate surface has, laid our in accordance with a predetermined pattern, selected first (5b) and second (5a) regions. The first are functionalized for selective accumulation of the liquid. In one embodiment the first and second regions are regions of high and low affinity for polymerizable material respectively. In another, a difference in rate of polymerization is induced by using for example different concentrations of polymerization inhibitor in the first and second regions.

摘要翻译： 机械坚固且易于制造的聚合物分层相分离复合材料（6）包括液体膜（7），覆盖液体薄膜的聚合材料层（9）和由 聚合材料并从聚合材料层延伸通过液体薄膜。 支撑构件延伸到衬底表面（5）的选定的第一区域（5b）上。 基板表面已经按照预定的图案放置我们的第一（5b）和第二（5a）区域。 第一个功能化用于液体的选择性积聚。 在一个实施方案中，第一和第二区域分别是对可聚合材料具有高亲和力和低亲和力的区域。 另一方面，通过在第一和第二区域中使用例如不同浓度的阻聚剂来诱导聚合速率的差异。

公开(公告)号：US06818152B2

公开(公告)日：2004-11-16

申请号：US10203576

申请日：2002-08-09

申请人： Roel Penterman ,  Dirk Jan Broer

发明人： Roel Penterman ,  Dirk Jan Broer

IPC分类号： G02F1333

CPC分类号： C09K19/00 ,  C09K19/38 ,  C09K19/544 ,  G02F1/133377 ,  G02F1/13394 ,  G02F1/1341 ,  G02F1/1347 ,  G02F2001/133368 ,  Y10T428/3162 ,  Y10T428/31794

摘要： A stratified-phase-separated composite comprising a polymeric layer and a liquid layer is obtained by photo-polymerizing a composition comprising a liquid and a photo-polymerizable monomer. In order to obtain well-stratified composites which may contain liquid which does not absorb radiation used to photo-polymerize, the composition and composite comprises a dye which is adapted to absorb radiation used to carry out the photo-polymerization and which selectively accumulates in the polymeric layer.

摘要翻译： 通过光聚合包含液体和可光聚合单体的组合物，获得包含聚合物层和液体层的分层相分离复合物。 为了获得可能含有不吸收用于光聚合的辐射的液体的良好分层的复合材料，组合物和复合材料包括适于吸收用于进行光聚合的辐射的染料，并且其选择性地积聚在 聚合物层。

公开(公告)号：US09874294B2

公开(公告)日：2018-01-23

申请号：US13375789

申请日：2010-06-02

申请人： Remco Christiaan Den Dulk ,  Roel Penterman ,  Menno Willem Jose Prins

发明人： Remco Christiaan Den Dulk ,  Roel Penterman ,  Menno Willem Jose Prins

IPC分类号： F16K99/00 ,  B01L3/00

CPC分类号： F16K99/0001 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2400/0672 ,  B01L2400/0677 ,  F16K99/0044 ,  F16K99/0046 ,  Y10T29/49405

摘要： The invention relates to a valve (2) for controlling a passage of particles from a first region (6) to a second region (7), wherein the valve (2) comprises a valve material (4) having a modifiable degree of penetrability and a valve region (16) comprising the valve material (4), wherein the valve region (16) and the valve material (4) are adapted such that the particles have to penetrate the valve material (4) if the particles pass the valve (2) for being transferred from the first region (6) to the second region (7). The degree of opening of the valve (2) can easily be controlled by modifying the degree of penetrability of the valve material (4), for example, by modifying the temperature of the valve material (4). Moreover, by penetrating the valve material (4) the particles can be separated from other elements like a fluid containing the particles.

公开(公告)号：US09784805B2

公开(公告)日：2017-10-10

申请号：US12665336

申请日：2008-06-16

申请人： Marc Paul Saes ,  Johan Samuel Van Den Brink ,  Filips Van Liere ,  Roel Penterman ,  Ralph Kurt ,  Emiel Peeters ,  Dirk Jan Broer ,  Michel Paul Barbara Van Bruggen ,  Hans Van Zon ,  Miha Fuderer

发明人： Marc Paul Saes ,  Johan Samuel Van Den Brink ,  Filips Van Liere ,  Roel Penterman ,  Ralph Kurt ,  Emiel Peeters ,  Dirk Jan Broer ,  Michel Paul Barbara Van Bruggen ,  Hans Van Zon ,  Miha Fuderer

IPC分类号： G01R33/341 ,  G01R33/3415 ,  G01R33/36

CPC分类号： G01R33/341 ,  G01R33/3415 ,  G01R33/3621 ,  G01R33/3692

摘要： The invention relates to a nuclear magnetic resonance imaging radio frequency-receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analog signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analog-digital converter (118; 226) to convert the analog pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).

公开(公告)号：US20130299015A1

公开(公告)日：2013-11-14

申请号：US13980586

申请日：2012-01-20

申请人： Roel Penterman ,  Johannes Van Eemeren ,  Reinhold Wimberger-Friedl ,  Henrik Van Amerongen

发明人： Roel Penterman ,  Johannes Van Eemeren ,  Reinhold Wimberger-Friedl ,  Henrik Van Amerongen

IPC分类号： F16K51/00

CPC分类号： F16K51/00 ,  B01L3/502738 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/794

摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.

摘要翻译： 本发明涉及用于生物传感器的微型阀，微流体装置，这种装置的使用以及微流体元件。 生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。 该传感器可以用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。

公开(公告)号：US20120190793A1

公开(公告)日：2012-07-26

申请号：US13130939

申请日：2009-11-19

申请人： David Halter ,  Ralph Kurt ,  Emiel Peeters ,  Roel Penterman ,  Dirk Jan Broer ,  Rudolf Mathias Johannes Nicolaas Lamerichs

发明人： David Halter ,  Ralph Kurt ,  Emiel Peeters ,  Roel Penterman ,  Dirk Jan Broer ,  Rudolf Mathias Johannes Nicolaas Lamerichs

IPC分类号： C08G63/91 ,  B29C47/00

CPC分类号： A61L27/54 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/126 ,  A61K51/0491 ,  A61K51/065 ,  A61L27/58 ,  A61L31/148 ,  A61L31/18 ,  A61L2300/44

摘要： The present invention relates to a method for the production of scaffold materials and/or scaffolds for tissue and/or organ engineering, said method comprising the addition of at least one anchoring unit for a labelling agent, to at least one scaffold material and/or to at least one scaffold.

摘要翻译： 本发明涉及生产用于组织和/或器官工程的支架材料和/或支架的方法，所述方法包括向至少一种支架材料和/或至少一种支架材料添加​​至少一个用于标记试剂的锚固单元，和/或 至少一个支架。