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公开(公告)号：US20080171014A1
公开(公告)日：2008-07-17
申请号：US11899819
申请日：2007-09-07
申请人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
发明人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
IPC分类号： A61K38/20 , C07K14/00 , C07K16/00 , C07H21/00 , C12N1/00 , C12N1/21 , C12N5/00 , C12N5/04 , A61P3/00 , A61P31/00 , A61P33/00 , A61P37/00 , A61P19/00 , A61P11/00 , A61P1/00 , C12N1/15 , C12N5/06 , C12N1/16 , C12P21/00 , A61K38/16 , A61K39/395
CPC分类号： A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
摘要翻译： 本发明包括IL-13结合蛋白。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hIL-13活性有害的病症的人类受试者中。
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公开(公告)号：US08825469B1
公开(公告)日：2014-09-02
申请号：US13350897
申请日：2012-01-16
申请人： Sarveshwar Rao Duddu , Franz Josef Och , Eahab E. Ibrahim , Joshua James Estelle , Shankar Kumar
发明人： Sarveshwar Rao Duddu , Franz Josef Och , Eahab E. Ibrahim , Joshua James Estelle , Shankar Kumar
IPC分类号： G10L15/00
CPC分类号： G06F17/2854 , G06F17/2827 , G06F17/2836
摘要： A computer-implemented method includes receiving a document and a request to translate the document to a different language, the document including at least one tag associated with a first portion of text within the document, receiving a manual translation of the document translated by a human translator but not including the at least one tag, generating a plurality of alignments between the document and the manual translation using a statistical alignment model, selecting one of the plurality of alignments based on a likelihood that the first portion of text in the document corresponds to an aligned second portion of text within the manual translation, mapping a location of the tag in the document to a corresponding location within the manual translation based on the selected alignment, and inserting the at least one tag into the manual translation at the corresponding location to obtain a modified manual translation of the document.
摘要翻译： 计算机实现的方法包括接收文档和将文档翻译成不同语言的请求，所述文档包括与文档中的文本的第一部分相关联的至少一个标签，接收由人翻译的文档的手动翻译 翻译器，但不包括所述至少一个标签，使用统计对准模型在所述文档和所述手动翻译之间生成多个对齐，基于所述文档中的第一部分文本对应于的可能性来选择所述多个对齐中的一个 在手动翻译中的对齐的文本的第二部分，基于所选择的对齐，将文档中的标签的位置映射到手动翻译内的对应位置，以及将至少一个标签插入到相应位置处的手动翻译 获取文档的修改后的手动翻译。
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公开(公告)号：US08813690B2
公开(公告)日：2014-08-26
申请号：US12916872
申请日：2010-11-01
申请人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
发明人： Shankar Kumar , Timothy R. Frazier , Donald W. Stanton , Yi Xu , Bruce G. Bunting , Leslie R. Wolf
IPC分类号： F02B75/12
CPC分类号： F02D41/0025 , F02B3/06 , F02B29/0406 , F02D19/061 , F02D19/088 , F02D2041/1433 , F02D2200/0611 , F02M26/05 , F02M26/06 , F02M26/23 , Y02T10/36
摘要： A technique for engine control to account for fuel effects including providing an internal combustion engine and a controller to regulate operation thereof, the engine being operable to combust a fuel to produce an exhaust gas; establishing a plurality of fuel property inputs; establishing a plurality of engine performance inputs; generating engine control information as a function of the fuel property inputs and the engine performance inputs; and accessing the engine control information with the controller to regulate at least one engine operating parameter.
摘要翻译： 一种用于发动机控制以解决燃料效应的技术，包括提供内燃机和控制器以调节其操作，所述发动机可操作以燃烧燃料以产生废气; 建立多个燃料特性输入; 建立多个发动机性能输入; 根据燃料属性输入和发动机性能输入产生发动机控制信息; 以及利用所述控制器访问所述发动机控制信息以调节至少一个发动机操作参数。
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公开(公告)号：US08285536B1
公开(公告)日：2012-10-09
申请号：US12533519
申请日：2009-07-31
IPC分类号： G06F17/28
CPC分类号： G06F17/2809
摘要： Methods, systems, and apparatus, including computer program products, for language translation are disclosed. In one aspect, a method includes accessing a translation hypergraph that represents a plurality of candidate translations, the translation hypergraph including a plurality of paths including nodes connected by edges; calculating first posterior probabilities for each edge in the translation hypergraph; calculating second posterior probabilities for each n-gram represented in the translation hypergraph based on the first posterior probabilities; and performing decoding on the translation hypergraph using the second posterior probabilities to convert a sample text from a first language to a second language.
摘要翻译： 公开了用于语言翻译的方法，系统和装置，包括计算机程序产品。 一方面，一种方法包括访问代表多个候选翻译的翻译超图，所述翻译超图包括包括通过边连接的节点的多个路径; 计算翻译超图中每个边缘的第一个后验概率; 基于第一后验概率计算在翻译超图中表示的每个n-gram的第二后验概率; 以及使用所述第二后验概率在所述翻译超图上执行解码以将来自第一语言的样本文本转换为第二语言。
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公开(公告)号：US20110165066A1
公开(公告)日：2011-07-07
申请号：US13043293
申请日：2011-03-08
申请人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
发明人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
IPC分类号： A61K51/00 , C07K16/24 , A61K39/395 , C12N9/96 , C07H21/00 , A61P43/00 , A61P11/00 , A61P31/00 , A61P29/00 , A61P1/00 , A61P19/00 , A61P37/06 , A61P25/28 , A61P13/12 , A61P9/00 , C12N15/63 , A61P17/02 , C12N5/10 , C12N1/15 , C12N1/11 , C12N1/19 , C12P21/06 , A61K49/00 , A61K38/20
CPC分类号： A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
摘要翻译： 本发明包括IL-13结合蛋白。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hIL-13活性有害的病症的人类受试者中。
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公开(公告)号：US07700739B2
公开(公告)日：2010-04-20
申请号：US11478096
申请日：2006-06-29
申请人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译： 本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。
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公开(公告)号：US20100004920A1
公开(公告)日：2010-01-07
申请号：US12497184
申请日：2009-07-02
CPC分类号： G06F17/2818
摘要： Methods, systems, and apparatus, including computer program products, for language translation are disclosed. In one implementation, a method is provided. The method includes accessing a hypothesis space, where the hypothesis space represents a plurality of candidate translations; performing decoding on the hypothesis space to obtain a translation hypothesis that minimizes an expected error in classification calculated relative to an evidence space; and providing the obtained translation hypothesis for use by a user as a suggested translation in a target translation.
摘要翻译： 公开了用于语言翻译的方法，系统和装置，包括计算机程序产品。 在一个实现中，提供了一种方法。 该方法包括访问假设空间，其中假设空间表示多个候选翻译; 对假设空间进行解码以获得最小化相对于证据空间计算的分类中的期望误差的翻译假设; 并提供所获得的翻译假设供用户使用，作为目标翻译中的建议翻译。
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48.发明授权公开(公告)号：US07442777B2
公开(公告)日：2008-10-28
申请号：US11362452
申请日：2006-02-24
申请人： David S. F. Young , Helen P. Findlay , Susan E. Hahn , Luis A. G. da Cruz , Daad Sayegh , Kristian Rogers , Shankar Kumar , Paul Hinton
发明人： David S. F. Young , Helen P. Findlay , Susan E. Hahn , Luis A. G. da Cruz , Daad Sayegh , Kristian Rogers , Shankar Kumar , Paul Hinton
CPC分类号： G01N33/57492 , A61K47/6849 , A61K47/6851 , A61K51/1027 , A61K51/1045 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/732 , C07K2317/92 , G01N33/56966 , G01N33/5743 , G01N2333/70596
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
摘要翻译： 本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。 本发明还涉及利用本发明的CDMAB的结合测定法。
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49.发明申请AMPHIREGULIN ANTIBODIES AND THEIR USE TO TREAT CANCER AND PSORIASIS 审中-公开AMPHIREGULIN抗体及其用于治疗癌症和PSORIASIS的用途公开(公告)号：US20080226632A1
公开(公告)日：2008-09-18
申请号：US11752825
申请日：2007-05-23
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： G01N33/574 , A61K47/6855 , A61K2039/505 , C07K16/22 , C07K2317/73 , G01N2333/485
摘要： The present invention is directed to anti-AR antibodies, preferably humanized monoclonal antibodies having the amino acid sequences disclosed herein. The present invention includes a pharmaceutical composition comprising such antibodies. The present invention includes a method of inhibiting cancer cell growth comprising administering such antibodies into a subject. The present invention also provides a method of treating cancer or psoriasis in a subject in need of such a treatment by administering such antibodies to said subject in a pharmaceutically effective amount.
摘要翻译： 本发明涉及抗AR抗体，优选具有本文公开的氨基酸序列的人源化单克隆抗体。 本发明包括含有这种抗体的药物组合物。 本发明包括抑制癌细胞生长的方法，其包括向受试者施用此类抗体。 本发明还提供了通过以药学上有效量向所述受试者施用这种抗体来治疗需要这种治疗的受试者中的癌症或牛皮癣的方法。
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50.发明授权Methods for synthesis of semiconductor nanocrystals and thermoelectric compositions 失效半导体纳米晶体和热电组合物的合成方法公开(公告)号：US07255846B2
公开(公告)日：2007-08-14
申请号：US11120725
申请日：2005-05-03
申请人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
发明人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
CPC分类号： C01B19/007 , B82Y30/00 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/30 , C01P2004/38 , C01P2004/62 , C01P2004/64 , C04B35/547 , C04B35/632 , C04B35/63488 , C04B35/645 , C04B2235/32 , C04B2235/3201 , C04B2235/3281 , C04B2235/3291 , C04B2235/3293 , C04B2235/3296 , C04B2235/50 , C04B2235/5454 , C04B2235/549 , C04B2235/77 , C04B2235/781 , C04B2235/96 , C04B2235/9607 , H01M4/581 , Y10S977/773 , Y10S977/775 , Y10S977/813 , Y10S977/814
摘要： The present invention provides methods for synthesis of IV–VI nanostructures, and thermoelectric compositions formed of such structures. In one aspect, the method includes forming a solution of a Group IV reagent, a Group VI reagent and a surfactant. A reducing agent can be added to the solution, and the resultant solution can be maintained at an elevated temperature, e.g., in a range of about 20° C. to about 360° C., for a duration sufficient for generating nanoparticles as binary alloys of the IV–VI elements.
摘要翻译： 本发明提供了合成IV-VI纳米结构的方法和由这种结构形成的热电组合物。 一方面，该方法包括形成IV族试剂，VI族试剂和表面活性剂的溶液。 可以向溶液中加入还原剂，并将所得溶液保持在高温下，例如在约20℃至约360℃的范围内，持续足够的时间以产生作为二元合金的纳米颗粒 的IV-VI要素。
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