-
公开(公告)号：US20110178065A1
公开(公告)日：2011-07-21
申请号：US13005646
申请日：2011-01-13
Applicant: Daniel Chu , Bing Wang , Tao Ye
Inventor： Daniel Chu , Bing Wang , Tao Ye
IPC: A61K31/55 , A61P35/00 , C12N9/99 , A61K31/366 , C07D335/04 , C07D405/08 , C07D487/04 , C07D333/50 , A61K31/365 , A61K31/443 , C07D401/08 , A61K31/497
CPC classification number: C07J73/003 , C07D211/76 , C07D233/60 , C07D241/12 , C07D249/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07J61/00 , C07J73/005 , C07J73/006 , C07J73/008
Abstract: Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.
Abstract translation: 本文提供了CYP17酶的抑制剂。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。
-
42.发明申请SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY 审中-公开具有抗生素活性的半合成重组型VANCOMYCIN / DESMETHYL-VANCOMYCIN型糖尿病公开(公告)号：US20080214444A1
公开(公告)日：2008-09-04
申请号：US12043076
申请日：2008-03-05
Applicant: Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Jian-Xin Wang
Inventor： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Jian-Xin Wang
CPC classification number: C07K9/008
Abstract: Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
Abstract translation: 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
-
公开(公告)号：US07332476B2
公开(公告)日：2008-02-19
申请号：US10831749
申请日：2004-04-23
Applicant: Matthew T. Burger , Georgia Law Carroll , Daniel Chu , Xiaodong Lin , Jacob Plattner , Alice Rico
Inventor： Matthew T. Burger , Georgia Law Carroll , Daniel Chu , Xiaodong Lin , Jacob Plattner , Alice Rico
CPC classification number: C07H17/08
Abstract: Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
Abstract translation: 提供抗微生物大环内酯和酮内酯化合物，其具有式XII：及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
-
公开(公告)号：USRE39762E1
公开(公告)日：2007-08-07
申请号：US11299244
申请日：2005-12-09
Applicant: Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
Inventor： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC: C07D515/00 , C07D498/00
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.
Abstract translation: 具有式但不包括FK-506，FK-520,18-羟基-FK520和18-羟基-FK-506的聚酮化合物。
-
45.发明申请公开(公告)号：US20070132831A1
公开(公告)日：2007-06-14
申请号：US11302695
申请日：2005-12-13
Applicant: Daniel Chu
Inventor： Daniel Chu
IPC: B41J15/14
CPC classification number: G01N21/253 , G01N2201/0446 , G01N2201/1042
Abstract: Scanning of a microarray is performed through a mask that exposes a plurality, but not all, of the sites of the microarray, and either the mask is movable relative to the microarray or the microarray is movable relative to the mask, or both. The mask is useful as a means of restricting the illumination of sites on the microarray to those that can be illuminated while the scan head is traveling at a steady, target velocity, blocking the passage of light between the scan head and the microarray at those points in the scan head trajectory where the scan head is either accelerating or decelerating. The mask is also useful for reducing background noise in the microarray image by preventing light spillage to sites adjacent to those being scanned.
Abstract translation: 微阵列的扫描通过暴露微阵列的多个但不是全部的掩模进行，并且掩模相对于微阵列是可移动的，或者微阵列相对于掩模或两者都是可移动的。 该掩模可用作将扫描头以稳定的目标速度行进的情况下将微阵列上的部位的照明限制在可照亮的位置的手段，阻止在那些点处扫描头和微阵列之间的光通过 在扫描头轨迹中扫描头正在加速或减速。 该掩模也可用于通过防止光泄漏到与扫描的那些相邻的位置来减少微阵列图像中的背景噪声。
-
Patent Agency Ranking
46.发明申请Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity 失效半合成重组万古霉素/脱甲基万古霉素类糖肽具有抗菌活性公开(公告)号：US20070021328A1
公开(公告)日：2007-01-25
申请号：US11361311
申请日：2006-02-24
Applicant: Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Wang
Inventor： Yaohui Lei , Yu Bai , Daniel Chu , Zhi-Jie Ni , John Wang
CPC classification number: C07K9/008
Abstract: Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
Abstract translation: 具有抗菌活性的半合成糖肽基于重排的万古霉素或去甲基 - 万古霉素支架的修饰，特别是在该支架上的具有某些酰基的氨基取代的糖部分上的氨基取代基的烷基化或酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
-
公开(公告)号：US20060276623A1
公开(公告)日：2006-12-07
申请号：US11361852
申请日：2006-02-24
Applicant: Daniel Chu , Maria Preobrazhenskaya , Svetlana Printsevskaya , Eugenia Olsufyeva
Inventor： Daniel Chu , Maria Preobrazhenskaya , Svetlana Printsevskaya , Eugenia Olsufyeva
Abstract: Semi-synthetic glycopeptides having antibacterial activity are based on modifications of the eremomycin, A82846B, vancomycin, teicoplanin, and A-40,926 scaffolds, in particular, acylation of the sugar moieties on these scaffolds with certain acyl groups; and/or conversion of an acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides; or having a combination of an alkylation modification of the amino substituent on the amino-substituted sugar moiety on these scaffolds with certain alkyl groups or acylation modification of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain alkyl groups, and conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
-
48.发明申请Power polarization beam combiner and its applications in fiber communication 失效功率偏振光束组合器及其在光纤通信中的应用公开(公告)号：US20050141893A1
公开(公告)日：2005-06-30
申请号：US10845093
申请日：2004-05-14
Applicant: Chih-Tsung Shih , Chen-Bin Huang , Daniel Chu , Yu-Chen Yu
Inventor： Chih-Tsung Shih , Chen-Bin Huang , Daniel Chu , Yu-Chen Yu
CPC classification number: G02B6/2726 , B82Y20/00 , G02B6/1225 , G02B6/2773
Abstract: This specification discloses a power polarization beam combiner and its applications in fiber communications. The power polarization beam combiner uses the photonic band gap formed in a photonic crystal to produce a left-hand material with a negative refractive index and high dispersion rate. Using such properties of the photonic crystal, several beams with different wavelengths and polarizations are combined and output to a common port.
Abstract translation: 本说明书公开了一种功率偏振光束组合器及其在光纤通信中的应用。 功率偏振光束组合器使用形成在光子晶体中的光子带隙产生具有负折射率和高色散速率的左手材料。 使用光子晶体的这种性质，将具有不同波长和偏振度的多个光束组合并输出到公共端口。
-
公开(公告)号：US20050124597A1
公开(公告)日：2005-06-09
申请号：US10503401
申请日：2003-02-03
Applicant: Rustum Boyce , Daniel Chu , David P. Lentini
Inventor： Rustum Boyce , Daniel Chu , David P. Lentini
CPC classification number: C07K5/06165 , A61K38/00 , C07K5/06139
Abstract: A variety of small, guanidino group-containing molecules capable of acting as MC4-R agonists are provided. The compounds have various structures provided herein. The compounds are useful in treating MC4-R mediated diseases and may be formulated into pharmaceutical formulations and compositions.
Abstract translation: 提供了能够作为MC4-R激动剂的各种含有胍基的小分子。 化合物具有本文提供的各种结构。 该化合物可用于治疗MC4-R介导的疾病，并且可以配制成药物制剂和组合物。
-
公开(公告)号：US20050009070A1
公开(公告)日：2005-01-13
申请号：US10851682
申请日：2004-05-21
Applicant: German Arciniegas , Jeff Ceremony , Daniel Chu , Charles Ragsdale
Inventor： German Arciniegas , Jeff Ceremony , Daniel Chu , Charles Ragsdale
CPC classification number: B01L7/54 , B01L3/50851 , B01L7/52 , B01L9/06 , B01L2300/044 , B01L2300/0829 , B01L2300/12 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2300/1883 , B01L2400/0475 , B01L2400/0487 , B01L2400/049
Abstract: Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.
Abstract translation: 在诸如多孔板的空间阵列中同时进行的多个反应中的单独温度控制通过具有单独控制的热电模块实现，每个模块从阵列内的单个区域提供热量或从其中提取热量，该区域包含 单反应容器或一组反应容器。
-
-
-
-
-
-
-
-
-
Search Results
86
records
(took 0.075 seconds)
