公开(公告)号：US20220246416A1

公开(公告)日：2022-08-04

申请号：US17674356

申请日：2022-02-17

Applicant: Elemental Scientific, Inc.

Inventor： Austin Schultz

IPC: H01J49/04 ,  H01J49/10 ,  G01N30/20

Abstract: Systems and methods are described to concentrate and homogenize a remote sample for analysis. A sample concentration and homogenization system embodiment includes, but is not limited to, at least a first valve, at least a first column fluidically coupled to the first valve, a flow meter fluidically coupled with the first column when the first valve is in a first flow path configuration to measure an amount of the liquid sample passed through the first column, and a homogenization valve including a sample homogenizing loop in which the concentrated sample is homogenized.

公开(公告)号：US11209343B1

公开(公告)日：2021-12-28

申请号：US15911554

申请日：2018-03-05

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: G01N1/00 ,  G01N1/28 ,  B01D19/00

Abstract: A method for detecting material in a sample using an ICP instrument includes preparing the sample for analysis by the ICP instrument using hydrogen gas. For example, hydrogen gas can be generated by initiating a hydride generation reaction with the sample. Further, hydrogen gas can be introduced to a component part of the sample. For instance, hydrogen gas can be added to an injector gas in a spray chamber of the ICP instrument.

公开(公告)号：US11056328B2

公开(公告)日：2021-07-06

申请号：US16833103

申请日：2020-03-27

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Kyle W. Uhlmeyer ,  Austin Schultz ,  Jonathan Hein

IPC: G01N1/38 ,  H01J49/04 ,  H01J49/00 ,  G01N35/10 ,  H01J49/10

Abstract: A sample introduction system providing variable online dilution of a sample is described. In one or more implementations, a device includes a spectrometry analysis system that employs example techniques in accordance with the present disclosure includes an inline dilution environment, including a first valve assembly configured to prepare a sample by accepting at least one of the sample, a diluent, a carrier, or an internal standard, where the first valve assembly includes a first sample loop; and a second valve assembly configured to prepare the sample by accepting the sample from the first valve assembly, where the second valve assembly is coupled to the first valve assembly, and where the second valve assembly includes a second sample loop.

公开(公告)号：US10828634B2

公开(公告)日：2020-11-10

申请号：US16709250

申请日：2019-12-10

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: G01N35/10 ,  B01L3/00 ,  G01N1/38 ,  G01N21/73 ,  H01J49/04 ,  H01J49/10 ,  G01N21/71

Abstract: Sample preparation systems and methods are described having pump control, valve configurations, and control logic that facilitate automatic, inline preparation dilutions of a sample according to at least two dilution operating modes. A system embodiment includes, but is not limited to a first pump configured to drive a carrier fluid; a second pump configured to drive a diluent; and a plurality of selection valves fluidically coupled with the first pump and the second pump, the plurality of selection valves being configured to direct fluid flows from the first pump and the second pump according to at least two modes of operation to provide a single-stage sample dilution according to a first operating mode and to provide a dual-stage sample dilution according to a second operating mode.

公开(公告)号：US10340832B2

公开(公告)日：2019-07-02

申请号：US15688396

申请日：2017-08-28

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: A61L2/00 ,  F16K31/12 ,  H02P25/18 ,  G01N21/71 ,  G01N21/73 ,  C01B6/06 ,  C01B6/10 ,  B63H21/14 ,  B63H21/20 ,  B63H23/10 ,  H02K3/28 ,  H02K7/18 ,  H02K16/04 ,  H02K19/16 ,  H02K21/02 ,  H02P31/00

Abstract: The present disclosure is directed to a system and a method for hydride generation. In some embodiments, the system includes an assembly for introducing hydride generation reagents into a mixing path or mixing container, where the assembly includes first chamber configured to contain a first hydride generation reagent and a second chamber configured to contain a second hydride generation reagent. A first plunger is configured to translate within the first chamber and cause a displacement of the first hydride generation reagent, and a second plunger is configured to translate within the second chamber and cause a displacement of the second hydride generation reagent. The assembly further includes base coupling the first plunger and the second plunger together.

公开(公告)号：US20190070601A1

公开(公告)日：2019-03-07

申请号：US16119228

申请日：2018-08-31

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: B01L3/00 ,  G01N1/38 ,  G01N21/73 ,  H01J49/10 ,  H01J49/04

Abstract: Sample preparation systems and methods are described having pump control, valve configurations, and control logic that facilitate automatic, inline preparation dilutions of a sample according to at least two dilution operating modes. A system embodiment includes, but is not limited to a first pump configured to drive a carrier fluid; a second pump configured to drive a diluent; and a plurality of selection valves fluidically coupled with the first pump and the second pump, the plurality of selection valves being configured to direct fluid flows from the first pump and the second pump according to at least two modes of operation to provide a single-stage sample dilution according to a first operating mode and to provide a dual-stage sample dilution according to a second operating mode.

公开(公告)号：US09343283B1

公开(公告)日：2016-05-17

申请号：US14830601

申请日：2015-08-19

Applicant: Elemental Scientific, Inc.

Inventor： Paul Field ,  Daniel R. Wiederin ,  Austin Schultz

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/105 ,  H01J49/0009

Abstract: A method for internal standardization of cool plasma ICP-MS using one or more enriched stable isotopes includes introducing an enriched stable isotope of a chemical species to a sample containing a non-enriched isotope of the chemical species to form a sample and standard mixture. In implementations, the enriched stable isotope is introduced via an inline syringe addition to a flow of a sample solution containing a non-enriched isotope of the chemical species to be analyzed. The method also includes introducing the sample and standard mixture to an ICP-MS under cool plasma conditions. The method also includes determining an ionization amount of the enriched stable isotope by the ICP-MS. The method further includes correlating an ionization amount of the non-enriched isotope based on the determined ionization amount of the enriched stable isotope.

Abstract translation: 使用一种或多种富集的稳定同位素的冷等离子体ICP-MS的内部标准化方法包括将含有化学物质的富集的稳定同位素引入到含有化学物质的非富集同位素的样品中以形成样品和标准混合物。 在实施方案中，将富集的稳定同位素通过在线注射器加入到含有要分析的化学物质的非富集同位素的样品溶液的流中。 该方法还包括在冷等离子体条件下将样品和标准混合物引入ICP-MS。 该方法还包括通过ICP-MS确定富集的稳定同位素的电离量。 该方法还包括基于所确定的富集的稳定同位素的电离量来关联非富集同位素的电离量。

公开(公告)号：US20160056028A1

公开(公告)日：2016-02-25

申请号：US14830063

申请日：2015-08-19

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: H01J49/04 ,  F17D3/01 ,  F15D1/06 ,  H01J49/10 ,  B01D15/36

CPC classification number: F17D3/01 ,  B01D15/361 ,  F15D1/06 ,  H01J49/105

Abstract: A system can include a valve assembly including a first valve and a second valve in fluid communication with the first valve. The valve assembly can be configured to deliver one or more of a sample, a chemical (e.g., an acid, a base, an organic chemical, etc.), and a standard via flow of a working fluid facilitated by one or more syringe pumps. Further, the one or more of the sample, the chemical, and the standard can maintain a physical separation from the one or more syringe pumps during delivery of the one or more of the sample, the chemical, and the standard.

Abstract translation: 系统可以包括阀组件，其包括与第一阀流体连通的第一阀和第二阀。 阀组件可以被配置成输送一个或多个样品，化学物质（例如酸，碱，有机化学物质等）和由一个或多个注射器泵促进的工作流体的标准通过流 。 此外，样品，化学品和标准品中的一种或多种可以在一个或多个样品，化学品和标准品的输送期间保持与一个或多个注射器泵的物理分离。

公开(公告)号：US09177772B1

公开(公告)日：2015-11-03

申请号：US13656978

申请日：2012-10-22

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: H01J49/04 ,  H01J49/10

CPC classification number: G05D11/02 ,  H01J49/0413 ,  H01J49/045 ,  H01J49/105

Abstract: A sample introduction system providing intermittent or discontinuous supply of liquid to a nebulizer is described. In one or more implementations, the sample introduction system includes a nebulizer configured to receive a fluid sample and a nebulizer gas and aerosolize the fluid sample with the nebulizer gas. The sample introduction system also includes a sample pump configured to supply a first aliquot of a sample to the nebulizer during a first time interval, stop supplying the first aliquot of the sample at the end of the first time interval, supply at least substantially no sample to the nebulizer during a second time interval subsequent to the first time interval, and supply a second aliquot of a sample to the nebulizer during a third time interval subsequent to the second time interval.

Abstract translation: 描述了向雾化器提供间歇或不连续供应液体的样品引入系统。 在一个或多个实施方案中，样品引入系统包括构造成接收流体样品和喷雾器气体并且用喷雾器气雾化流体样品的雾化器。 样品引入系统还包括样品泵，其构造成在第一时间间隔期间将样品的第一等分试样提供给喷雾器，停止在第一时间间隔结束时提供样品的第一等分试样，至少基本上不提供样品 在所述第一时间间隔之后的第二时间间隔期间到所述雾化器，并且在所述第二时间间隔之后的第三时间间隔期间将样品的第二等分试样提供给所述雾化器。