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114 条记录 (耗时 0.031 秒)

    Methods and compositions related to targeting wounds, regenerating tissue, and tumors
    42.
    发明授权
    Methods and compositions related to targeting wounds, regenerating tissue, and tumors 有权
    与创伤，再生组织和肿瘤相关的方法和组合物

    公开(公告)号：US08188220B2

    公开(公告)日：2012-05-29

    申请号：US11951819

    申请日：2007-12-06

    申请人： Erkki Ruoslahti ,  Tero Jarvinen

    发明人： Erkki Ruoslahti ,  Tero Jarvinen

    IPC分类号： C07K16/00

    CPC分类号： C07K7/06 ,  A61K38/00

    摘要： Disclosed are compositions and methods useful for targeting regenerating tissue, wounds, and tumors. The compositions and methods are based on peptide sequences that selectively bind to and home to regenerating tissue, wound sites, and tumors in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to regenerating tissue, wound sites, and tumors in animals.

    摘要翻译： 公开了用于靶向再生组织，伤口和肿瘤的组合物和方法。 组合物和方法基于肽序列，其选择性地结合并在家中在动物中再生组织，伤口部位和肿瘤。 所公开的靶向对于递送治疗和可检测的药剂以在动物中再生组织，伤口部位和肿瘤是有用的。

    NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
    45.
    发明申请
    NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same 审中-公开

    公开(公告)号：US20090257951A1

    公开(公告)日：2009-10-15

    申请号：US11977653

    申请日：2007-10-24

    申请人： Erkki Ruoslahti ,  Renata Pasqualini

    发明人： Erkki Ruoslahti ,  Renata Pasqualini

    IPC分类号： A61K51/08 ,  A61K38/14 ,  A61K51/02 ,  A61K31/704

    CPC分类号： G01N33/5011 ,  G01N33/57492 ,  G01N2333/70546 ,  G01N2333/948

    摘要： The present invention provides a method of identifying a tumor homing molecule that homes to angiogenic vasculature by contacting a substantially purified NGR receptor with one or more molecules and determining specific binding of a molecule to the NGR receptor, where the presence of specific binding identifies the molecule as a tumor homing molecule that homes to angiogenic vasculature. The invention also provides a method of directing a moiety to angiogenic vasculature in a subject by administering to the subject a conjugate including a moiety linked to a tumor homing molecule that exhibits specific binding to an NGR receptor, whereby the moiety is directed to angiogenic vasculature. In addition, the invention provides a method of imaging the angiogenic vasculature of a tumor in a subject by administering to the subject a conjugate having a detectable moiety linked to a tumor homing molecule that exhibits specific binding to an NGR receptor and detecting the conjugate.

    Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
    48.
    发明申请
    Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs 失效
    选择性地归属于胰腺和其他器官的恶变或恶性病变脉管系统的分子

    公开(公告)号：US20050245445A1

    公开(公告)日：2005-11-03

    申请号：US10977367

    申请日：2004-10-29

    申请人： Douglas Hanahan ,  Erkki Ruoslahti ,  Johanna Joyce ,  Pirjo Laakkonen

    发明人： Douglas Hanahan ,  Erkki Ruoslahti ,  Johanna Joyce ,  Pirjo Laakkonen

    IPC分类号： A61K20060101 ,  A61K38/00 ,  A61K47/48 ,  A61K49/00 ,  C07K5/00 ,  C07K7/06 ,  C07K14/47

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K47/62 ,  A61K49/0043 ,  A61K49/0056 ,  C07K7/06

    摘要： The invention provides a conjugate that includes a therapeutic moiety linked to a peptide or peptidomimetic that selectively homes to vasculature of premalignant pancreas. The peptide or peptidomimetic contains at least 5 contiguous amino acids of an amino acid sequence selected from CRSRKG (SEQ ID NO:9) and CEYQLDVE (SEQ ID NO:34), or a conservative variant or peptidomimetic thereof. The invention additionally provides a conjugate containing a therapeutic moiety linked to a peptide or peptidomimetic that selectively homes to pancreatic tumor cells and pancreatic tumor vasculature, the peptide or peptidomimetic comprising at least 5 contiguous amino acids of an amino acid sequence selected from CKAAKNK (SEQ ID NO:15), CKGAKAR (SEQ ID NO:19), and VGVGEWSV (SEQ ID NO:35), or a conservative variant or peptidomimetic thereof.

    摘要翻译： 本发明提供了一种缀合物，其包括与肽或肽模拟物连接的治疗部分，其选择性地归属于恶化前胰腺的脉管系统。 肽或肽模拟物含有选自CRSRKG（SEQ ID NO：9）和CEYQLDVE（SEQ ID NO：34）的氨基酸序列的至少5个连续氨基酸，或其保守变体或肽模拟物。 本发明另外提供了一种缀合物，其含有与肽或肽模拟物连接的治疗部分，其选择性地置于胰腺肿瘤细胞和胰腺肿瘤血管系统中，所述肽或肽模拟物包含选自以下的氨基酸序列的至少5个连续氨基酸：SEQ ID NO： NO：15），CKGAKAR（SEQ ID NO：19）和VGVGEWSV（SEQ ID NO：35），或其保守变体或肽模拟物。

    Molecules that home to various selected organs or tissues
    49.
    发明授权
    Molecules that home to various selected organs or tissues 失效
    归属于各种选定器官或组织的分子

    公开(公告)号：US06933281B2

    公开(公告)日：2005-08-23

    申请号：US10607595

    申请日：2003-06-27

    申请人： Erkki Ruoslahti ,  Renata Pasqualini

    发明人： Erkki Ruoslahti ,  Renata Pasqualini

    IPC分类号： A61K31/195 ,  A61K38/00 ,  A61K47/48 ,  C07K7/06 ,  C07K7/08 ,  A61K38/08 ,  G01N33/566

    CPC分类号： C07K7/06 ,  A61K31/195 ,  A61K38/00 ,  A61K47/6425 ,  C07K7/08 ,  Y10S977/808 ,  Y10S977/911 ,  Y10S977/912

    摘要： The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.

    摘要翻译： 本发明提供了选择性地归属于各种正常器官或组织，包括肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠道的分子; 并提供选择性地置于携带肿瘤的器官或组织，包括携带胰腺肿瘤的胰腺或携带肺肿瘤的肺的分子。 本发明还提供缀合物，其包含与部分连接的器官或组织归巢分子。 这样的部分可以是例如治疗剂或可检测剂。 此外，本发明提供使用本发明的器官归巢分子通过使器官或组织与本发明的分子接触来鉴定特定器官或组织的方法。 本发明还提供了通过对具有或怀疑具有病理学病理学的受试者进行诊断或治疗肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠道的病理学的方法 到选定的器官或组织。 本发明还提供鉴定肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠内的靶分子的方法。