利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.028 秒)

    Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents
    5.
    发明申请
    Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents 审中-公开
    癌原体肽与细胞穿透肽之间的嵌合构建体与抗癌药物和/或诊断剂/药剂偶联

    公开(公告)号：US20100279918A1

    公开(公告)日：2010-11-04

    申请号：US12225367

    申请日：2007-03-20

    申请人： Ülo Langel ,  Erkki Ruoslahti ,  Helena Myrberg ,  Maarja Mäe ,  Lianglin Zhang

    发明人： Ülo Langel ,  Erkki Ruoslahti ,  Helena Myrberg ,  Maarja Mäe ,  Lianglin Zhang

    IPC分类号： A61K38/00 ,  C07K2/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K7/08 ,  A61P35/04 ,  C12N5/02

    CPC分类号： A61K49/0056 ,  A61K47/64 ,  A61K49/0043

    摘要： A construct comprising a cancer-homing peptide, an optional linker and a cell-penetrating peptide coupled to an anticancer drug and/or a diagnostic agent is disclosed. The homing peptide is for example a linear pentapeptide such as CREKA (SEQ ID NO:1), AREKA (SEQ 5 ID NO: 23) or CREKA0 (SEQ ID NO: 23), or a cyclic nonapeptide CPGPEGAGC (SEQ ID NO:2), and the cell-penetrating peptide is for example one of the peptides SEQ ID NO:3-SEQ ID NO:20. The anticancer drug may be selected from alkylating agents, antimetabolites and cytotoxic antibiotics, and the diagnostic agent may be a fluorescent label. Further, a method of delivering an anticancer drug and/or a diagnostic agent into a cancer cell 0 comprising administration of a construct according to the invention in vivo or in vitro is described.

    摘要翻译： 公开了包含癌抗原肽，任选接头和与抗癌药物和/或诊断剂偶联的细胞穿透肽的构建体。 归巢肽例如是诸如CREKA（SEQ ID NO：1），AREKA（SEQ ID NO：23）或CREKA0（SEQ ID NO：23）的线性五肽，或环状肽PGPEGAGC（SEQ ID NO：2 ），并且细胞穿透肽是例如肽SEQ ID NO：3-SEQ ID NO：20之一。 抗癌药物可以选自烷化剂，抗代谢物和细胞毒性抗生素，诊断剂可以是荧光标记物。 此外，描述了将抗癌药物和/或诊断剂递送到癌细胞0中的方法，包括在体内或体外施用本发明的构建体。

    Peptides that selectively home to heart vasculature and related conjugates and methods
    6.
    发明申请
    Peptides that selectively home to heart vasculature and related conjugates and methods 有权
    选择性地置于心脏血管和相关共轭物和方法的肽

    公开(公告)号：US20090191223A1

    公开(公告)日：2009-07-30

    申请号：US12322371

    申请日：2009-01-29

    申请人： Lianglin Zhang ,  Jason A. Hoffman ,  Erkki Ruoslahti

    发明人： Lianglin Zhang ,  Jason A. Hoffman ,  Erkki Ruoslahti

    IPC分类号： A61K39/395 ,  C07K7/06 ,  A61K38/08 ,  A61P7/02

    CPC分类号： A61K47/48246 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K47/6849 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

    摘要： The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof.

    摘要翻译： 本发明提供了多种分离的肽和肽模拟物，其可用于构建本发明的缀合物，或其中肽本身具有生物学活性的非共轭形式作为治疗各种各样的 心血管疾病如下所述。 因此，本发明提供长度小于60个残基的分离的肽或肽模拟物，并且包括氨基酸序列CRPPR（SEQ ID NO：1）或其肽模拟物。 本发明还提供长度小于60个残基的分离的肽或肽模拟物，包括氨基酸序列CARPAR（SEQ ID NO：5）或其拟肽，或氨基酸序列CPKRPR（SEQ ID NO：6）或 其拟肽。

    Peptides that selectively home to heart vasculature and related conjugates and methods
    8.
    发明授权
    Peptides that selectively home to heart vasculature and related conjugates and methods 有权
    选择性地置于心脏血管和相关共轭物和方法的肽

    公开(公告)号：US08637635B2

    公开(公告)日：2014-01-28

    申请号：US12322371

    申请日：2009-01-29

    申请人： Lianglin Zhang ,  Jason A. Hoffman ,  Erkki Ruoslahti

    发明人： Lianglin Zhang ,  Jason A. Hoffman ,  Erkki Ruoslahti

    IPC分类号： A61K38/04 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  A61K51/00

    CPC分类号： A61K47/48246 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K47/6849 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

    摘要： The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a varirty of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimtic thereof.

    摘要翻译： 本发明提供了多种分离的肽和肽模拟物，其可用于例如构建本发明的缀合物，或其中肽本身具有生物学活性的非结合形式作为治疗剂，用于治疗任何一种 心血管疾病如下所述。 因此，本发明提供长度小于60个残基的分离的肽或肽模拟物，并且包括氨基酸序列CRPPR（SEQ ID NO：1）或其肽模拟物。 本发明还提供长度小于60个残基的分离的肽或肽模拟物，包括氨基酸序列CARPAR（SEQ ID NO：5）或其拟肽，或氨基酸序列CPKRPR（SEQ ID NO：6）或 它的一个peptidmimtic它。