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41.发明授权High amine content polymer coatings for implantable devices and a method of forming the same 有权用于可植入装置的高胺含量聚合物涂层及其形成方法公开(公告)号：US08206733B2
公开(公告)日：2012-06-26
申请号：US12723552
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US08197499B2
公开(公告)日：2012-06-12
申请号：US12340588
申请日：2008-12-19
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
IPC分类号： A61B17/08
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
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公开(公告)号：US20100198339A1
公开(公告)日：2010-08-05
申请号：US12723534
申请日：2010-03-12
申请人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
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公开(公告)号：US07008411B1
公开(公告)日：2006-03-07
申请号：US10262151
申请日：2002-09-30
CPC分类号： A61M25/0084 , A61B2017/22081 , A61M25/0026 , A61M25/1006 , A61M2025/0096
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.
摘要翻译： 一种治疗易损斑块的装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送生物活性剂以稳定易损斑块。
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45.发明授权Biocompatible carrier containing actinomycin D and a method of forming the same 有权含有放线菌素D的生物相容性载体及其形成方法公开(公告)号：US06503954B1
公开(公告)日：2003-01-07
申请号：US09621123
申请日：2000-07-21
申请人： Vinayak D. Bhat , Syed F. A. Hossainy , Daryush Mirzaee , Evgenia Mandrusov , Deborra Sanders-Millare , Judy A. Guruwaiya
发明人： Vinayak D. Bhat , Syed F. A. Hossainy , Daryush Mirzaee , Evgenia Mandrusov , Deborra Sanders-Millare , Judy A. Guruwaiya
IPC分类号： A61K4730
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/406 , A61L2300/416 , A61L2300/606 , A61L2300/608 , C08L29/04
摘要： A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local delivery and sustained release of actinomycin D. The carrier can be formed from the ethylene vinyl alcohol, copolymer, a dimethylsulfoxide solvent, and actinomycin D. Alternatively, the carrier can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, actinornycin D, and a wetting fluid. The carrier can serve as a coating for a prosthesis, for example a stent. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.
摘要翻译： 公开了生物相容性载体和用于形成载体的组合物。 载体由可用作储存器的乙烯乙烯醇共聚物制成，允许放线菌素D的局部递送和持续释放。载体可以由乙烯乙烯醇，共聚物，二甲基亚砜溶剂和放线菌素D形成。 或者，载体可以由乙烯乙烯醇共聚物，二甲基亚砜溶剂，放线菌素D和润湿流体形成。 载体可以用作假体（例如支架）的涂层。 将组合物施加到假体的表面，并且基本上所有的二甲基亚砜溶剂或二甲基亚砜溶剂/润湿流体被去除或允许蒸发以形成涂层。
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46.发明授权Integrated system for on-site mononuclear cell acquisition, processing and delivery 有权用于现场单核细胞获取，处理和递送的综合系统公开(公告)号：US08968991B2
公开(公告)日：2015-03-03
申请号：US12070234
申请日：2008-02-15
申请人： Evgenia Mandrusov , Albert K. Chin , William Earl Webler, Jr. , Yan Shen , Robert D. Alnsworth , Eugene Michal
发明人： Evgenia Mandrusov , Albert K. Chin , William Earl Webler, Jr. , Yan Shen , Robert D. Alnsworth , Eugene Michal
CPC分类号： A61B17/3472 , A61B1/015 , A61B1/313 , A61B2017/00969 , A61B2217/005 , A61K35/28 , A61K2035/124 , A61M5/00 , A61M2202/10 , A61M2210/02 , A61M2210/125
摘要： Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.
摘要翻译： 描述了用于治疗心脏组织的系统和方法的许多实施例。 在一个实施方案中，从患者中提取骨髓细胞。 然后处理细胞以分离单核细胞，其然后可以在患者的心脏组织附近被递送回来。
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47.发明授权公开(公告)号：US08608661B1
公开(公告)日：2013-12-17
申请号：US10792960
申请日：2004-03-03
IPC分类号： A61B8/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/02007 , A61B5/4839 , A61B17/3478 , A61B2017/00247 , A61B2017/22082 , A61B2090/3735 , Y10S977/905 , Y10S977/915
摘要： A method including positioning a delivery device at a location in a blood vessel; advancing the delivery device a distance into a wall of the blood vessel to a treatment site beyond an external elastic lamina of the blood vessel; and after advancing the delivery device, introducing a treatment agent including a cellular component through the delivery device. A composition including a treatment agent comprising a cellular component associated with a matrix material, wherein the composition is suitable for percutaneous delivery. Also an apparatus suitable for delivering a treatment agent. Also, a kit including a treatment agent.
摘要翻译： 一种包括将输送装置定位在血管中的位置的方法; 将输送装置推进到血管壁的距离超过血管的外部弹性层的治疗部位; 并且在推进传送装置之后，通过传送装置引入包括蜂窝部件的处理剂。 一种组合物，其包含包含与基质材料相关的细胞成分的处理剂，其中所述组合物适于经皮递送。 也是适用于递送治疗剂的装置。 另外，还可以使用包含处理剂的试剂盒。
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公开(公告)号：US08383142B2
公开(公告)日：2013-02-26
申请号：US12723556
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US20100198342A1
公开(公告)日：2010-08-05
申请号：US12723565
申请日：2010-03-12
申请人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F.A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
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公开(公告)号：US20090187199A1
公开(公告)日：2009-07-23
申请号：US12340588
申请日：2008-12-19
申请人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
发明人： Geoffrey C. Gurtner , Gerald G. Fuller , Michael T. Longaker , Jayakumar Rajadas , Gordon Saul , C. Travis Rappleye , Evgenia Mandrusov
CPC分类号： A61B17/00491 , A61B17/04 , A61B17/11 , A61B17/122 , A61B17/1227 , A61B2017/1103 , A61B2017/1107
摘要： Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
摘要翻译： 公开了用于将非结合腔内连接在患者体内（包括血管内腔）的组合物，方法和试剂盒。 更具体地，在各个方面，本发明提供了用于连接这种非结合腔的组合物，方法和试剂盒，包括通常需要显微外科技术的小腔。
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