公开(公告)号：US20190315785A1

公开(公告)日：2019-10-17

申请号：US16195152

申请日：2018-11-19

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20190275063A1

公开(公告)日：2019-09-12

申请号：US16274049

申请日：2019-02-12

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/683 ,  A61K31/706 ,  A61K31/6615 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K31/53 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00 ,  C07D487/04 ,  A61K31/00 ,  A61K45/06 ,  A61K31/7056 ,  A61K31/665

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20190055251A1

公开(公告)日：2019-02-21

申请号：US16042085

申请日：2018-07-23

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H7/06 ,  A61K45/06 ,  A61K31/706 ,  C07F9/6561 ,  C07H19/04 ,  A61K9/00

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US20170210770A1

公开(公告)日：2017-07-27

申请号：US15402857

申请日：2017-01-10

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US09457035B2

公开(公告)日：2016-10-04

申请号：US14178237

申请日：2014-02-11

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07H19/04 ,  A61K31/675 ,  A61K31/662 ,  C07F9/6561 ,  C07H19/00 ,  A61K45/06 ,  C07H19/20

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20150152116A1

公开(公告)日：2015-06-04

申请号：US14613719

申请日：2015-02-04

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07F9/6561

CPC classification number: C07D487/04 ,  A61K9/0078 ,  A61K31/706 ,  A61K45/06 ,  C07F9/6561 ,  C07H7/06 ,  C07H19/04

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.