公开(公告)号：US20100100668A1

公开(公告)日：2010-04-22

申请号：US12648167

申请日：2009-12-28

申请人： He Huang

发明人： He Huang

IPC分类号： G06F12/02

CPC分类号： G06F12/0246 ,  G06F2212/7208

摘要： A control method for logical strips based on a multi-channel solid-state non-volatile storage device is provided. The method includes the following processing steps. In Step 1, a storage space of every channel is partitioned into a plurality of storage units of equal size. In Step 2, at least one logical strip is set by which the storage units with discrete physical addresses across a plurality of channels are organized into a continuous logical space. In Step 3, during data reading/writing operation, the data is divided according to a size of each local strip, the divided data is mapped to the storage units of every channel, and a parallel reading/writing operation is performed across the channels. This method may increase the efficiency of reading and writing operations of the storage device and prolong the operating life span of the device.

摘要翻译： 提供了一种基于多通道固态非易失性存储设备的逻辑条带控制方法。 该方法包括以下处理步骤。 在步骤1中，每个信道的存储空间被划分成多个相同大小的存储单元。 在步骤2中，设置至少一个逻辑条，通过该逻辑条将具有跨多个信道的离散物理地址的存储单元组织成连续的逻辑空间。 在步骤3中，在数据读取/写入操作期间，根据每个本地条带的大小来分割数据，将分割的数据映射到每个通道的存储单元，并且跨信道执行并行读/写操作。 该方法可以提高存储设备的读写操作的效率，并延长设备的使用寿命。

公开(公告)号：US20090271567A1

公开(公告)日：2009-10-29

申请号：US12497368

申请日：2009-07-02

申请人： He Huang

发明人： He Huang

IPC分类号： G06F12/00 ,  G06F12/02

CPC分类号： G06F12/0246 ,  G06F2212/1016 ,  G06F2212/1036 ,  G06F2212/7201 ,  G06F2212/7211

摘要： A method for managing blocks in a flash memory is provided, which includes dynamic and static block managing methods. In the dynamic block managing method, a blank block is selected as a swap block for write operation. During each write operation, new data and/or original data in an object block to be operated are written into the swap block, and the object block is erased. Then, a logical address of the object block is changed to be a logical address of the swap block, so that the object block served as the swap block for a next write operation. In the static block managing method, a variable seed parameter is set. Different values of the seed parameter are each associated with a logical address of a respective flash memory block. When the value of the seed parameter varies, data in the flash memory block and the swap block associated to the value of the seed parameter are exchanged, so that the flash memory block associated to the value of the seed parameter becomes the swap block for the next write operation.

摘要翻译： 提供了一种用于管理闪存中的块的方法，其包括动态和静态块管理方法。 在动态块管理方法中，选择空白块作为写操作的交换块。 在每个写入操作期间，将要操作的对象块中的新数据和/或原始数据写入交换块，并且擦除对象块。 然后，将对象块的逻辑地址改变为交换块的逻辑地址，使得对象块用作下一个写入操作的交换块。 在静态块管理方法中，设置变量种子参数。 种子参数的不同值各自与相应闪存块的逻辑地址相关联。 当种子参数的值变化时，交换闪存块和与种子参数的值相关联的交换块中的数据，使得与种子参数的值相关联的闪存块成为用于 下一个写操作。

公开(公告)号：US07334407B2

公开(公告)日：2008-02-26

申请号：US10805786

申请日：2004-03-22

申请人： Louis J. Spadaccini ,  He Huang ,  David R. Sobel

发明人： Louis J. Spadaccini ,  He Huang ,  David R. Sobel

IPC分类号： F23R3/40

CPC分类号： B01D19/0031 ,  B01J19/0026 ,  B01J2208/00309 ,  B01J2208/00628 ,  B01J2208/00637 ,  B01J2208/00707 ,  B01J2219/00117

摘要： A fuel system for a propulsion system includes a fuel deoxygenating device and a catalytic module containing catalytic materials. The fuel deoxygenating device removes dissolved oxygen from the fuel to prevent formation of insoluble materials that can potentially foul the catalyst and block desirable catalytic reactions that increase the usable cooling capacity of an endothermic fuel.

摘要翻译： 用于推进系统的燃料系统包括燃料脱氧装置和包含催化材料的催化组件。 燃料脱氧装置从燃料中除去溶解氧以防止形成不可能的物质，这些物质可能潜在地污染催化剂并堵塞提高吸热燃料的可用冷却能力的所需催化反应。

公开(公告)号：US07211597B2

公开(公告)日：2007-05-01

申请号：US10247028

申请日：2002-09-19

申请人： Suzanne Metz ,  Michael Clare ,  Joyce Z. Crich ,  Timothy J. Hagen ,  Gunnar J. Hanson ,  He Huang ,  Stephen C. Houdek ,  Michael A. Stealey ,  Michael L. Vazquez ,  Richard M. Weier ,  Xiangdong Xu

发明人： Suzanne Metz ,  Michael Clare ,  Joyce Z. Crich ,  Timothy J. Hagen ,  Gunnar J. Hanson ,  He Huang ,  Stephen C. Houdek ,  Michael A. Stealey ,  Michael L. Vazquez ,  Richard M. Weier ,  Xiangdong Xu

IPC分类号： C07D491/052 ,  C07D471/04 ,  A61K31/4162 ,  A61K31/437 ,  A61K29/00

CPC分类号： C07D231/56 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14

摘要： The present invention relates to compounds of Formula I: wherein A is (CH2)m-Q-(CH2)n, wherein each CH2 may be independently substituted with one or more substitution selected from the group consisting of: hydroxy, halo, alkoxy, lower alkyl, amino, aminoalkyl, alkylamino, alkenyl, and alkynyl; B is a 5 or 6 membered heteroaryl, or aryl, optionally saturated, or optionally substituted with R1, R2, or R12; X is selected from the group consisting of: N and C; and Y and Z are independently selected from the group consisting of: N, C, CH, CR3, S, and O; compositions comprising such compounds, intermediates thereof, methods of making such compounds, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

摘要翻译： 本发明涉及式I的化合物：其中A是（CH 2）2 - （CH 2 CH 2）n 其中每个CH 2可以独立地被一个或多个选自以下的取代基取代：羟基，卤素，烷氧基，低级烷基，氨基，氨基烷基，烷基氨基，烯基和 炔基; B是任选被饱和或任选被R 1，R 2或R 12取代的5或6元杂芳基或芳基; X选自：N和C; 且Y和Z独立地选自：N，C，CH，CR 3，S和O; 包含这些化合物的组合物，其中间体，制备此类化合物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

公开(公告)号：US07186743B2

公开(公告)日：2007-03-06

申请号：US11113926

申请日：2005-04-25

申请人： Arija A. Bergmanis ,  Michael Clare ,  Joyce Z. Crich ,  Lifeng Geng ,  Timothy J. Hagen ,  Gunnar J. Hanson ,  Stephen C. Houdek ,  He Huang ,  Donna M. Iula ,  Francis J. Koszyk ,  Shuyuan Liao ,  Scott B. Mohler ,  Maria Nguyen ,  Richard A. Partis ,  Michael A. Stealey ,  Michael B. Tollefson ,  Richard M. Weier ,  Xiangdong Xu ,  Dominique Bonafoux ,  Theresa R. Fletcher ,  Bruce C Hamper ,  Patrick J. Lennon ,  Subo Liao ,  Suzanne Metz ,  David S. Oburn ,  Thomas J. Owen ,  Angela M. Scates ,  Michael L. Vazquez ,  Serge G. Wolfson

发明人： Arija A. Bergmanis ,  Michael Clare ,  Joyce Z. Crich ,  Lifeng Geng ,  Timothy J. Hagen ,  Gunnar J. Hanson ,  Stephen C. Houdek ,  He Huang ,  Donna M. Iula ,  Francis J. Koszyk ,  Shuyuan Liao ,  Scott B. Mohler ,  Maria Nguyen ,  Richard A. Partis ,  Michael A. Stealey ,  Michael B. Tollefson ,  Richard M. Weier ,  Xiangdong Xu ,  Dominique Bonafoux ,  Theresa R. Fletcher ,  Bruce C Hamper ,  Patrick J. Lennon ,  Subo Liao ,  Suzanne Metz ,  David S. Oburn ,  Thomas J. Owen ,  Angela M. Scates ,  Michael L. Vazquez ,  Serge G. Wolfson

IPC分类号： A61K31/416 ,  A61K31/454 ,  A61K31/5395 ,  A61K31/429 ,  A61K31/433 ,  A61K31/506 ,  A61K31/496

CPC分类号： C07D403/12 ,  C07D231/54 ,  C07D333/62 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

摘要翻译： 本发明涉及取代的吡唑基衍生物，包含这些的组合物，中间体，制备取代的吡唑基衍生物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

公开(公告)号：US20060213813A1

公开(公告)日：2006-09-28

申请号：US11302106

申请日：2005-12-13

申请人： He Huang ,  Zissis Dardas ,  Roger Lesieur

发明人： He Huang ,  Zissis Dardas ,  Roger Lesieur

IPC分类号： C10G45/00 ,  C10G17/00

CPC分类号： B01J20/28045 ,  B01J19/2485 ,  B01J19/249 ,  B01J19/2495 ,  B01J20/02 ,  B01J20/06 ,  B01J20/08 ,  B01J20/103 ,  B01J20/28014 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28097 ,  B01J20/3042 ,  B01J20/3204 ,  B01J20/3236 ,  B01J20/3289 ,  B01J20/3293 ,  B01J23/755 ,  B01J35/04 ,  B01J37/0215 ,  B01J2208/00132 ,  B01J2208/0015 ,  B01J2219/00081 ,  B01J2219/00085 ,  B01J2219/2453 ,  B01J2219/2458 ,  B01J2219/2459 ,  B01J2219/2479 ,  B01J2219/2485 ,  B01J2220/42 ,  C10G25/003 ,  C10G29/04 ,  H01M8/0675

摘要： A sulfur scrubbing method and structure is operable to remove substantially all of the sulfur present in an undiluted oxygenated hydrocarbon fuel stock supply which can be used to power an internal combustion engine or a fuel cell power plant in a mobile environment, such as an automobile, bus, truck, boat, or the like, or in a stationary environment. The fuel stock can be gasoline, diesel fuel, or other like fuels which contain relatively high levels of organic sulfur compounds such as mercaptans, sulfides, disulfides, thiophenes, and the like. The undiluted hydrocarbon fuel supply is passed through a desulfurizer bed which is provided with a high surface area nickel reactant, and wherein essentially all of the nickel reactant in the scrubber bed reacts with sulfur in the fuel stream, so as to remove sulfur from the fuel stream by converting it to nickel sulfide on the scrubber bed. The desulfurized organic remnants of the fuel stream continue through the remainder of the fuel processing system in the fuel cell power plant, or through the internal combustion engine. The desulfurizer bed is preferably formed from a high surface area ceramic foam monolith, the pores of which are coated with the high surface area nickel reactant. The use of the foam monolith combined with the high surface area of the reactant, enables essentially 100% of the nickel reactant to come into contact with the fuel stream being desulfurized. The scrubber bed can also be formed from high surface area nickel coated alumina pellets, from a high surface area nickel coated ceramic extrusion, from high surface area nickel pellets, and from high surface area nickel extrudates.

摘要翻译： 硫洗涤方法和结构可操作以基本上除去未稀释的含氧烃燃料原料供应中存在的硫，其可用于为移动环境（例如汽车）中的内燃机或燃料电池发电厂供电， 公共汽车，卡车，船等，或在静止的环境中。 燃料原料可以是汽油，柴油燃料或含有比较高含量的有机硫化合物如硫醇，硫化物，二硫化物，噻吩等的类似燃料。 未稀释的碳氢化合物燃料供应通过脱硫器床，该脱硫器床设置有高表面积的镍反应物，并且其中洗涤床中的基本上所有的镍反应物与燃料流中的硫反应，以便从燃料中除去硫 将其转化为洗涤床上的硫化镍。 燃料流的脱硫有机残余物继续通过燃料电池发电厂的燃料处理系统的其余部分，或通过内燃机。 脱硫剂床优选由高表面积的陶瓷泡沫整体形成，其孔被高表面积的镍反应物涂覆。 使用与反应物的高表面积结合的泡沫整体使基本上100％的镍反应物与正在脱硫的燃料流接触。 洗涤床还可以由高表面积镍涂层氧化铝颗粒，高表面积镍涂层陶瓷挤出物，高表面积镍颗粒和高表面积镍挤出物形成。

公开(公告)号：US20050197338A1

公开(公告)日：2005-09-08

申请号：US10970769

申请日：2004-10-21

申请人： He Huang ,  Michael Stealey ,  Gunnar Hanson ,  Patrick Lennon ,  Bruce Hamper ,  Jin Xie ,  David Oburn ,  Serge Wolfson ,  Theresa Fletcher ,  Richard Heier ,  Matthew Reding ,  Michael Clare

发明人： He Huang ,  Michael Stealey ,  Gunnar Hanson ,  Patrick Lennon ,  Bruce Hamper ,  Jin Xie ,  David Oburn ,  Serge Wolfson ,  Theresa Fletcher ,  Richard Heier ,  Matthew Reding ,  Michael Clare

IPC分类号： A61K31/415 ,  A61K31/416 ,  A61K31/422 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53 ,  C07D231/38 ,  C07D231/40 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10

CPC分类号： C07D403/10 ,  C04B35/632 ,  C07D231/38 ,  C07D401/12 ,  C07D403/04 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10

摘要： Compounds of Formula I: wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed.

摘要翻译： 式I的化合物：其中X 1，X 2，L 1，A，R，L 2， R 1，R 12，R 12，R 13，R 14和R 14，和 R 14a如本文所定义。

公开(公告)号：US20050031506A1

公开(公告)日：2005-02-10

申请号：US10635269

申请日：2003-08-07

申请人： He Huang ,  Zissis Dardas ,  Joseph Sangiovanni

发明人： He Huang ,  Zissis Dardas ,  Joseph Sangiovanni

IPC分类号： B01D20060101 ,  B01J8/04 ,  B01J19/24 ,  C10G11/18

CPC分类号： B01J19/2495 ,  B01J2219/00081 ,  C10G11/18

摘要： A sulfur scrubber structure is operable to remove substantially all of the sulfur present in an undiluted oxygenated hydrocarbon fuel stock supply for a fuel cell power plant assembly which is used to power an engine in a mobile environment, such as an automobile, bus, truck, boat, or the like, or in a stationary environment. The fuel stock can be gasoline, diesel fuel, or other like fuels which contain relatively high levels of organic sulfur compounds such as mercaptans, sulfides, disulfides, and the like. The undiluted hydrocarbon fuel supply is passed through a nickel reactant desulfurizer bed (2) wherein essentially all of the nickel reactant in the scrubber bed reacts with sulfur in the fuel stream, whereby the nickel reactant is converted to nickel sulfide, while the desulfurized organic remnants of the fuel stream continue through the remainder of the fuel processing system. The desulfurizer bed can be formed from a highly porous ceramic or metallic foam monolith, the pores (6) of which are coated with a nickel reactant. The foam monolith can be formed from elemental nickel per se. The use of the high surface area porous foam monolith enables essentially 100% of the nickel reactant to come into contact with the fuel stream being desulfurized.

摘要翻译： 硫洗涤器结构可操作以去除用于燃料电池组件的未稀释的含氧烃燃料原料供应中基本上所有的硫，其用于为诸如汽车，公共汽车，卡车的移动环境中的发动机供电， 船等，或在静止的环境中。 燃料原料可以是含有比较高含量的有机硫化合物如硫醇，硫化物，二硫化物等的汽油，柴油燃料或其他类似的燃料。 未稀释的碳氢燃料供应通过镍反应物脱硫器床（2），其中洗涤床中基本上所有的镍反应物与燃料流中的硫反应，由此将镍反应物转化为硫化镍，而脱硫的有机残余物 的燃料流继续通过燃料处理系统的其余部分。 脱硫器床可以由高度多孔的陶瓷或金属泡沫整体形成，孔（6）涂覆有镍反应物。 泡沫整体可以由元素镍本身形成。 使用高表面积的多孔泡沫整体体使得基本上100％的镍反应物与正在脱硫的燃料流接触。

公开(公告)号：US06514977B1

公开(公告)日：2003-02-04

申请号：US09196623

申请日：1998-11-20

申请人： Ashok Anantanarayan ,  Michael Clare ,  Paul W. Collins ,  Joyce Zuowu Crich ,  Rajesh Devraj ,  Daniel L. Flynn ,  Lifeng Geng ,  Matthew J. Graneto ,  Cathleen E. Hanau ,  Gunnar J. Hanson ,  Susan J. Hartmann ,  Michael Hepperle ,  He Huang ,  Francis J. Koszyk ,  Shuyuan Liao ,  Suzanne Metz ,  Richard A. Partis ,  Thao D. Perry ,  Shashidhar N. Rao ,  Shaun Raj Selness ,  Michael S. South ,  Michael A. Stealey ,  John Jeffrey Talley ,  Michael L. Vazquez ,  Richard M. Weier ,  Xiangdong Xu ,  Ish K. Khanna ,  Yi Yu

发明人： Ashok Anantanarayan ,  Michael Clare ,  Paul W. Collins ,  Joyce Zuowu Crich ,  Rajesh Devraj ,  Daniel L. Flynn ,  Lifeng Geng ,  Matthew J. Graneto ,  Cathleen E. Hanau ,  Gunnar J. Hanson ,  Susan J. Hartmann ,  Michael Hepperle ,  He Huang ,  Francis J. Koszyk ,  Shuyuan Liao ,  Suzanne Metz ,  Richard A. Partis ,  Thao D. Perry ,  Shashidhar N. Rao ,  Shaun Raj Selness ,  Michael S. South ,  Michael A. Stealey ,  John Jeffrey Talley ,  Michael L. Vazquez ,  Richard M. Weier ,  Xiangdong Xu ,  Ish K. Khanna ,  Yi Yu

IPC分类号： A61K31454

CPC分类号： C07D409/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.

公开(公告)号：US06512003B2

公开(公告)日：2003-01-28

申请号：US09974070

申请日：2001-10-09

申请人： Fatih M. Uckun ,  Chen Mao ,  He Huang

发明人： Fatih M. Uckun ,  Chen Mao ,  He Huang

IPC分类号： A61K3138

CPC分类号： C07D493/10 ,  C07C323/41 ,  C07D307/12 ,  C07D307/42 ,  C07K14/47

摘要： Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.