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    CATALYST-FREE SURFACE FUNCTIONALIZATION AND POLYMER GRAFTING
    41.
    发明申请
    CATALYST-FREE SURFACE FUNCTIONALIZATION AND POLYMER GRAFTING 有权

    公开(公告)号：US20210189082A1

    公开(公告)日：2021-06-24

    申请号：US17194019

    申请日：2021-03-05

    Applicant: Illumina, Inc.

    Inventor： Lorenzo Berti ,  Andrew A. Brown ,  Wayne N. George

    IPC: C08J7/12 ,  C12Q1/6876 ,  C08F8/00 ,  C12Q1/6874 ,  B01J19/00 ,  C09D133/26 ,  C12Q1/6837

    Abstract: Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. Method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications are also disclosed.

    ARRAYS INCLUDING A RESIN FILM AND A PATTERNED POLYMER LAYER
    45.
    发明申请
    ARRAYS INCLUDING A RESIN FILM AND A PATTERNED POLYMER LAYER 审中-公开

    公开(公告)号：US20180179575A1

    公开(公告)日：2018-06-28

    申请号：US15848640

    申请日：2017-12-20

    Applicant: ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

    Inventor： Wayne N. George ,  Alexandre Richez ,  M. Shane Bowen ,  Andrew A. Brown ,  Dajun M. Yuan ,  Audrey Rose Zak ,  Sean M. Ramirez ,  Raymond Campos

    IPC: C12Q1/68 ,  C09D183/06 ,  C09D133/26

    Abstract: An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.

    Polymer coatings
    48.
    发明授权
    Polymer coatings 有权
    聚合物涂料

    公开(公告)号：US09012022B2

    公开(公告)日：2015-04-21

    申请号：US13784368

    申请日：2013-03-04

    Applicant: Illumina, Inc.

    Inventor： Wayne N. George ,  Andrew A. Brown ,  Daniel Bratton ,  Hongji Ren ,  Ryan C. Smith

    IPC: B05D3/06 ,  C09D133/26 ,  C09D135/00

    CPC classification number: C12Q1/6874 ,  B05D3/06 ,  B05D3/065 ,  C09D133/26 ,  C09D135/00 ,  C12Q1/6806 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/2998 ,  Y10T428/31536 ,  Y10T428/31935

    Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

    Abstract translation: 本公开内容涉及共价连接到基材表面上的聚合物涂层以及聚（N-（5-叠氮基乙酰胺基戊基）丙烯酰胺 - 共 - 丙烯酰胺）聚合物涂层的制备（PAZAM），其形成和操作 底物，如分子阵列和流动池。 本公开还涉及通过使用涂覆有共价连接的聚合物（例如PAZAM）的珠来制备底物表面的方法，以及测定与本文所述的底物表面连接的多核苷酸的核苷酸序列的方法。

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