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公开(公告)号：US12013330B2
公开(公告)日：2024-06-18
申请号：US16515849
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： G03F7/00 , C08L63/00 , C08L83/12 , G01N15/1434
CPC分类号： G01N15/1436 , C08L63/00 , C08L83/12 , G03F7/0002
摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US20240337582A1
公开(公告)日：2024-10-10
申请号：US18744225
申请日：2024-06-14
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： G01N15/1434 , C08L63/00 , C08L83/12 , G03F7/00
CPC分类号： G01N15/1436 , C08L63/00 , C08L83/12 , G03F7/0002
摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US11667969B2
公开(公告)日：2023-06-06
申请号：US15969562
申请日：2018-05-02
发明人： Sean M. Ramirez , Brian D. Mather , Edwin Li , Sojeong Moon , Innsu Daniel Kim , Alexandre Richez , Ludovic Vincent , Xavier von Hatten , Hai Quang Tran , Maxwell Zimmerley , Julia Morrison , Gianluca Andrea Artioli , Krystal Sly , Hayden Black , Lewis J. Kraft , Hong Xie , Wei Wei , Ryan Sanford
IPC分类号： B01L3/00 , C12Q1/6874 , C12Q1/6806
CPC分类号： C12Q1/6874 , B01L3/502707 , C12Q1/6806 , B01L2300/0819 , B01L2300/0877 , B01L2300/0887 , B01L2300/16 , B01L2300/165
摘要： An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.
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公开(公告)号：US20230416435A1
公开(公告)日：2023-12-28
申请号：US18330298
申请日：2023-06-06
发明人： Gianluca Andrea Artioli , Timothy J.N. Beech , Mathieu Lessard-Viger , Rebecca Turk-MacLeod , Brian D. Mather , Weixian Xi , Xavier von Hatten
IPC分类号： C08F220/56 , C08J3/075 , C12Q1/6869
CPC分类号： C08F220/56 , C08J3/075 , C12Q1/6869 , C08J2333/26
摘要： A co-polymer includes a plurality of a first monomer including a terminal functional group that is to attach to at least two different primers; a plurality of a second monomer including a second functional group that is different from the terminal functional group, and that is selected from the group consisting of a phenyl group, methoxy propyl, glycosyl, vinyl pyrrolidone, and an imidazole group; and a plurality of a third monomer that is different from the first and second monomers. This co-polymer may be used in a flow cell, and may enhance the clustering efficiency and kinetics.
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公开(公告)号：US20230272469A1
公开(公告)日：2023-08-31
申请号：US18195321
申请日：2023-05-09
发明人： Sean M. Ramirez , Brian D. Mather , Edwin Li , Sojeong Moon , Innsu Daniel Kim , Alexandre Richez , Ludovic Vincent , Xavier von Hatten , Hai Quang Tran , Maxwell Zimmerley , Julia Morrison , Gianluca Andrea Artioli , Krystal Sly , Hayden Black , Lewis J. Kraft , Hong Xie , Wei Wei , Ryan Sanford
IPC分类号： C12Q1/6874 , C12Q1/6806 , B01L3/00
CPC分类号： C12Q1/6874 , C12Q1/6806 , B01L3/502707 , B01L2300/165 , B01L2300/0819 , B01L2300/0887 , B01L2300/16 , B01L2300/0877
摘要： An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.
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公开(公告)号：US20220154177A1
公开(公告)日：2022-05-19
申请号：US17525553
申请日：2021-11-12
IPC分类号： C12N15/10 , C08F265/10 , C08J3/075
摘要： An example of a functionalized plasmonic nanostructure includes a plasmonic nanostructure core; a polymeric hydrogel attached to the plasmonic nanostructure core, the polymeric hydrogel having a thickness ranging from about 10 nm to about 200 nm; and a plurality of primers attached to side chains or arms of the polymeric hydrogel, wherein at least some of the plurality of primers are attached to the polymeric hydrogel at different distances from the plasmonic nanostructure core.
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公开(公告)号：US20200025670A1
公开(公告)日：2020-01-23
申请号：US16515849
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US11884976B2
公开(公告)日：2024-01-30
申请号：US16515790
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： C12Q1/6874 , C08G77/442 , C09D153/00 , C12Q1/6876 , C09D163/00 , C08L63/00 , C08L33/04
CPC分类号： C12Q1/6874 , C08G77/442 , C08L33/04 , C08L63/00 , C09D153/00 , C09D163/00 , C12Q1/6876
摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US20220154273A1
公开(公告)日：2022-05-19
申请号：US17525530
申请日：2021-11-12
发明人： Gianluca Andrea Artioli , Mathieu Lessard-Viger , Brian D. Mather , Seth M. McDonald , Kaitlin M. Pugliese , Xavier von Hatten
IPC分类号： C12Q1/6874 , B01L3/00
摘要： An example of an incorporation mix includes a liquid carrier, a complex, and a labeled nucleotide. The complex includes a polymerase and a plasmonic nanostructure linked to the polymerase. The labeled nucleotide includes a nucleotide, a 3′ OH blocking group attached to a sugar of the nucleotide, and a dye label attached to a base of the nucleotide.
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公开(公告)号：US20200024661A1
公开(公告)日：2020-01-23
申请号：US16515790
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： C12Q1/6874 , C08G77/442 , C08L63/00 , C12Q1/6876 , C09D163/00 , C09D153/00
摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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