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公开(公告)号：US11932900B2
公开(公告)日：2024-03-19
申请号：US17973327
申请日：2022-10-25
发明人： Wayne N. George , Alexandre Richez , M. Shane Bowen , Andrew A. Brown , Dajun Yuan , Audrey Rose Zak , Sean M. Ramirez , Raymond Campos
IPC分类号： C08J7/04 , C09D133/26 , C09D183/06 , C12Q1/68 , C08G77/14
CPC分类号： C12Q1/68 , C09D133/26 , C09D183/06 , C08G77/14
摘要： An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (POSS) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy POSS resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy POSS resin film, and a polymer coating is attached to the exposed discrete areas. Another example of an array includes a support, a modified epoxy POSS resin film on a surface of the support, and a patterned hydrophobic polymer layer on the modified epoxy POSS resin film. The modified epoxy POSS resin film includes a polymer growth initiation site, and the patterned hydrophobic polymer layer defines exposed discrete areas of the modified epoxy POSS resin film. A polymer brush is attached to the polymer growth initiation site in the exposed discrete areas.
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公开(公告)号：US11384392B2
公开(公告)日：2022-07-12
申请号：US17139834
申请日：2020-12-31
发明人： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC分类号： C12Q1/6869 , C08F220/56 , C08G77/04 , G03F7/075 , G03F7/16 , G03F7/00 , G03F7/004
摘要： An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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公开(公告)号：US20210024991A1
公开(公告)日：2021-01-28
申请号：US16626452
申请日：2019-06-07
发明人： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown , Dajun Yuan
IPC分类号： C12Q1/6869 , G03F7/075 , C08G77/04 , C08F220/56
摘要： An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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公开(公告)号：US20200025670A1
公开(公告)日：2020-01-23
申请号：US16515849
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US20180178416A1
公开(公告)日：2018-06-28
申请号：US15847150
申请日：2017-12-19
发明人： Alexandre Richez , Andrew A. Brown , Julia Morrison , Wayne N. George , Timothy J. Merkel , Audrey Rose Zak
摘要： An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. A method includes forming a master template by: depositing a formulation on a silicon master including a plurality of nanofeatures defined therein, the formulation including a solvent and a molecule having a cyclosiloxane with at least one silane functional group; and curing the formulation, thereby forming an anti-stick layer on the silicon master, the anti-stick layer including the molecule. The method further includes depositing a silicon-based working stamp material on the anti-stick layer of the master template; curing the silicon-based working stamp material to form a working stamp including a negative replica of the plurality of nanofeatures; and releasing the working stamp from the master template.
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公开(公告)号：US11884976B2
公开(公告)日：2024-01-30
申请号：US16515790
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： C12Q1/6874 , C08G77/442 , C09D153/00 , C12Q1/6876 , C09D163/00 , C08L63/00 , C08L33/04
CPC分类号： C12Q1/6874 , C08G77/442 , C08L33/04 , C08L63/00 , C09D153/00 , C09D163/00 , C12Q1/6876
摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US20220145379A1
公开(公告)日：2022-05-12
申请号：US17599994
申请日：2020-11-25
发明人： Wayne N. George , Brian D. Mather , Andrew A. Brown , Pietro Gatti Lafranconi , Maria Candelaria Rogert Bacigalupo , Antoine Francais , Xiaohai Liu
IPC分类号： C12Q1/6848 , C12Q1/6869
摘要： An example of a kit includes a flow cell and a cleavage mix. An example flow cell includes a substrate; a catalytic polymeric hydrogel on the substrate, the catalytic polymeric hydrogel including a deblocking catalyst; and an amplification primer attached to the catalytic polymeric hydrogel. The deblocking catalyst accelerates cleavage of a blocking group of a 3′ OH blocked nucleotide introduced to the flow cell and incorporated into a template strand attached to the amplification primer. An example of the cleavage mix includes a component to initiate cleavage of the blocking group.
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公开(公告)号：US20200024661A1
公开(公告)日：2020-01-23
申请号：US16515790
申请日：2019-07-18
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： C12Q1/6874 , C08G77/442 , C08L63/00 , C12Q1/6876 , C09D163/00 , C09D153/00
摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US20240337582A1
公开(公告)日：2024-10-10
申请号：US18744225
申请日：2024-06-14
发明人： Timothy J. Merkel , Wayne N. George , Andrew A. Brown , Audrey Zak , Gianluca Andrea Artioli , Julia Morrison , Nikolai Romanov , Lorenzo Berti , Graham Boud
IPC分类号： G01N15/1434 , C08L63/00 , C08L83/12 , G03F7/00
CPC分类号： G01N15/1436 , C08L63/00 , C08L83/12 , G03F7/0002
摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.
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公开(公告)号：US11988957B2
公开(公告)日：2024-05-21
申请号：US18317865
申请日：2023-05-15
发明人： Jeffrey S. Fisher , Brian D. Mather , Maria Candelaria Rogert Bacigalupo , Justin Fullerton , Ludovic Vincent , Lewis J. Kraft , Sahngki Hong , Boyan Boyanov , M. Shane Bowen , Sang Park , Wayne N. George , Andrew A. Brown
IPC分类号： G03F7/00 , C08F220/56 , C08G77/04 , C12Q1/6869 , G03F7/075 , G03F7/16 , G03F7/004
CPC分类号： G03F7/0002 , C08F220/56 , C08G77/04 , C12Q1/6869 , G03F7/0757 , G03F7/165 , G03F7/0046
摘要： An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
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