公开(公告)号：US10094805B2

公开(公告)日：2018-10-09

申请号：US15583501

申请日：2017-05-01

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N1/10 ,  G01N27/447 ,  G01N33/487 ,  C12Q1/6869

Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

公开(公告)号：US09995710B2

公开(公告)日：2018-06-12

申请号：US15141220

申请日：2016-04-28

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: G01N27/327 ,  G01N27/447 ,  G01N33/487 ,  B82Y30/00 ,  B82Y15/00 ,  B82Y35/00

CPC classification number: G01N27/44791 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y35/00 ,  G01N27/4473 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/742 ,  Y10S977/845 ,  Y10S977/88

Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.

公开(公告)号：US09658184B2

公开(公告)日：2017-05-23

申请号：US14271926

申请日：2014-05-07

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N1/10 ,  G01N27/403 ,  B82Y30/00 ,  G01N33/487

CPC classification number: G01N27/44791 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721

Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

公开(公告)号：US09528153B2

公开(公告)日：2016-12-27

申请号：US14615910

申请日：2015-02-06

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: C12Q1/68 ,  G01N27/447 ,  G01N27/453 ,  B82Y30/00 ,  B82Y5/00

CPC classification number: C12Q1/6869 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N27/453 ,  Y10S977/742 ,  Y10S977/781 ,  Y10S977/924

Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.

Abstract translation: 提供用于棘轮双链分子的机制。 双链分子通过第一电压脉冲被驱动到膜的Y通道中。 Y型通道包括杆和支杆，并且分支在连接处连接到杆。 基于第一电压脉冲的Y通道的连接处的双链分子比破坏双链分子的碱基对所需的力弱。 通过在第二电压脉冲下将双链分子驱动到Y通道的结中，将双链分子分成第一单链和第二单链。

公开(公告)号：US09428804B2

公开(公告)日：2016-08-30

申请号：US13971486

申请日：2013-08-20

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: C12Q1/68 ,  G01N27/447 ,  G01N27/453 ,  B82Y30/00 ,  B82Y5/00

CPC classification number: C12Q1/6869 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N27/453 ,  Y10S977/742 ,  Y10S977/781 ,  Y10S977/924

Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.

Abstract translation: 提供用于棘轮双链分子的机制。 双链分子通过第一电压脉冲被驱动到膜的Y通道中。 Y型通道包括杆和支杆，并且分支在连接处连接到杆。 基于第一电压脉冲的Y通道的连接处的双链分子比破坏双链分子的碱基对所需的力弱。 通过在第二电压脉冲下将双链分子驱动到Y通道的结中，将双链分子分成第一单链和第二单链。

公开(公告)号：US09428803B2

公开(公告)日：2016-08-30

申请号：US13724041

申请日：2012-12-21

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: C12Q1/68 ,  G01N27/447 ,  G01N27/453 ,  B82Y30/00 ,  B82Y5/00

CPC classification number: C12Q1/6869 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N27/453 ,  Y10S977/742 ,  Y10S977/781 ,  Y10S977/924

Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.

公开(公告)号：US09372171B2

公开(公告)日：2016-06-21

申请号：US13873815

申请日：2013-04-30

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Binquan Luan ,  Ruhong Zhou

IPC: G01N27/447 ,  G01N33/487 ,  B82Y30/00

CPC classification number: G01N27/44791 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y35/00 ,  G01N27/4473 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/742 ,  Y10S977/845 ,  Y10S977/88

Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.

Abstract translation: 用于检测分子特征的纳米传感器包括具有开口的膜，该开口被配置为允许带电的碳纳米管通过，但是阻挡附着在碳纳米管上的分子。 开口充满电解液。 电场发生器被配置为相对于开口产生电场，以驱动带电的碳纳米管通过开口。 传感器电路耦合到电场发生器以感测由于带电的碳纳米管进入开口而导致的电流变化，并且偏置电场发生器以确定与碳纳米管和分子之间的分离力相关的临界电压。

公开(公告)号：US09285337B2

公开(公告)日：2016-03-15

申请号：US14695390

申请日：2015-04-24

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Sung-wook Nam

IPC: C12Q1/68 ,  G01N27/414 ,  G01N27/447

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  G01N27/44791

Abstract: A technique includes providing a nanodevice. A gate electrode structure has nanochannels with a first end connected to a first common trench and a second end connected to a second common trench. A gate electrode extends laterally as a continuous line on the gate electrode structure and is formed in each of the nanochannels. The gate electrode forms a separate nano-ring electrode around a partial circumference inside each of the nanochannels. The gate electrode is parallel to the first and second common trenches and is perpendicular to the nanochannels.

公开(公告)号：US20150323490A1

公开(公告)日：2015-11-12

申请号：US14271926

申请日：2014-05-07

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N27/403

CPC classification number: G01N27/44791 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721

Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

Abstract translation: 提供了使用纳米结构的纳米结构的纳米和微通道的聚合物测试结构中的捕获区增加技术，例如纳米结构。 一方面，提供了一种用于测试聚合物的测试结构，其包括第一流体储存器和形成在电绝缘基底中的第二流体储存器; 至少一个通道，其形成在所述绝缘基板中，所述至少一个通道将所述第一流体储存器和所述第二流体储存器互连; 以及在第一流体储存器或第二流体储存器内的纳米结构的布置，其中纳米结构被布置成在第一流体储存器或第二流体储存器内部形成多个同心圆，其中每个同心圆以入口 点的通道。 还提供了使用测试结构分析聚合物的方法。

公开(公告)号：US20150275288A1

公开(公告)日：2015-10-01

申请号：US14225677

申请日：2014-03-26

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Sung-wook Nam

IPC: C12Q1/68 ,  G01N27/40 ,  G01N27/447

CPC classification number: C12Q1/6869 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2563/157

Abstract: A technique is provided for controlling biomolecules in a nanodevice. A membrane has two reservoirs at opposing ends of the membrane. A nanochannel is formed in the membrane connecting the two reservoirs. A gate electrode is formed on the membrane such that the gate electrode extends laterally in a region of the nanochannel. A biomolecule is trapped in the nanochannel by applying a first voltage to the gate electrode. In response to trapping the biomolecule, the biomolecule is stretched in the nanochannel by applying a second voltage to the gate electrode. The biomolecule is stretched based on changing from the first voltage to the second voltage applied to the gate electrode.

Abstract translation: 提供了一种用于控制纳米设备中生物分子的技术。 膜在膜的相对端具有两个储存器。 在连接两个储存器的膜中形成纳米通道。 栅电极形成在膜上，使得栅电极在纳米通道的区域中横向延伸。 生物分子通过向栅电极施加第一电压而被捕获在纳米通道中。 响应于捕获生物分子，通过向栅电极施加第二电压，在纳米通道中拉伸生物分子。 基于从施加到栅电极的第一电压到第二电压的变化，生物分子被拉伸。