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公开(公告)号：US20090074777A1
公开(公告)日：2009-03-19
申请号：US11909308
申请日：2005-09-21
申请人： Jack R. Wands , Miran Kim
发明人： Jack R. Wands , Miran Kim
IPC分类号： A61K39/395 , G01N33/53 , C07K16/18 , G01N33/566 , A61K38/00 , A61P31/00 , A61K31/7105 , C12Q1/02 , C12Q1/68
CPC分类号： G01N33/5067 , G01N33/5011
摘要： The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
摘要翻译： 本说明书尤其提供了在癌症诊断和治疗中使用Wnt和FZD蛋白，基因，FZD和Wnt特异性抗体和探针并用于筛选测试化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。
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公开(公告)号：US07300927B2
公开(公告)日：2007-11-27
申请号：US10669217
申请日：2003-09-23
IPC分类号： A61K31/555 , A61K31/415
CPC分类号： A61K38/30 , A61K31/00 , A61K31/28 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/48 , A61K31/4985 , A61K33/24
摘要： Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an agent which reduces serum insulin levels.
摘要翻译： 公开了一种通过限制饮食中可代谢的碳水化合物的水平和/或向患者施用有效量的降低血清胰岛素水平的药物来治疗或预防阿尔茨海默氏病的方法。
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公开(公告)号：US07094556B2
公开(公告)日：2006-08-22
申请号：US09903023
申请日：2001-07-11
IPC分类号： G01N33/53
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US06815415B2
公开(公告)日：2004-11-09
申请号：US09903063
申请日：2001-07-11
IPC分类号： A61K3800
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US06783758B2
公开(公告)日：2004-08-31
申请号：US09903248
申请日：2001-07-11
IPC分类号： A61K39395
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
摘要： The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
摘要翻译： 本发明的特征在于通过使来自哺乳动物的体液与结合人天冬氨酰基（天冬酰胺酰基）β-羟化酶（HAAH））多肽的抗体和通过抑制HAAH治疗恶性肿瘤的方法接触来诊断哺乳动物的恶性肿瘤的方法。
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公开(公告)号：US06753328B2
公开(公告)日：2004-06-22
申请号：US10262778
申请日：2002-10-01
申请人： Jack R. Wands , Rolf I. Carlson , Paul Maggio
发明人： Jack R. Wands , Rolf I. Carlson , Paul Maggio
IPC分类号： A61K3154
CPC分类号： A61K31/549 , Y10S514/893
摘要： The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
摘要翻译： 本发明涉及预防和治疗传播性癌症的方法。 原发性肿瘤向肝组织的转移是通过直接接触肝脏组织与替罗唑来进行的。
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公开(公告)号：US06258937B1
公开(公告)日：2001-07-10
申请号：US09361707
申请日：1999-07-27
申请人： Shuping Tong , Jisu Li , Jack R. Wands
发明人： Shuping Tong , Jisu Li , Jack R. Wands
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The invention features an hepadnavirus cellular receptor and a nucleic acid sequence that encodes the receptor. The receptor is a 170 kD surface glycoprotein, and is referred to as the p170 receptor.
摘要翻译： 本发明的特征在于肝炎疫苗细胞受体和编码受体的核酸序列。 受体是170kD的表面糖蛋白，被称为p170受体。
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公开(公告)号：US06071705A
公开(公告)日：2000-06-06
申请号：US469629
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K39/395 , A61K51/00 , C07H21/04 , C07K1/22 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C12N5/10 , C12N15/09 , C12P21/00 , C12Q1/68 , G01N33/577 , G01N33/68
CPC分类号： C12Q1/6883 , C07K14/474 , C07K16/18 , G01N33/6878 , G01N33/6896 , C12Q2600/158 , G01N2800/2821 , Y10S436/804 , Y10S436/811
摘要： This invention relates to a method of detecting and diagnosing neurological disease or dysfunction using antibodies against a neurological form of Pancreatic Thread Protein (nPTP). Specifically, this invention is directed to a method of diagnosing Alzheimer's Disease, Down's Syndrome, and other neurological diseases or dysfunctions by using monoclonal antibodies, combination of those monoclonal antibodies or nucleic acid probes, to detect nPTP. The invention also relates to a recombinant DNA molecule encoding PTP and to the substantially pure form of nPTP. The invention additionally relates to a method of diagnosing pancreatic disease using antibodies against Pancreatic Thread Protein.
摘要翻译： 本发明涉及使用针对胰腺线蛋白（nPTP）神经病学形式的抗体检测和诊断神经疾病或功能障碍的方法。 具体地，本发明涉及通过使用单克隆抗体，那些单克隆抗体或核酸探针的组合来检测nPTP来诊断阿尔茨海默病，唐氏综合征和其他神经疾病或功能障碍的方法。 本发明还涉及编码PTP的重组DNA分子和基本上纯的形式的nPTP。 本发明还涉及使用针对胰线螺蛋白的抗体诊断胰腺疾病的方法。
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公开(公告)号：US6060595A
公开(公告)日：2000-05-09
申请号：US968747
申请日：1997-09-03
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K48/00 , A61P31/12 , C07H21/04 , C07K14/02 , C12N5/10 , C12N7/00 , C12P21/02 , C12R1/91
CPC分类号： C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2740/13043
摘要： The invention relates to methods and compositions for inhibition of viral replication in animal cells. In particular, inhibition of viral replication in a target cell is achieved by introducing into the cell (1) a protein which can be incorporated along with wild type nucleocapsid subunits into a viral nucleocapsid assembling within the cell, and thereby renders the nucleocapsid deficient in encapsidating viral nucleic acid; or (2) a recombinant nucleic acid construct that directs overexpression of the protein.
摘要翻译： 本发明涉及抑制动物细胞中病毒复制的方法和组合物。 特别地，通过向细胞（1）中引入可以与野生型核衣壳亚基一起掺入到细胞内的病毒核衣壳组合中的蛋白质来实现对靶细胞中病毒复制的抑制，从而使核衣壳缺乏包囊 病毒核酸; 或（2）指导蛋白质过表达的重组核酸构建体。
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50.发明授权
公开(公告)号：US5948634A
公开(公告)日：1999-09-07
申请号：US340426
申请日：1994-11-14
申请人： Suzanne de la Monte , Jack R. Wands
发明人： Suzanne de la Monte , Jack R. Wands
CPC分类号： C07K14/474 , A61K49/0008 , C07K14/47 , C07K14/4711 , C07K16/18 , C12Q1/6883 , G01N33/6878 , G01N33/6896 , A61K38/00 , C12Q2600/158 , G01N2800/2821 , Y10S530/839
摘要： The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes coding for the neuronal thread proteins. This invention is also directed to substantially pure neural thread protein, immunodiagnostic and molecular diagnostic methods to detect the presence of neural thread proteins, and the use of nucleic acid sequences which code for neural thread proteins in gene therapy.
摘要翻译： 本发明涉及表达与阿尔茨海默氏病，神经外胚层肿瘤，恶性星形细胞瘤和成胶质细胞瘤相关的新蛋白质的重组宿主。 本发明特别针对含有编码神经元线蛋白的基因的重组宿主和载体。 本发明还涉及基本上纯粹的神经线蛋白，免疫诊断和分子诊断方法来检测神经线蛋白的存在，以及在基因治疗中使用编码神经线蛋白的核酸序列。
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