公开(公告)号：US5353273A

公开(公告)日：1994-10-04

申请号：US926061

申请日：1992-08-04

Applicant: James M. Zavislan ,  Bulent N. Kurdi

Inventor： James M. Zavislan ,  Bulent N. Kurdi

IPC: G11B7/12 ,  G11B7/14 ,  G11B7/00

CPC classification number: G11B7/14 ,  G11B7/124

Abstract: A multichannel optical head and data storage system employs an integrated-optical read channel. The read channel may be fabricated on a planar waveguide structure that separates the data signals of the multiple lasers. The read channel includes focus error sensors and track error sensors. The optical head may be used for amplitude recording systems such as phase-change erasable and write-once media, ablation media, dye-polymer media, and OD-ROM systems.

Abstract translation: 多通道光头和数据存储系统采用集成光读取通道。 读通道可以在分离多个激光器的数据信号的平面波导结构上制造。 读通道包括聚焦误差传感器和轨道误差传感器。 光头可用于振幅记录系统，例如相变可擦除和一次写入介质，消融介质，染料聚合物介质和OD-ROM系统。

公开(公告)号：US5253236A

公开(公告)日：1993-10-12

申请号：US770560

申请日：1991-10-03

Applicant: Milton R. Latta ,  Timothy C. Strand ,  James M. Zavislan

Inventor： Milton R. Latta ,  Timothy C. Strand ,  James M. Zavislan

IPC: G11B7/09 ,  G11B7/135 ,  G11B11/105 ,  G11B21/00

CPC classification number: G11B7/1381 ,  G11B11/10576 ,  G11B7/0908 ,  G11B7/0909 ,  G11B7/0912 ,  G11B7/0916

Abstract: A mask is used to remove substantially all of the first order diffraction components of a reflected light beam which are generated as the beam crosses grooved data tracks in an optical media. The mask may comprise a transparent substrate with an opaque layer having a pair of circular apertures or a bow-tie shaped aperture. The apertures are located outside the regions of interference between the diffracted components and the undiffracted component. The layer may be made of a reflective material for reflecting diffracted components of the reflected beam to a tracking error sensor. The layer may be made of a holographic material for deflecting the diffracted components to a tracking error sensor.

Abstract translation: 掩模用于去除当光束穿过光学介质中的带槽数据轨道时产生的反射光束的基本上所有的一级衍射分量。 掩模可以包括具有不透明层的透明基底，该不透明层具有一对圆形孔或弓形孔。 这些孔位于衍射部件和未衍射部件之间的干涉区域的外侧。 该层可以由用于将反射光束的衍射分量反射到跟踪误差传感器的反射材料制成。 该层可以由全息材料制成，用于将衍射成分偏转到跟踪误差传感器。

公开(公告)号：US08149506B2

公开(公告)日：2012-04-03

申请号：US10162317

申请日：2002-06-04

Applicant: Jay M. Eastman ,  William J. Fox ,  Roger J. Greenwald ,  Kevin P. Roesser ,  James M. Zavislan

Inventor： Jay M. Eastman ,  William J. Fox ,  Roger J. Greenwald ,  Kevin P. Roesser ,  James M. Zavislan

IPC: G02B21/26

CPC classification number: G02B21/368 ,  B01L3/508 ,  B01L2200/0642 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0822 ,  B01L2300/123 ,  G01N2001/315 ,  G02B21/0012 ,  G02B21/26 ,  G02B21/33 ,  G02B21/34

Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having an optically transparent window upon which a tissue specimen is situated, a membrane locatable over a substantial portion of the base member including the window, and an upper member which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may then be positioned planar against the window and retained in that position by bonds formed between the membrane and window around the tissue specimen. The cassette may be part of a confocal imaging system to produce microscopic images of sections of the tissue specimen useful for Mohs surgery.

Abstract translation: 用于通过共聚焦显微镜或其他光学成像显微镜以方便光学切片的方向从患者保持外科手术曝光的组织的样本的盒。 所述盒包括基部构件，所述基座构件具有光学透明窗口，组织样本位于所述窗口上，可以位于包括所述窗口的所述基座构件的主要部分上的膜;以及上部构件，其可以覆盖所述基座构件以在 膜和窗口密封组织标本。 然后可以将组织样本的边缘定位成相对于窗户平面并且通过在组织样本周围的膜和窗口之间形成的粘结保持在该位置。 盒可以是共焦成像系统的一部分，以产生用于莫氏手术的组织标本的切片的显微镜图像。

公开(公告)号：US07813788B2

公开(公告)日：2010-10-12

申请号：US11013099

申请日：2004-12-15

Applicant: James M. Zavislan ,  Jay M. Eastman

Inventor： James M. Zavislan ,  Jay M. Eastman

IPC: A61B6/00

CPC classification number: A61B5/444 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0068 ,  A61B2562/146

Abstract: A handheld confocal imaging system for in vivo observation of dermal and subdermal tissue allows diagnosis of conditions substantially beneath the surface of the skin. A confocal head has optics which scan the tissue so as to provide images of vertical sections of the tissue. Both two and three dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.

Abstract translation: 用于体内观察皮肤和皮下组织的手持共聚焦成像系统允许诊断基本上在皮肤表面下方的状况。 共焦头具有扫描组织以便提供组织的垂直部分的图像的光学元件。 可以提供二维和三维成像用于诊断和定位基底细胞癌和黑素瘤，并且可以在切除前使肿瘤边界可视化。

公开(公告)号：US07515266B2

公开(公告)日：2009-04-07

申请号：US11499582

申请日：2006-08-04

Applicant: Milind Rajadhyaksha ,  James M. Zavislan

Inventor： Milind Rajadhyaksha ,  James M. Zavislan

IPC: G01J4/00

CPC classification number: G01N21/21 ,  G01N21/47 ,  G01N21/49 ,  G01N2021/4735 ,  G01N2021/4792 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0068 ,  G02B21/14 ,  G02B21/33 ,  G02B21/36

Abstract: A confocal scanning microscope system (10) using cross polarization effects and an enhancement agent (acetic acid) to enhance confocal microscope reflectance images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous cell carcinomas) in the confocal reflectance images of excised tumor slices. The confocal scanning microscope system having a laser (11) for generating an illumination beam (12), a polygon mirror (18) for scanning the beam to a tissue sample (22) and for receiving a returned beam from the tissue sample and detector (28) for detecting the returned beam to form an image. The system further includes a half-wave plate (13) having a rotatable stage (14) and a quarter-wave plate (21) having a rotatable stage (20) disposed in the optical path of the illumination beam and at least a linear polarizer (24) having a rotatable stage (25) disposed in the optical path of the returned beam from the tissue sample.

Abstract translation: 使用交叉极化效应的共聚焦扫描显微镜系统（10）和增强剂（乙酸）以增强切除的共聚焦反射图像中BCC（基底细胞癌）和SCC（鳞状细胞癌）细胞核的共聚焦显微镜反射图像 肿瘤切片。 具有用于产生照明光束（12）的激光（11）的共焦扫描显微镜系统，用于将光束扫描到组织样本（22）并用于从组织样本和检测器（22）接收返回光束的多面镜（18） 28），用于检测返回的光束以形成图像。 该系统还包括具有可旋转台（14）的半波片（13）和设置在照明光束的光路中的可旋转台（20）的四分之一波片（21），并且至少一个线性偏振器 （24）具有设置在来自组织样本的返回光束的光路中的可旋转台（25）。

公开(公告)号：US07194118B1

公开(公告)日：2007-03-20

申请号：US10129719

申请日：2000-11-10

Applicant: Duncan Harris ,  James M. Zavislan

Inventor： Duncan Harris ,  James M. Zavislan

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06K9/00134 ,  G06T2200/32 ,  G06T2207/10056 ,  G06T2207/20016 ,  G06T2207/20092 ,  G06T2207/30024

Abstract: A display (34) provides from digital images of an excised tissue specimen the orientation and location of tissue and regions of interest (cancers). Images of slices through excised specimen are obtained using a confocal microscope (10) to obtain confocal maps to provide a mosaic of images each of which corresponds to a different map element. A macroscopic image of significant map elements and high resolution images of selected elements are provided to locate and mark regions which are cancerous thereby assisting the surgeon to excise such regions.

Abstract translation: 显示器（34）从切除的组织标本的数字图像提供组织和感兴趣区域（癌症）的取向和位置。 通过共聚焦显微镜（10）获得通过切除的样本的切片的图像，以获得共焦图，以提供图像的马赛克，每个图像对应于不同的地图元素。 提供所选元素的显着地图元素和高分辨率图像的宏观图像以定位和标记癌变的区域，从而辅助外科医生切除这些区域。

公开(公告)号：US07139122B1

公开(公告)日：2006-11-21

申请号：US09978957

申请日：2001-10-16

Applicant: Jay M. Eastman ,  Milind Rajadhyaksha ,  James M. Zavislan

Inventor： Jay M. Eastman ,  Milind Rajadhyaksha ,  James M. Zavislan

IPC: G02B21/06 ,  A61K49/00

CPC classification number: G02B21/0068 ,  A61K49/001 ,  G01N33/5743

Abstract: A system using cross polarization effects and an enhancement agent having citric or other similar alpha hydroxy acid to enhance confocal microscope reflectance images and particularly images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous cell carcinomas) in the confocal reflectance images of excised tumor slices obtained during Mohs surgery by illuminating the tissue being imaged (a tumor slice) using polarized light. The reflected illumination is passed to a polarization analyzer, which passes the polarization component which is crossed with respect to the polarization of the illuminating light. The light from the analyzer is passed through the confocal aperture and detected. The section of the tissue either at the surface or within the tissue is scanned and the reflectance image is produced with enhanced visualization of the cellular or nuclear structure thereof thereby enabling determination of the extent of the tumor (cancerous cells) in the section. A method is also provided using the system for diagnosing cancerous cells in skin tissue.

Abstract translation: 使用交叉极化效应的系统和具有柠檬酸或其它类似α羟基酸的增强剂来增强共聚焦显微镜反射图像，特别是BCC（基底细胞癌）和SCC（鳞状细胞癌）的核的图像在共聚焦反射图像中 通过使用偏振光照射被成像的组织（肿瘤切片）在Mohs手术期间获得的切除的肿瘤切片。 反射的照明被传递到偏振分析器，偏振分析器使相对于照明光的偏振交叉的偏振分量通过。 来自分析仪的光通过共焦孔并检测。 扫描在表面或组织内的组织的部分，并且通过细胞或核结构的增强的可视化产生反射图像，从而能够确定该部分中肿瘤（癌细胞）的程度。 还提供了一种用于诊断皮肤组织中的癌细胞的系统的方法。

公开(公告)号：US06745067B1

公开(公告)日：2004-06-01

申请号：US09786902

申请日：2001-03-09

Applicant: James M. Zavislan ,  Roger J. Greenwald

Inventor： James M. Zavislan ,  Roger J. Greenwald

IPC: A61B600

CPC classification number: G02B21/34 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0088 ,  A61B5/445 ,  A61B5/6842 ,  A61B5/6843 ,  A61B5/704 ,  G01N2001/282 ,  G02B21/002

Abstract: A system is provided for marking on a recording medium (36), such as a label, the location of imaged tissue with respect to an exposed surface of the tissue (34). Tissue is imaged by a microscope (11) capable of imaging sections of the tissue below the exposed tissue surface through optics. A ring (32) applied to the surface of the tissue stabilizes the tissue to the optics and localizes a portion of the tissue surface through an aperture in the ring. An actuator (38) is connected to both the ring and the microscope for moving the ring to adjust the position of the tissue with respect to the optics, thereby allowing an operator of the system to survey different images of tissue sections with the microscope.

Abstract translation: 提供了一种用于在诸如标签的记录介质（36）上标记相对于组织（34）的暴露表面的成像组织的位置的系统。 通过显微镜（11）对组织进行成像，该显微镜能够通过光学元件在组织表面下方的组织成像。 应用于组织表面的环（32）将组织稳定到光学元件，并通过环中的孔定位组织表面的一部分。 致动器（38）连接到环和显微镜两者以移动环以调节组织相对于光学器件的位置，从而允许系统的操作者用显微镜检测组织切片的不同图像。

公开(公告)号：US06577394B1

公开(公告)日：2003-06-10

申请号：US09641798

申请日：2000-08-18

Applicant: James M. Zavislan

Inventor： James M. Zavislan

IPC: G01J400

CPC classification number: G01J4/00 ,  G02B21/0032 ,  G02B21/0056 ,  G02B21/0068

Abstract: The quality of images produced by confocal microscopy, and especially scanning laser confocal microscopy, is enhanced especially for images obtained in turbid mediums such as many biological tissue specimens, by reducing speckle from scatterers that exist outside (above and below) the section which is being imaged by utilizing sheared beams, both of which are focused to laterally or vertically offset spots and polarizing the beams to have opposite senses of circular polarization (right and left handed circular polarization). The return light from the section of certain polarization is detected after passing through the confocal aperture of the confocal microscope. Images can be formed using optical coherence detection of the return light. Light from scatterers outside the section of interest, which are illuminated by both of the sheared beams, interfere thereby reducing speckle due to such scatterers, and particularly scatters which are adjacent to the section being imaged. Sheared beams having orthogonal linear polarization, as may be obtained from a Wollaston or Nomarski prism are converted into circularly polarized beams of opposite polarization sense by a quarter wave plate and focused into laterally displaced spots. A Dyson type lens is used to obtain sheared beams which when focused form vertically displaced spots. The optical signals representing reflections from the section are derived by polarizing optics which may either be a polarizing beamsplitter in the incident beam path or a retarder and analyzer. The retarder may be selected to provide different polarization phase shifts of the return light, and with the analyzer, detects the degree of elliptical polarization representing the optical activity and circular dichroism producing the optical signal representing the image.

Abstract translation: 通过共聚焦显微镜，特别是扫描激光共焦显微镜产生的图像的质量，特别是对于在诸如许多生物组织样本的混浊介质中获得的图像而言，通过减少存在于外部（上方和下方）的散射体的斑点 通过使用剪切光束成像，这两个光束被聚焦成横向或垂直偏移光斑并且使光束偏振以具有圆偏振（右和左旋圆偏振）的相反感。 在通过共聚焦显微镜的共聚焦孔之后检测来自某些偏振部分的返回光。 可以使用返回光的光学相干检测来形成图像。 由两束剪切光束照亮的感兴趣部分之外的散射体的光会干扰，从而减少由于这种散射体引起的斑点，特别是与被成像的部分相邻的散射。 具有从Wollaston或Nomarski棱镜获得的正交线偏振的剪切光束被四分之一波片转换成具有相反偏振感的圆偏振光束并聚焦到横向移位的光斑中。 Dyson型透镜用于获得剪切梁，当聚焦形成垂直位移点时。 表示来自该部分的反射的光学信号由偏振光学器件得到，其可以是入射光束路径中的偏振分束器或延迟器和分析器。 可以选择延迟器以提供返回光的不同偏振相移，并且与分析仪一起检测表示光学活动的椭圆偏振度和产生表示图像的光信号的圆二色性。

公开(公告)号：US06424852B1

公开(公告)日：2002-07-23

申请号：US08942431

申请日：1997-10-01

Applicant: James M. Zavislan

Inventor： James M. Zavislan

IPC: A61B500

CPC classification number: A61B5/6842 ,  A61B5/0068 ,  A61B5/061 ,  A61B5/441 ,  A61B5/444 ,  A61B5/445 ,  A61B5/6834 ,  A61B5/6835 ,  A61B5/6843 ,  A61B5/704

Abstract: An improved system for confocal imaging within dermal tissue of a patient is provided which minimizes instability in confocal images by reducing the relative motion of the tissue with respect to the confocal imaging optics of the system. The system includes a mechanism for maintaining an area of skin tissue under stress by application of force at the edges of the area, and an imaging head coupled to this mechanism for imaging the stressed skin. The mechanism includes a mechanical structure, such as a platen, brace, or attachment, which both supports the imaging head of the system and applies stress to a limited surface area of the tissue to minimize skin motion during confocal imaging.

Abstract translation: 提供了一种用于患者真皮组织内的共焦成像的改进系统，其通过减少组织相对于系统的共聚焦成像光学器件的相对运动而使共焦图像中的不稳定性最小化。 该系统包括用于通过在该区域的边缘处施加力来保持应力下的皮肤组织的面积的机构，以及耦合到该机构的用于对应力皮肤成像的成像头。 该机构包括机械结构，例如压板，支架或附件，其均支撑系统的成像头部，并将应力施加到组织的有限表面区域，以使共聚焦成像期间的皮肤运动最小化。