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公开(公告)号：US09128024B2
公开(公告)日：2015-09-08
申请号：US11020387
申请日：2004-12-22
Applicant: Roger J. Greenwald , James M. Zavislan
Inventor： Roger J. Greenwald , James M. Zavislan
CPC classification number: G01N21/0303 , B01L3/508 , B01L2300/043 , B01L2300/0609 , B01L2300/0654 , B01L2300/0672 , B01L2300/0822 , B01L2400/0683 , G01N1/36 , G01N2021/0339 , G01N2021/0342 , G01N2021/0364 , G02B21/0028 , G02B21/34
Abstract: A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. Selecting an immersion liquid, which equals the refractive index of the near surface tissues, minimizes wavefront distortion which may result from an effectively corrugated surface of the specimen.
Abstract translation: 用于组织标本的托盘或保持器，特别是切除的组织，例如活检标本，与共聚焦成像系统一起使用。 托盘在其中携带的样本成像后可以是一次性的，或可以归档样品。 一个窗口支撑样本。 安装在托盘内的夹具可以约束组织。 将合适的袋安装在托盘外侧的托盘的一侧，其中放置有试样。 在成像期间，将样品浸入包含在托盘中的液体中，该折射率与组织的折射率非常匹配。 该袋还包含一种优选地具有与托盘中的液体相同的指数的折射率匹配液体。 选择等于近表面组织的折射率的浸没液体可以最小化可能由试样的有效波纹表面产生的波前失真。
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2.发明申请公开(公告)号：US20100137710A1
公开(公告)日：2010-06-03
申请号：US12658036
申请日：2010-02-01
Applicant: James M. Zavislan , Roger J. Greenwald
Inventor： James M. Zavislan , Roger J. Greenwald
IPC: A61B6/00
CPC classification number: G02B21/34 , A61B5/0066 , A61B5/0068 , A61B5/0088 , A61B5/445 , A61B5/6842 , A61B5/6843 , A61B5/704 , G01N2001/282 , G02B21/002
Abstract: A system is provided for marking on a recording medium (36), such as a label, the location of imaged tissue with respect to an exposed surface of the tissue (34). Tissue is imaged by a microscope (11) capable of imaging sections of the tissue below the exposed tissue surface through optics. A ring (32) applied to the surface of the tissue stabilizes the tissue to the optics and localizes a portion of the tissue surface through an aperture in the ring. An actuator (38) is connected to both the ring and the microscope for moving the ring to adjust the position of the tissue with respect to the optics, thereby allowing an operator of the system to survey different images of tissue sections with the microscope.
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公开(公告)号：US06710875B1
公开(公告)日：2004-03-23
申请号：US09641795
申请日：2000-08-18
Applicant: James M. Zavislan
Inventor： James M. Zavislan
IPC: G01J400
CPC classification number: G02B21/0056 , G01J4/00 , G02B21/0032 , G02B21/0068
Abstract: The quality of images produced by confocal microscopy, and especially scanning laser confocal microscopy, is enhanced especially for images obtained in turbid mediums such as many biological tissue specimens, by reducing speckle from scatterers that exist outside (above and below) the focal plane region which is being imaged by utilizing sheared beams, both of which are focused to spots in the focal or image plane (region of interest) and polarizing the beams to have opposite senses of circular polarization (right and left handed circular polarization). The return light from the image plane of certain polarization is detected after passing through the confocal aperture of the confocal microscope. Light from scatterers outside the region of interest, which are illuminated by both of the sheared beams, interfere thereby reducing speckle due to such scatterers, and particularly scatters which are adjacent to the image plane. Sheared beams having orthogonal linear polarization, as may be obtained from a Wollaston or Nomarski prism are converted into circularly polarized beams of opposite polarization sense by a quarter wave plate. The optical signals representing reflections from the focal plane are derived by polarizing optics which may either, be a polarizing beamsplitter in the incident beam path or with a retarder and analyzer. The retarder may be selected to provide different polarization phase shift of the return light, and with the analyzer, detects the degree of elliptical polarization representing the optical activity and circular dichroism producing the optical signal representing the image.
Abstract translation: 通过共聚焦显微镜，特别是扫描激光共聚焦显微镜产生的图像的质量，特别是对于在诸如许多生物组织样本的混浊介质中获得的图像，通过减少焦平面区域外（高于和低于）的散射体的斑点而被增强 通过利用剪切光束进行成像，两者都被聚焦到焦点或图像平面（感兴趣区域）中的斑点，并且使光束偏振以具有相反的圆偏振感（右和左旋圆偏振）。 在通过共聚焦显微镜的共聚焦孔之后，检测出来自某些偏振图像平面的返回光。 由两束剪切光束照射的感兴趣区域之外的散射体的光会因此而减少由于这种散射体引起的斑点，特别是与图像平面相邻的散射。 具有从Wollaston或Nomarski棱镜获得的具有正交线性极化的剪切梁被四分之一波片转换为具有相反偏振感的圆偏振光束。 表示来自焦平面的反射的光学信号由偏振光学器件衍生，其可以是入射光束路径中的偏振分束器或者延迟器和分析器。 可以选择延迟器以提供返回光的不同的偏振相移，并且利用分析仪检测表示光学活动的椭圆偏振度和产生表示图像的光信号的圆二色性。
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公开(公告)号：US06668186B1
公开(公告)日：2003-12-23
申请号：US09438065
申请日：1999-11-10
Applicant: James M. Zavislan , Roger J. Greenwald
Inventor： James M. Zavislan , Roger J. Greenwald
IPC: A61B600
CPC classification number: G02B26/12 , A61B18/20 , A61B18/203 , A61B90/20 , A61B2018/00452 , A61B2018/00636 , A61B2562/0242 , G02B21/0012 , G02B21/0028
Abstract: An improved system for cellular surgery which includes a laser for producing a laser beam, and confocal optics for scanning and focusing the laser beam in tissue and generating confocal images of the tissue in accordance with returned light from the tissue. The confocal images are visualized on a display. The system includes a controller for enabling the operator to select one or more cells of the tissue in the displayed confocal images for surgical treatment. The controller operates the laser and confocal optics in a first mode to treat the tissue when the confocal optics focus the laser beam at least one region associated with the selected cells in the tissue, but at all other times operates the laser and confocal optics in a second mode which does not damage the tissue. The treatment may be localized to concentrate the energy of the laser to the region including the selected cell or cells, or the treatment may be non-localized to distribute the energy of the laser to the region which includes the selected cell(s) and also the cells of the tissue surrounding such selected cell(s). In another embodiment, an apparatus is provided having a confocal imaging system, which focuses a first laser beam through confocal optics to tissue and provides confocal images of the tissue, and a treatment system which focuses a second laser beam through the confocal optics coaxial with the first laser beam for treating at one or more selected locations in the imaged tissue.
Abstract translation: 一种用于细胞手术的改进的系统，其包括用于产生激光束的激光器和用于在组织中扫描和聚焦激光束并根据来自组织的返回光产生组织的共聚焦图像的共聚焦光学器件。 共焦图像在显示器上可视化。 该系统包括用于使操作者能够选择所显示的共聚焦图像中的组织的一个或多个细胞用于外科治疗的控制器。 控制器以第一模式操作激光和共聚焦光学器件，以在共焦光学器件将激光束聚焦到与所选择的细胞相关联的至少一个区域在组织中时处理组织，但是在所有其它时间将激光和共聚焦光学器件操作在 不损伤组织的第二模式。 治疗可以被定位以将激光的能量集中到包括所选择的细胞或细胞的区域，或者治疗可以非局部化以将激光的能量分布到包括所选细胞的区域，并且还 围绕这样选择的细胞的组织的细胞。 在另一个实施例中，提供一种具有共焦成像系统的设备，该共焦成像系统将第一激光束通过共聚焦光学器件聚焦到组织并提供组织的共聚焦图像;以及处理系统，其将第二激光束通过与 第一激光束用于在成像组织中的一个或多个选定位置处理。
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公开(公告)号：US5786585A
公开(公告)日：1998-07-28
申请号：US375216
申请日：1995-01-19
Applicant: Jay M. Eastman , James M. Zavislan
Inventor： Jay M. Eastman , James M. Zavislan
CPC classification number: G06K7/10881 , G02B26/10 , G02B27/4227 , G06K7/10653 , G06K7/1098 , G06K2007/10524 , G06K2207/1013 , G06K2207/1016
Abstract: A miniature scan engine module for bar code reading and data collection systems utilizes a light source 44 and a light collector 42, which in one embodiment, are flexurally supported on a platform 62 which reciprocates 88 on pivots defined by flexures 46, 48 or 96. The optical collector faces the bar code and pivots with the scanning beam source (a laser diode). A diffraction grating or Fresnel lens on the surface of the optical collector which faces the code directs the incoming light so that it propagates internally in a substrate within the body of the collector, i.e. in the optic itself and without air paths which require additional volume in the module, to a photodetector. The scan engine can be configured so that it occupies a volume of less than 1 cubic inch. A data collection system, in the form of a portable terminal 10, has a housing which provides the handle 12 of a scanning accessory. The housing of the accessory has a receptacle for a terminal unit 14 which is separable from the accessory's housing.
Abstract translation: 用于条形码读取和数据收集系统的微型扫描引擎模块使用光源44和光收集器42，其在一个实施例中弯曲地支撑在平台62上，平台62在由挠曲件46,48或96限定的枢轴上往复运动88。 光收发器面对条形码并与扫描光束源（激光二极管）枢转。 面向代码的光学收集器表面上的衍射光栅或菲涅耳透镜引导入射光，使得其在集电体的主体内的衬底内部传播，即在光学器件本身中，并且没有需要额外体积的空气路径 该模块到光电检测器。 扫描引擎可以被配置为使其占据小于1立方英寸的体积。 以便携式终端10的形式的数据收集系统具有提供扫描附件的手柄12的壳体。 附件的壳体具有用于终端单元14的插座，其可与附件的壳体分离。
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Patent Agency Ranking6.发明授权
公开(公告)号：US5742389A
公开(公告)日：1998-04-21
申请号：US322244
申请日：1994-10-12
Applicant: James M. Zavislan , Jay M. Eastman , Robert J. Hutchison
Inventor： James M. Zavislan , Jay M. Eastman , Robert J. Hutchison
CPC classification number: G01J3/06 , G01J3/02 , G01J3/0202 , G01J3/0256 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/18 , G01J3/28 , G01J3/502 , G01J3/524 , G01J2003/2866
Abstract: A spectrophotometer which is highly manufacturable at minimum cost nevertheless provides precision of measurement of spectra components of light which is projected therein by maintaining precise optical alignment of optical and electrical components thereof. These components are mounted in a module which is contained in a housing having an entrance aperture which defines an object area for light the spectrum of which is measured by a photodetector in the module at an image area. The module has a base plate provided by a printed circuit board on which a closed wall encompasses an area (a corral) on one side of the circuit board. The wall is a one piece structure which extends to the vicinity of the edge of the board. It is assembled with the board as a unitary structure so that the assembly is made torsionally rigid and resists bending in the plane of the board. The module may be of sufficiently small size so as to be located in a housing which is hand held, thereby providing a hand-held spectrophotometer.
Abstract translation: 然而，以最小成本高度可制造的分光光度计提供了通过保持其光学和电气部件的精确光学对准来投射在其中的光的光谱分量的测量的精度。 这些部件安装在一个模块中，该模块包含在具有入射孔的壳体中，该入口孔限定光的对象区域，其光谱由图像区域中的模块中的光电检测器测量。 模块具有由印刷电路板提供的底板，封闭的壁围绕电路板一侧的区域（畜栏）。 该壁是延伸到板的边缘附近的单件结构。 它与板组装成一体的结构，使得组件制成扭转刚性并抵抗板的平面中的弯曲。 模块可以具有足够小的尺寸，以便位于手持的壳体中，从而提供手持式分光光度计。
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公开(公告)号：US5701175A
公开(公告)日：1997-12-23
申请号：US691620
申请日：1996-08-02
Applicant: David A. Kostizak , James M. Zavislan
Inventor： David A. Kostizak , James M. Zavislan
CPC classification number: G06F3/03543 , G01J3/02 , G01J3/0272 , G01J3/0278 , G01J3/0291 , G06F3/03544
Abstract: A spectrophotometer mouse is provided for making color spectrum measurements of desired areas on a surface over which the mouse is movable. The spectrophotometer mouse includes a housing shaped to conform to the hand of an operator, and a spectrophotometer in the housing having an input (such as a light receiving aperture) for measuring the color spectrum of the target area on the surface. The mouse has a position sensing encoder which is coupled to a programmed computer for identifying the position of the mouse on the surface. This programmed computer may be internal or external of the housing. The computer is used for locating the target area on the surface with reference to a pointer on the mouse, and then detecting when an operator has moved the mouse such that the input of the spectrophotometer is substantially coincident with the located target area. The computer automatically actuates the spectrophotometer so that the spectrum of the light from the target area is received at the input of the spectrophotometer and is measured. In addition to providing color spectrum measurements of target areas on a surface, the position sensing features of the mouse can also be operated as a typical computer-type mouse for command input to a graphical user interface. Thus, the operator can use the spectrophotometer mouse to measuring the color spectrum of target areas on the surface, or as a typical computer-type mouse.
Abstract translation: 提供分光光度计鼠标，用于对鼠标可移动的表面上的期望区域进行色谱测量。 分光光度计鼠标包括成形为符合操作者的手的壳体，以及壳体中的分光光度计，其具有用于测量表面上的目标区域的色谱的输入（例如光接收孔）。 鼠标具有位置感测编码器，其耦合到编程的计算机，用于识别鼠标在表面上的位置。 该编程的计算机可以是外壳的内部或外部。 计算机用于参照鼠标上的指示器来定位表面上的目标区域，然后检测操作者何时移动鼠标，使得分光光度计的输入与所定位的目标区域基本一致。 计算机自动启动分光光度计，使得来自目标区域的光谱在分光光度计的输入处被接收并被测量。 除了提供表面上的目标区域的色谱测量之外，鼠标的位置感测特征也可以作为用于向图形用户界面输入命令的典型的计算机类型的鼠标来操作。 因此，操作者可以使用分光光度计鼠标来测量表面上目标区域的色谱，或者作为典型的计算机型鼠标。
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8.发明授权公开(公告)号：US09052523B2
公开(公告)日：2015-06-09
申请号：US13385980
申请日：2012-03-19
Applicant: Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
Inventor： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
CPC classification number: G02B21/368 , B01L3/508 , B01L2200/0642 , B01L2300/021 , B01L2300/043 , B01L2300/044 , B01L2300/0609 , B01L2300/0822 , B01L2300/123 , G01N2001/315 , G02B21/0012 , G02B21/26 , G02B21/33 , G02B21/34
Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible by a microscope through the window of the base member.
Abstract translation: 用于通过共聚焦显微镜或其他光学成像显微镜以方便光学切片的方向从患者保持外科手术曝光的组织的样本的盒。 盒包括具有刚性光学透明窗口的基部构件，组织样本位于该基部构件上，柔性膜可定位在包括窗口的基部构件的主要部分上方，以及具有穿过其的孔的上部构件，其可覆盖 在膜和窗户之间提供封闭的腔，密封组织样本。 组织样本的边缘可以相对于窗户定位，并且通过在组织样本周围的多个点或位置处形成在膜和窗之间的结合保持在该位置。 通过显微镜通过基底构件的窗口可以保持保留在空腔中的样品。
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公开(公告)号：US07047064B1
公开(公告)日：2006-05-16
申请号：US09579599
申请日：2000-05-26
Applicant: James M. Zavislan , Jay M. Eastman
Inventor： James M. Zavislan , Jay M. Eastman
IPC: A61B6/00
CPC classification number: A61B5/444 , A61B5/0059 , A61B5/0064 , A61B5/0068 , A61B2562/146
Abstract: An imaging apparatus is provided for imaging tissue samples substantially beneath the surface of the tissue sample. The apparatus includes an objective lens and a window defining a tissue contacting surface in pressure contacting relationship with the surface of the tissue sample when the tissue sample is imaged by the objective lens to view tissue structures for pathological applications. The objective lens focuses an illumination beam through the window to the tissue sample and receives returned reflected light of the beam representative of one or more sections of the tissue sample. The apparatus enables a method for in vivo observation of tissue for diagnosis of conditions substantially beneath the surface of the tissue sample. Both two and three-dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
Abstract translation: 提供了一种成像设备，用于基本上在组织样品的表面下方对组织样本进行成像。 该装置包括物镜和窗口，当组织样本被物镜成像以观察用于病理应用的组织结构时，限定与组织样本表面压力接触的组织接触表面。 物镜将照明光束通过窗口聚焦到组织样本并接收代表组织样本的一个或多个部分的光束的返回反射光。 该装置能够实现用于体内观察组织以用于诊断基本上在组织样品表面下的条件的方法。 可以提供二维和三维成像用于诊断和定位基底细胞癌和黑素瘤，并且可以在切除前使肿瘤边界可视化。
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公开(公告)号：US5995867A
公开(公告)日：1999-11-30
申请号：US44355
申请日：1998-03-19
Applicant: James M. Zavislan , Roger J. Greenwald
Inventor： James M. Zavislan , Roger J. Greenwald
CPC classification number: G02B26/12 , A61B18/20 , G02B21/0012 , G02B21/0028 , A61B18/203 , A61B2018/00452 , A61B2018/00636 , A61B2562/0242 , A61B90/20
Abstract: An improved system for cellular surgery which includes a laser for producing a laser beam, and confocal optics for scanning and focusing the laser beam in tissue and generating confocal images of the tissue in accordance with returned light from the tissue. The confocal images are visualized on a display. The system includes a controller for enabling the operator to select one or more cells of the tissue in the displayed confocal images for surgical treatment. The controller operates the laser and confocal optics in a first mode to treat the tissue when the confocal optics focus the laser beam at at least one region associated with the selected cells in the tissue, but at all other times operates the laser and confocal optics in a second mode which does not damage the tissue. The treatment may be localized to concentrate the energy of the laser to the region including the selected cell or cells, or the treatment may be non-localized to distribute the energy of the laser to the region which includes the selected cell(s) and also the cells of the tissue surrounding such selected cell(s). In another embodiment, an apparatus is provided having a confocal imaging system, which focuses a first laser beam through confocal optics to tissue and provides confocal images of the tissue, and a treatment system which focuses a second laser beam through the confocal optics coaxial with the first laser beam for treating at one or more selected locations in the imaged tissue.
Abstract translation: 一种用于细胞手术的改进的系统，其包括用于产生激光束的激光器和用于在组织中扫描和聚焦激光束并根据来自组织的返回光产生组织的共聚焦图像的共聚焦光学器件。 共焦图像在显示器上可视化。 该系统包括用于使操作者能够选择所显示的共聚焦图像中的组织的一个或多个细胞用于外科治疗的控制器。 当共焦光学器件将激光束聚焦在与组织中选定细胞相关联的至少一个区域时，控制器以第一模式操作激光和共聚焦光学器件来处理组织，但是在所有其它时间将激光和共聚焦光学器件 不损坏组织的第二模式。 治疗可以被定位以将激光的能量集中到包括所选择的细胞或细胞的区域，或者治疗可以非局部化以将激光的能量分布到包括所选细胞的区域，并且还 围绕这样选择的细胞的组织的细胞。 在另一个实施例中，提供一种具有共焦成像系统的设备，该共焦成像系统将第一激光束通过共聚焦光学器件聚焦到组织并提供组织的共聚焦图像;以及处理系统，其将第二激光束通过与 第一激光束用于在成像组织中的一个或多个选定位置处理。
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