公开(公告)号：US09343494B2

公开(公告)日：2016-05-17

申请号：US13411103

申请日：2012-03-02

申请人： Seung Ah Lee ,  Guoan Zheng ,  Benjamin Judkewitz ,  Shuo Pang ,  Jigang Wu ,  Changhuei Yang

发明人： Seung Ah Lee ,  Guoan Zheng ,  Benjamin Judkewitz ,  Shuo Pang ,  Jigang Wu ,  Changhuei Yang

IPC分类号： H01L27/146

CPC分类号： H01L27/14629 ,  H01L27/14621

摘要： A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

摘要翻译： 具有引导层和光检测器层的光引导像素。 引导层具有光导。 光检测器层具有接收光导通路的光检测元件。 光导可以包括用于将发射引导到光检测元件的滤光器。

公开(公告)号：US08970671B2

公开(公告)日：2015-03-03

申请号：US13032449

申请日：2011-02-22

申请人： Sri Rama Prasanna Pavani ,  Changhuei Yang

发明人： Sri Rama Prasanna Pavani ,  Changhuei Yang

IPC分类号： H04N13/02 ,  G02B21/16 ,  G02B21/36 ,  G02B27/22

CPC分类号： H04N13/207 ,  G02B21/16 ,  G02B21/361 ,  G02B27/2242 ,  G02B27/2285 ,  H04N13/221 ,  H04N13/254

摘要： Embodiments of the present invention relate a nondiffracting beam detection module for generating three-dimensional image data that has a surface layer having a first surface and a light transmissive region, a microaxicon, and a light detector. The microaxicon receives light through the light transmissive region from outside the first surface and generates one or more detection nondiffracting beams based on the received light. The light detector receives the nondiffracting beams and generates three-dimensional image data associated with an object located outside the first surface based on the one or more detection nondiffracting beams received. In some cases, the light detector can localize a three-dimensional position on the object associated with each detection nondiffracting beam received. In other cases, the light detector can determine perspective projections based on the detection nondiffracting beams received and generates the three-dimensional image data, using tomography, based on the determined perspective projections.

摘要翻译： 本发明的实施例涉及一种用于产生具有具有第一表面和透光区域的表面层的三维图像数据的非衍射光束检测模块，微型透镜和光检测器。 微轴通过第一表面外部的透光区域接收光，并基于接收的光产生一个或多个检测非衍射光束。 光检测器基于接收的一个或多个检测非衍射光束接收非衍射光束并产生与位于第一表面外部的物体相关联的三维图像数据。 在某些情况下，光检测器可以定位与所接收的每个检测非衍射光束相关联的物体上的三维位置。 在其他情况下，光检测器可以基于所接收的检测非衍射光束来确定透视投影，并且基于所确定的透视投影，使用断层摄影产生三维图像数据。

公开(公告)号：US08660312B2

公开(公告)日：2014-02-25

申请号：US12690952

申请日：2010-01-21

申请人： Xiquan Cui ,  Changhuei Yang

发明人： Xiquan Cui ,  Changhuei Yang

IPC分类号： G06K9/00

CPC分类号： G01N21/45 ,  G01B11/2441 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/18 ,  G02B21/367

摘要： Embodiments of the present invention relate to a method for computing depth sectioning of an object using a quantitative differential interference contrast device having a wavefront sensor with one or more structured apertures, a light detector and a transparent layer between the structured apertures and the light detector. The method comprises receiving light, by the light detector, through the one or more structured apertures. The method also measures the amplitude of an image wavefront, and measures the phase gradient in two orthogonal directions of the image wavefront based on the light. The method can then reconstruct the image wavefront using the amplitude and phase gradient. The method can then propagate the reconstructed wavefront to a first plane intersecting an object at a first depth. In one embodiment, the method propagates the reconstructed wavefront to additional planes and generates a three-dimensional image based on the propagated wavefronts.

摘要翻译： 本发明的实施例涉及一种使用具有一个或多个结构化孔径的波前传感器，光检测器和结构化孔径与光检测器之间的透明层的定量差分干涉对比装置来计算物体的深度截面的方法。 该方法包括通过光检测器接收通过一个或多个结构化孔的光。 该方法还测量图像波前的幅度，并且基于光测量图像波前的两个正交方向上的相位梯度。 该方法可以使用幅度和相位梯度来重构图像波前。 该方法然后可以将重建的波前传播到在第一深度与物体相交的第一平面。 在一个实施例中，该方法将重建的波前传播到附加平面，并且基于传播的波前产生三维图像。

公开(公告)号：US08525998B2

公开(公告)日：2013-09-03

申请号：US12886320

申请日：2010-09-20

申请人： Zahid Yaqoob ,  Emily McDowell ,  Changhuei Yang

发明人： Zahid Yaqoob ,  Emily McDowell ,  Changhuei Yang

IPC分类号： G01B9/021

CPC分类号： G03H1/0005 ,  G03H2001/0083 ,  G03H2001/0268 ,  G03H2001/0413 ,  G03H2001/0415 ,  G03H2210/63 ,  G03H2222/56

摘要： An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering medium is illuminated by a signal beam generating at least one scattered beam. An interference pattern is recorded from the at least one scattered beam and the first beam. A second beam is generated in a direction opposite to the direction of the first beam, the second beam having a wavefront and a phase substantially opposite to a phase of the wavefront of the first beam, and the second beam is configured to enter the holographic recording medium. The second beam and the interference pattern interact to generate at least one reconstructed beam having a phase substantially opposite to a phase of the at least one scattered beam, and the at least one reconstructed beam is configured to be viewable through the scattering medium.

摘要翻译： 一种用于散射介质的光学相位处理系统。 第一光束具有方向和波前，并且第一光束被配置为进入全息记录介质。 散射介质由产生至少一个散射光束的信号光束照射。 从至少一个散射光束和第一光束记录干涉图案。 在与第一光束的方向相反的方向上产生第二光束，第二光束具有波前和与第一光束的波阵面的相位基本相反的相位，第二光束被配置为进入全息记录 中。 所述第二光束和所述干涉图案相互作用以产生具有与所述至少一个散射光束的相位基本相反的相位的至少一个重建光束，并且所述至少一个重建光束被配置为通过所述散射介质可观看。

公开(公告)号：US08325349B2

公开(公告)日：2012-12-04

申请号：US12638518

申请日：2009-12-15

申请人： Xiquan Cui ,  Lap Man Lee ,  Changhuei Yang

发明人： Xiquan Cui ,  Lap Man Lee ,  Changhuei Yang

IPC分类号： G01N9/02

CPC分类号： G02B21/33

摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique that may be used employs surface tension at a hydrophobic surface to passively pump the fluid sample through the fluid channel. Another technique uses electrodes to adjust the position of objects in the fluid channel. Another technique computationally adjusts the focal plane of an image wavefront measured using differential interference contrast (DIC) based on Young's interference by back propagating the image wavefront from the detection focal plane to a different focal plane. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.

摘要翻译： 本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。 可以使用的一种技术使用在疏水表面处的表面张力来动态地将流体样品泵送通过流体通道。 另一种技术使用电极来调节物体在流体通道中的位置。 另一种技术通过从检测焦平面反向传播图像波前到不同焦平面，基于杨氏干扰，使用差分干涉对比度（DIC）来计算地调整图像波前的焦平面。 这些技术可以单独使用或组合使用以提高OFM设备的能力。

公开(公告)号：US20120250027A1

公开(公告)日：2012-10-04

申请号：US13344550

申请日：2012-01-05

申请人： Guoan Zheng ,  Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer

发明人： Guoan Zheng ,  Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer

IPC分类号： G01B9/02 ,  G02B5/18 ,  G01J3/46

CPC分类号： G02B6/1226 ,  B82Y20/00 ,  G01N21/554 ,  G02B5/008 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0056 ,  G02B21/0068 ,  G02B21/14 ,  G02B27/52

摘要： A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical transfer function at the aperture by inducing a surface wave for interfering with transmission of light of a range of spatial frequency.

摘要翻译： 表面波辅助系统，具有具有表面和孔径的孔层，以及围绕孔的多个凹槽。 多个槽被配置为通过诱导表面波来干扰空间频率范围的光的透射来在孔处产生光学传递函数。

公开(公告)号：US20110234757A1

公开(公告)日：2011-09-29

申请号：US13069651

申请日：2011-03-23

申请人： Guoan Zheng ,  Changhuei Yang ,  Samuel Yang ,  Seung Ah Lee

发明人： Guoan Zheng ,  Changhuei Yang ,  Samuel Yang ,  Seung Ah Lee

IPC分类号： H04N13/02 ,  H04N7/18

CPC分类号： H04N5/349 ,  G01N15/147 ,  G01N15/1484 ,  G02B21/0008 ,  G02B21/36 ,  G06T3/4053

摘要： A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.

摘要翻译： 超分辨率光流体显微镜装置包括限定具有纵向轴线的流体通道的主体并且包括靠近流体通道的表面层。 表面层具有二维光检测器阵列，其构造成当物体移动通过流体通道时，接收通过流体通道的光并采样一系列子像素偏移的投影框。 超分辨率光流体显微镜装置还包括与二维光检测器阵列电子通信的处理器。 处理器被配置为使用超分辨率算法，并且基于子像素偏移的投影帧的序列和对象的运动矢量来生成对象的高分辨率图像。

公开(公告)号：US20110181884A1

公开(公告)日：2011-07-28

申请号：US12398050

申请日：2009-03-04

申请人： Xiquan Cui ,  Xin Heng ,  Lap Man Lee ,  Changhuei Yang

发明人： Xiquan Cui ,  Xin Heng ,  Lap Man Lee ,  Changhuei Yang

IPC分类号： G01N21/59

CPC分类号： G01N21/53 ,  G01N21/6458

摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.

摘要翻译： 本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。 可以使用的一种技术消除了覆盖光检测器层的孔径层。 其他技术保留孔径层，反转光源和光检测器的相对位置，使得光在通过流体通道之前通过孔层，到达光检测器。 另一种技术增加了用于控制移动通过流体通道的物体运动的光学镊子。 另一种技术增加了光纤束，以将来自光透射区域的光中继到远程光检测器。 另一种技术在流体通道的端部添加两个电极，以产生能够通过流体通道移动物体同时抑制旋转的电场。 这些技术可以单独使用或组合使用以提高OFM设备的能力。

公开(公告)号：US20110109962A1

公开(公告)日：2011-05-12

申请号：US12943818

申请日：2010-11-10

申请人： Meng Cui ,  Changhuei Yang

发明人： Meng Cui ,  Changhuei Yang

IPC分类号： G02B21/06 ,  G01B9/021

CPC分类号： G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

摘要： A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.

摘要翻译： 一种用于对样本进行成像的4-Pi显微镜，包括用于在空间点上将第一光束聚焦在一个或多个数字光相位共轭（DOPC）装置上的第一物镜，其中所述DOPC装置包括用于检测所述第一 通过样品传输并输入到传感器上的光束; 以及空间光调制器（SLM），用于响应于由传感器检测到的第一光束，输出作为第一光束的光学相位共轭的第二光束; 以及第二目的，其定位为将第一光束传输到传感器并将第二光束聚焦在空间点处的样本上，使得第一光束和第二光束相反传播并且两者都聚焦到空间点 。

公开(公告)号：US20100290049A1

公开(公告)日：2010-11-18

申请号：US12797132

申请日：2010-06-09

申请人： Changhuei Yang ,  Demetri Psaltis

发明人： Changhuei Yang ,  Demetri Psaltis

IPC分类号： G01N21/00

CPC分类号： G01N21/6458 ,  B82Y10/00 ,  B82Y20/00

摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light imaging elements in the bottom of the fluid channel may be used to image the object.

摘要翻译： 公开了一种光流体显微镜装置。 该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。 流体通道底部的光成像元件可用于成像物体。