摘要:
A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要:
The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要:
The present invention is directed to the field of prosthetic devices. More particularly, one embodiment of the present invention is directed to an artificial disc that can be used as a replacement for an intervertebral disc (e.g., a human intervertebral lumbar disc, a human intervertebral cervical disc and/or a human intervertebral thoracic disc).
摘要:
Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要:
A therapeutic agent-eluting stylet treats a catheter by at least temporarily locating the stylet in a lumen of an indwelling catheter placed into a patient. The therapeutic agent-carrying stylet provides a localized therapeutic effect to the catheter and patient by eluting one or more therapeutic agents directly into the lumen of the catheter, into the fluid within the catheter, into the fluid and tissue in contact with the catheter, and onto the surface of the catheter. By removal and replacement of the temporary stylet from the catheter, renewable therapeutic agent doses can be provided to a component, such as the lumen, of the catheter while the catheter remains within in a patient. One or more therapeutically effective doses of medicated agents can be tailored along the length of the stylet and controlled by the length of time by which the stylet remains installed in the catheter.
摘要:
The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要:
A bottle seal breaker cap breaks a foil substrate seal on the top of the body of a medicine or supplement bottle. It has one or more notches, preferably a single notch, extending up from the bottom peripheral lip of a bottle cap, including a cutting surface deep enough to cut into a sealed foil substrate installed for sanitary reasons on top of the body of a medicine or supplement bottle.
摘要:
A wireless apparatus and method for the measurement and monitoring of bioelectric signal patterns associated with EEG, EOG and EMG readings is provided. The apparatus is comprised of at least one measurement device employing the use of three bioelectric sensing electrodes, wherein at least one of the electrodes is configured for secure placement within the ear canal of an individual under medical surveillance. Acoustic stimulation may be provided directly into the ear canal of the individual via an auditory stimulus emitted from the measurement device for evoking brain activity and the subsequent measurement of bioelectric signal patterns associated with the evoked activity.
摘要:
A flood light lamp removal alarm for security lights mounted on or near a home, wherein the lights are designed to turn on automatically if a motion detector is triggered and the ambient light level is low, detects if the motion detector or any of the flood light lamps and sockets are moved out of position, either prior to a burglary or during the attempt to disable the flood light assembly.
摘要:
A seal breaker to break the seal of a container includes the container cap having either one or more slots with an adjacent rigid portion capable of penetrating the seal or one or more pointed projections capable of penetrating the seal or one or more pointed projections.