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公开(公告)号：US08055336B1
公开(公告)日：2011-11-08
申请号：US11871776
申请日：2007-10-12
申请人： Joseph H. Schulman , Yitzhak Zilberman , Kate E. Purnell , Martin J. Vogel , Adam Vogel, legal representative
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61B5/6882 , A61N1/36003 , A61N1/372 , A61N1/37205 , A61N2001/0578
摘要： A method of removing an implantable electronic microdevice by an integral removal loop or circumferential ring to facilitate removal of the implanted microdevice without additional surgery. The device is removed by pulling it along the surgically created implantation path. Optionally a radio-opaque tether provides a method of locating the implantable microdevice without additional surgery and attachment of one end of the tether to a radio-opaque marker provides a method of locating the end of the tether to facilitate removal of the implantable microdevice from living tissue.
摘要翻译： 一种通过整体移除环或周向环移除可植入电子微型装置的方法，以便于无需另外手术即可移除植入的微型装置。 通过沿着手术产生的植入路径拉动装置来移除该装置。 可选地，不透射线的系绳提供了一种定位可植入微型装置的方法，而无需额外的手术，并且将系绳的一端附接到不透射线的标记物提供了一种定位系绳端部以便于移除可植入微型装置从生活的方法 组织。
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公开(公告)号：US07957810B2
公开(公告)日：2011-06-07
申请号：US11926041
申请日：2007-10-28
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247 , A61N1/375 , H01L2224/16225 , Y10T29/49165
摘要： The present invention is a motion compensation system for a visual prosthesis to adapt a visual image to movement of a user's eyes and head. The system includes a camera providing a video signal, an eye movement tracking device, a head movement tracking device, and a video processing unit processing the video signal and correcting the video signal for eye and head movement. The corrected video signal is sent to an implanted neural stimulator including electrodes stimulating visual neurons to create a perception of the video image.
摘要翻译： 本发明是用于视觉假体的运动补偿系统，以使视觉图像适应用户的眼睛和头部的运动。 该系统包括提供视频信号的相机，眼动跟踪装置，头部移动跟踪装置和视频处理单元，其处理视频信号并校正视频信号以进行眼睛和头部运动。 校正的视频信号被发送到植入的神经刺激器，其包括刺激视觉神经元的电极以产生视频图像的感知。
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公开(公告)号：US07894911B2
公开(公告)日：2011-02-22
申请号：US11206484
申请日：2005-08-17
IPC分类号： A61N1/04
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247 , A61N1/375 , H01L2224/16225 , Y10T29/49165
摘要： The stimulation device is an improved array for neuro-stimulation. The electrode array of the stimulation device is ideally suited for a visual prosthesis for the restoration of sight in patients with lost or degraded visual function. The electrode array of the stimulation device improves connectivity between a prosthesis and neurons.
摘要翻译： 刺激装置是用于神经刺激的改进阵列。 刺激装置的电极阵列理想地适合视觉假体，用于在具有丢失或退化的视觉功能的患者中恢复视力。 刺激装置的电极阵列改善假体和神经元之间的连接。
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44.发明申请Logarithmic Light Intensifier for use with Photoreceptor-Based Implanted Retinal Prosthetics and those Prosthetics 有权用于基于光感受器的植入视网膜假体和这些假体的对数光增强剂公开(公告)号：US20090204212A1
公开(公告)日：2009-08-13
申请号：US12425236
申请日：2009-04-16
CPC分类号： A61N1/36046 , A61F9/08
摘要： This invention is for directly modulating a beam of photons onto the retinas of patients who have extreme vision impairment or blindness. Its purpose is to supply enough imaging energy to retinal prosthetics implanted in the eye which operate essentially by having light (external to the eye) activating photoreceptors, or photoelectrical material. The invention provides sufficient light amplification and does it logarithmically. While it has sufficient output light power, the output light level still remains at a safe level. Most preferred embodiments of this invention provide balanced biphasic stimulation with no net charge injection into the eye. Both optical and electronic magnification for the image, as for example, using an optical zoom lens, is incorporated. Otherwise, it would not be feasible to zoom in on items of particular interest or necessity. Without proper adjustment, improper threshold amplitudes would obtain, as well as uncomfortable maximum thresholds. Therefore, to adjust for these, a way of proper adjustment for the threshold amplitudes and maximum comfortable thresholds is provided. Furthermore, to the extent that the individual stimulation sites in the retina give different color perceptions, upon stimulation, then colors of the viewed scene is correlated with specific stimulation sites to provide a certain amount of color vision.
摘要翻译： 本发明用于将光束束直接调制到具有极端视力障碍或失明的患者的视网膜上。 其目的是为植入眼睛的视网膜假体提供足够的成像能量，其基本上通过使光（外部的眼睛）激活光感受器或光电材料。 本发明提供足够的光放大，并且它是对数的。 虽然它具有足够的输出光功率，但输出光级仍然保持在一个安全的水平。 本发明最优选的实施方案提供平衡的双相刺激，而没有净电荷注入眼睛。 包括用于图像的光学和电子倍率，例如使用光学变焦透镜。 否则，放大特别感兴趣或必要的项目是不可行的。 没有适当的调整，不正确的阈值振幅将获得，以及不舒适的最大阈值。 因此，为了适应这些，提供了适当调整阈值振幅和最大舒适阈值的方法。 此外，在视网膜中的个别刺激部位产生不同的颜色感觉的情况下，在刺激时，所观看场景的颜色与特定刺激部位相关，以提供一定量的色觉。
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公开(公告)号：US20080294224A1
公开(公告)日：2008-11-27
申请号：US11926056
申请日：2007-10-28
IPC分类号： A61N1/04
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247 , A61N1/375 , H01L2224/16225 , Y10T29/49165
摘要： The present invention is a visual color prosthesis. The prosthesis creates the perception of a color image by electrically stimulating visual neurons in patterns consistent with the electrically patterns naturally produced by the retina in response to a color image.
摘要翻译： 本发明是视觉色假体。 假体通过以与视网膜自然产生的响应于彩色图像的电图案一致的图案电刺激视觉神经元而产生彩色图像的感知。
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46.发明申请公开(公告)号：US20080169904A1
公开(公告)日：2008-07-17
申请号：US11885844
申请日：2005-12-20
IPC分类号： G08B5/22
CPC分类号： B60R25/00 , B60R25/33 , B60R2325/205 , G08B21/0244
摘要： An object locator system utilizes a microtransponder (12) that is used in association with an object to be located. A remote locator (10) transmits an encoded signal in which is embedded an identification code associated with the object to be located. The microtransponder (12) receives the encoded transmitted signal and processes such signal utilizing fast fourier transform techniques. The microtransponder (12) correlates the transformed received signal with a fast fourier transformed version of an identification code associated with the microtransponder (12) and upon detection of a correlation, transmits an acknowledgement signal to the remote locator (10). The remote locator (10) determines the distance to the microtransponder (12) based upon the round trip time from transmission of the coded signal to the microtransponder (12) to the receipt of the acknowledgement signal.
摘要翻译： 对象定位器系统利用与要定位的对象相关联使用的微转发器（12）。 远程定位器（10）发送编码信号，其中嵌入有与要被定位的对象相关联的识别码。 微型应答器（12）接收编码的发射信号，并利用快速傅立叶变换技术处理这种信号。 微转发器（12）将变换的接收信号与与微转发器（12）相关联的识别码的快速傅里叶变换版本相关，并且在检测到相关后，向远程定位器（10）发送确认信号。 远程定位器（10）基于从编码信号传输到微转发器（12）到接收到确认信号的往返时间确定到微型应答器（12）的距离。
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公开(公告)号：US07286883B2
公开(公告)日：2007-10-23
申请号：US11152444
申请日：2005-06-13
申请人： Joseph H. Schulman , Janusz Kuzma
发明人： Joseph H. Schulman , Janusz Kuzma
IPC分类号： A61N1/05
CPC分类号： H01R4/70 , A61N1/05 , A61N1/37205 , A61N1/3752 , H01R13/20 , H01R13/6273 , H01R24/20 , H01R24/28 , H01R2101/00 , H01R2201/12 , Y10S439/909
摘要： Methods are utilized for connecting electrically conductive wire to a miniature, implantable sensor or stimulator device for detecting electrical signals or stimulating living tissue. The implantable device has an electrically conductive end on its case which is intimately connected to a doorknob electrode for communicating electrical signals between the living tissue and the device by a biocompatible wire. A spring clip removably attaches to the doorknob electrode so that the wire may be easily attached to the doorknob electrode during surgery. An insulating rubber boot, which may be silicone, surrounds the case end, doorknob electrode, and spring clip to isolate the living tissue from the conductive components. The components are all biocompatible materials.
摘要翻译： 方法用于将导电线连接到用于检测电信号或刺激活体组织的微型可植入传感器或刺激器装置。 可植入装置在其壳体上具有导电端，其紧密连接到门把手电极，用于通过生物相容的导线传送活体组织和装置之间的电信号。 弹簧夹可拆卸地附接到门把手电极，使得线在手术期间可以容易地附接到门把手电极。 可以是硅树脂的绝缘橡胶套围绕壳体端，门把手电极和弹簧夹，以将活体组织与导电组件隔离。 组件都是生物相容性材料。
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48.发明授权System and apparatus for sensing pressure in living organisms and inanimate objects 有权用于感测生物体和无生命物体中的压力的系统和装置公开(公告)号：US07252005B2
公开(公告)日：2007-08-07
申请号：US10921750
申请日：2004-08-18
申请人： Joseph H. Schulman
发明人： Joseph H. Schulman
IPC分类号： G01L9/00
CPC分类号： A61B5/0031 , A61B5/0215 , A61B5/03 , A61B5/076 , A61B2560/0219 , A61B2560/0257 , A61B2562/0247 , A61N1/37205 , A61N1/3787 , G01L19/0645 , G01L19/086
摘要： System and apparatus for measuring pressure including a microelectronic device, an interface member attached to the microelectronic device, a pressure sensor having a diaphragm responsive to external pressure exerted upon the diaphragm, wherein the interface member is positioned between the microelectronic device and the pressure sensor and is attached to the pressure sensor providing a first cavity between the pressure sensor diaphragm and the interface member and wherein the pressure in the first cavity is set at an initial predetermined pressure.
摘要翻译： 用于测量压力的系统和装置，包括微电子器件，附接到微电子器件的接口部件，具有响应于施加在隔膜上的外部压力的隔膜的压力传感器，其中接口部件位于微电子器件和压力传感器之间， 附接到所述压力传感器，其在所述压力传感器膜片和所述界面构件之间提供第一空腔，并且其中所述第一腔体中的压力被设定在初始预定压力。
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49.发明授权Alumina insulation for coating implantable components and other microminiature devices 有权用于涂层可植入组件和其他微型设备的氧化铝绝缘公开(公告)号：US07235350B2
公开(公告)日：2007-06-26
申请号：US10969758
申请日：2004-10-20
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at a relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括厚度小于25微米，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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50.发明授权公开(公告)号：US07024249B2
公开(公告)日：2006-04-04
申请号：US10081346
申请日：2002-02-21
IPC分类号： A61N1/32
CPC分类号： A61N1/3727 , A61N1/37217 , A61N1/37223 , A61N1/37264
摘要： A magnetic control system for selectively enabling/disabling an implantable device's operation using externally applied pulsed magnetic means, e.g., a controlled electromagnet or the like. Typically, such implantable devices stimulate a neural pathway or muscle and/or block pain or muscle stimulation according to programmable settings. Preferably, once programmed from an external programmer, such implantable devices can operate “independently” using the externally provided programmed information. However, in certain circumstances, it may be desired to stop/pause the operation of such selected implanted device while not affecting other such devices. Accordingly, embodiments of the present invention include a magnetic sensor, preferably a magnetoresistive, Hall effect, saturated core reactors, or the like, to sense an externally provided magnetic field. By externally applying pulsed magnetic fields in sequences of controlled polarities, durations, intensities, etc., and sensing these identifiable sequences and transitions, the operation of the implantable device may be enabled/disabled.
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