公开(公告)号：US06750218B2

公开(公告)日：2004-06-15

申请号：US10227302

申请日：2002-08-26

申请人： Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shigeki Fujiwara ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Irie ,  Shoji Oda

发明人： Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shigeki Fujiwara ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Irie ,  Shoji Oda

IPC分类号： C07D48704

CPC分类号： C07D401/12 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  C07D215/46 ,  C07D217/22 ,  C07D237/34 ,  C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

摘要： 1,3 Diazines according to formula: and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering.

摘要翻译： 1,3根据式的二嗪类及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。

公开(公告)号：US06207667B1

公开(公告)日：2001-03-27

申请号：US09481544

申请日：2000-01-12

申请人： Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shigeki Fujiwara ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Irie ,  Shoji Oda

发明人： Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shigeki Fujiwara ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Irie ,  Shoji Oda

IPC分类号： A61K31535

CPC分类号： C07D401/12 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  C07D215/46 ,  C07D217/22 ,  C07D237/34 ,  C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

摘要： 1,3 Diazines according to formula (I): and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

摘要翻译： 1,3根据式（I）的二嗪类及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。 该化合物可用于治疗或预防细胞增殖性疾病如动脉硬化，血管重构，癌症和肾小球硬化。

公开(公告)号：US06169088A

公开(公告)日：2001-01-02

申请号：US09088199

申请日：1998-06-01

申请人： Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shigeki Fujiwara ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Irie ,  Shoji Oda

发明人： Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shigeki Fujiwara ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Irie ,  Shoji Oda

IPC分类号： A61K31495

CPC分类号： C07D401/12 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  C07D215/46 ,  C07D217/22 ,  C07D237/34 ,  C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

摘要： 1,3 Diazines and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

摘要翻译： 1,3二嗪及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。 该化合物可用于治疗或预防细胞增殖性疾病如动脉硬化，血管重构，癌症和肾小球硬化。

公开(公告)号：US6090334A

公开(公告)日：2000-07-18

申请号：US218145

申请日：1998-07-14

申请人： Kenji Matsuno ,  Nobuyuki Kato ,  Hiroo Ikegami ,  Setsuko Nakamaki ,  Kimio Takeuchi ,  Hotaka Fukabori ,  Yoshitsugu Maruhashi ,  Hideo Kurashima

发明人： Kenji Matsuno ,  Nobuyuki Kato ,  Hiroo Ikegami ,  Setsuko Nakamaki ,  Kimio Takeuchi ,  Hotaka Fukabori ,  Yoshitsugu Maruhashi ,  Hideo Kurashima

IPC分类号： B29C35/08 ,  B29C49/06 ,  B29C49/08 ,  B29C49/12 ,  B29C49/18 ,  B29C49/64 ,  B29C49/66 ,  B29C61/02 ,  B29K105/00 ,  B29L22/00 ,  B65D1/02

CPC分类号： B65D1/0284 ,  B29C49/12 ,  B29C49/18 ,  B29C49/649 ,  B65D1/0207 ,  B29B2911/14693 ,  B29B2911/147 ,  B29B2911/14713 ,  B29B2911/14906 ,  B29B2911/14933 ,  B29C2035/0822 ,  B29C2049/1219 ,  B29C49/06 ,  B29C49/66 ,  B29C61/02 ,  B29K2995/004 ,  B29L2031/7158 ,  Y10S264/906

摘要： A container obtained by biaxially stretch-blow-molding a resin. Except the mouth-and-neck portion, vicinities thereof and the center of the bottom portion, the container as a whole is reduced in thickness under a highly drawing condition without accompanied by whitening, and a portion constituting the bottom valley portions has an yielding load of not smaller than 25 kg/cm at 70.degree. C. The container exhibits excellent heat resistance, pressure resistance, shock resistance as well as self-standing ability.

摘要翻译： 通过双轴拉伸吹塑树脂获得的容器。 除了口颈部，其附近和底部的中心之外，容器整体在高拉伸条件下的厚度减小，而不伴随着白化，构成底部谷部的部分具有屈服载荷 在70℃下不小于25kg / cm 2。容器表现出优异的耐热性，耐压性，抗冲击性以及自立能力。

公开(公告)号：US5780300A

公开(公告)日：1998-07-14

申请号：US537210

申请日：1995-09-29

申请人： Spyridon Artavanis-Tsakonas ,  Mark Edward Fortini ,  Kenji Matsuno

发明人： Spyridon Artavanis-Tsakonas ,  Mark Edward Fortini ,  Kenji Matsuno

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K35/12 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P43/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/07 ,  C12N5/0797 ,  C12N5/10 ,  C12P21/02 ,  C12N5/08 ,  C12N5/02 ,  C12N5/06

CPC分类号： C12N5/0623 ,  C07K14/47 ,  C12N5/0018 ,  C12N5/0601 ,  A61K35/12 ,  A61K38/00 ,  C12N2501/42

摘要： The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.

公开(公告)号：US4805795A

公开(公告)日：1989-02-21

申请号：US140603

申请日：1987-12-28

申请人： Nobuyuki Sato ,  Hiroshi Matsubayashi ,  Seishichi Kobayashi ,  Minoru Mitsuhashi ,  Kenji Matsuno ,  Kazuhisa Ishibashi

发明人： Nobuyuki Sato ,  Hiroshi Matsubayashi ,  Seishichi Kobayashi ,  Minoru Mitsuhashi ,  Kenji Matsuno ,  Kazuhisa Ishibashi

IPC分类号： B23K26/18 ,  B23K26/24 ,  B23K26/26 ,  B23K26/32 ,  B23K35/22

CPC分类号： B23K35/224 ,  B23K26/18 ,  B23K26/244 ,  B23K26/262 ,  B23K26/32 ,  B23K26/322 ,  B23K2201/34 ,  B23K2203/04 ,  B23K2203/50 ,  Y10S220/29 ,  Y10T29/5185 ,  Y10T428/1355

摘要： There is here provided butt-welded cans made of steel plates having a carbon concentration of 0.02 to 0.09% by weight, the aforesaid butt-welded cans being characterized in that a coating film for preventing the adhesion of melted metal particles is applied to at least the inner surface of the weld portion and its vicinity of each can, and a carbon concentration index I of the weld portion satisfies the formula (1)I=(Iw/Ic).times.10.sup.3 .ltoreq.15 (1)wherein Iw is a K.alpha. X ray intensity, of carbon in the weld portion, measured by the EPMA method, andIc is a K.alpha. X ray intensity, of carbon in graphite, measured by the EPMA method.

摘要翻译： 这里提供了碳浓度为0.02〜0.09重量％的钢板对接焊接罐，上述对接焊接罐的特征在于，至少施加防止熔融金属颗粒粘附的涂膜 每个罐的焊接部分的内表面及其附近，并且焊接部分的碳浓度指数I满足式（1）I =（Iw / Ic）×103

公开(公告)号：US4595326A

公开(公告)日：1986-06-17

申请号：US648214

申请日：1984-09-07

申请人： Kenji Matsuno ,  Kazuhisa Ishibashi

发明人： Kenji Matsuno ,  Kazuhisa Ishibashi

IPC分类号： B23K11/24 ,  B23K11/06 ,  B23K11/30

CPC分类号： B23K11/309 ,  B23K11/063

摘要： There is provided a method of making a welded can body having a mash seam weld which includes a heat affected zone extending continuously in the longitudinal direction thereof and is formed with no pitting. The weld is formed by mash seam welding a lapped portion of a can body preform made of a surface treated steel sheet while allowing an alternating current to flow through the lapped portion via a water-cooled elongated electrode and a water-cooled rotary electrode. The alternating current has a crest factor satisfying an expression 1.5.ltoreq.Ip/Ie.ltoreq.2.0, where Ie and Ip designate an effective value and a peak value, respectively, of the alternating current.

摘要翻译： 提供了一种制造具有压薄缝焊接的焊接罐体的方法，其包括在其纵向方向上连续延伸的热影响区域，并且没有形成点蚀。 焊接是通过压薄焊接由表面处理钢板制成的罐体预制件的重叠部分，同时允许交流电流通过水冷细长电极和水冷旋转电极流过研磨部分而形成的。 交流电流具有满足1.5≤Ip/ Ie <2.0的波峰因数，其中Ie和Ip分别表示交流电的有效值和峰值。

公开(公告)号：US4127158A

公开(公告)日：1978-11-28

申请号：US645931

申请日：1976-01-02

申请人： Kenji Matsuno

发明人： Kenji Matsuno

IPC分类号： B01J2/06 ,  B22F1/00 ,  B22F9/08 ,  B22F9/10 ,  B22F9/14

CPC分类号： B22F9/082 ,  B01J2/06 ,  B22F1/0051 ,  B22F9/10 ,  B22F9/14 ,  B22F2009/084 ,  B22F2009/086

摘要： A method of preparing hollow metallic bodies by contacting flat droplets of a molten metal with a liquid capable of readily gasifying at a temperature lower than the melting point of said metal. Upon contact the liquid gasifies under the flat droplets and the gas pushes up the center of the flat droplets. The edges of the droplets fall because the vapor near the edges goes around the edges. As the middle of the droplets rises the surface tension of the droplets brings the edges together thereby forming the hollow metallic body.

摘要翻译： 一种通过使熔融金属的扁平液滴与能够在低于所述金属的熔点的温度下容易气化的液体接触来制备中空金属体的方法。 接触后，液体在扁平液滴下气化，气体向上推动扁平液滴的中心。 由于靠近边缘的蒸气绕边缘，所以液滴的边缘落下。 当液滴的中间上升时，液滴的表面张力将边缘结合在一起，从而形成中空金属体。