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    Turing test based user authentication and user presence verification system, device, and method
    41.
    发明授权
    Turing test based user authentication and user presence verification system, device, and method 有权
    基于图灵测试的用户认证和用户存在验证系统，设备和方法

    公开(公告)号：US09081947B2

    公开(公告)日：2015-07-14

    申请号：US13976918

    申请日：2011-12-27

    申请人： Prashant Dewan ,  David M. Durham ,  Ling Huang ,  Karanvir S. Grewal ,  Xiaozhu Kang

    发明人： Prashant Dewan ,  David M. Durham ,  Ling Huang ,  Karanvir S. Grewal ,  Xiaozhu Kang

    IPC分类号： G06F21/32 ,  G06K9/78 ,  G06K9/00

    CPC分类号： G06F21/32 ,  G06K9/00288 ,  G06K9/00899

    摘要： A password-less method for authenticating a user includes capturing one or more images of a face of the user and comparing the one or more images with a previously collected face template. Randomly selected colored light and randomized blinking patterns are used to capture the images of the user. Such captured images are compared to previously collected face templates, thereby thwarting spoof attacks. A secret image, known only to the user and the device, is moved from one area of the display to another randomly selected area, using the movements of the user's head or face, thereby providing a Turing based challenge. Protected audio video path (PAVP) enabled devices and components are used to protect the challenge from malware attacks.

    摘要翻译： 用于认证用户的无密码方法包括捕获用户的脸部的一个或多个图像并将一个或多个图像与先前收集的面部模板进行比较。 随机选择的彩色光和随机闪烁图案用于捕获用户的图像。 将这样的拍摄图像与先前收集的面部模板进行比较，从而阻止欺骗攻击。 使用用户和设备已知的秘密图像使用用户头部或脸部的移动从显示器的一个区域移动到另一个随机选择的区域，从而提供基于图灵的挑战。 受保护的音频视频路径（PAVP）启用的设备和组件用于保护挑战免受恶意软件攻击。

    Identification and engineering of antibodies with variant Fc regions and methods of using same
    43.
    发明授权
    Identification and engineering of antibodies with variant Fc regions and methods of using same 有权
    具有变体Fc区的抗体的鉴定和工程及其使用方法

    公开(公告)号：US07960512B2

    公开(公告)日：2011-06-14

    申请号：US10902588

    申请日：2004-07-28

    申请人： Jeffrey Stavenhagen ,  Sujata Vijh ,  Christopher Rankin ,  Sergey Gorlatov ,  Ling Huang

    发明人： Jeffrey Stavenhagen ,  Sujata Vijh ,  Christopher Rankin ,  Sergey Gorlatov ,  Ling Huang

    IPC分类号： C12P21/08 ,  C07K16/00 ,  C07K17/00

    CPC分类号： A61K39/39558 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/005 ,  C07K2317/52 ,  C07K2317/732 ,  C07K2317/734

    摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

    摘要翻译： 本发明涉及包括变体Fc区的分子，特别是多肽，更特别是免疫球蛋白（例如，抗体），其中所述变体Fc区相对于野生型Fc区包含至少一个氨基酸修饰，所述变体Fc区 相对于包含野生型Fc区的可比分子，以更高的亲和力结合FcγRIIIA和/或FcγRIIA。 本发明的分子特别可用于预防，治疗或改善与疾病，病症或感染相关的一种或多种症状。 本发明的分子特别可用于治疗或预防需要由FcγR介导的效应细胞功能增强的功效（例如ADCC）的疾病或病症，例如癌症，感染性疾病和增强治疗功效 的治疗性抗体，其作用由ADCC介导。

    LARGE-FIELD UNIT-MAGNIFICATION PROJECTION OPTICAL SYSTEM
    45.
    发明申请
    LARGE-FIELD UNIT-MAGNIFICATION PROJECTION OPTICAL SYSTEM 有权
    大型放大投影光学系统

    公开(公告)号：US20090185290A1

    公开(公告)日：2009-07-23

    申请号：US12302824

    申请日：2006-12-04

    申请人： Tiejun Li ,  Ling Huang ,  Jun Wei

    发明人： Tiejun Li ,  Ling Huang ,  Jun Wei

    IPC分类号： G02B17/08

    CPC分类号： G02B17/08 ,  G02B13/26 ,  G03F7/70225 ,  G03F7/70791

    摘要： The present invention discloses a large-field unit-magnification projection optical system. The optical system includes an optical axis, a spherical concave reflection mirror; a lens group with positive refracting power arranged adjacent the mirror with an air space therebetween. The lens group includes a first plano-convex lens, a negative meniscus lens adjacent the plano-convex lens, a positive lens adjacent the negative meniscus lens, a negative double-convex lens spaced apart far from the positive lens, and a second plano-convex lens. The optical system further includes a pair of prisms each having respective first and second surface. The second surfaces are arranged adjacent the flat surface of the plano-convex lens element on opposite sides of the optical axis and the first surfaces are arranged adjacent object planes and image planes, respectively. Each lens in the lens group and the pair of prisms provide chromatic aberration correction in a spectral region that contains at least g, h and i-line wavelengths. In this projection optical system, the object plane is parallel to the image plane.

    摘要翻译： 本发明公开了一种大视场单位放大投影光学系统。 光学系统包括光轴，球面凹面反射镜; 具有正反射功率的透镜组，其布置在反射镜附近，其间具有空气空间。 透镜组包括第一平凸透镜，与平凸透镜相邻的负弯月透镜，邻近负弯月透镜的正透镜，与正透镜间隔开的负双凸透镜，以及第二平凸透镜， 凸透镜 光学系统还包括一对棱镜，每个棱镜具有相应的第一和第二表面。 第二面与光轴的相对侧的平凸透镜元件的平面相邻配置，第一面与物平面和像面分别配置。 透镜组中的每个透镜和一对棱镜在包含至少g，h和i线波长的光谱区域中提供色差校正。 在该投影光学系统中，物平面与图像平面平行。

    Covalent diabodies and uses thereof
    46.
    发明申请
    Covalent diabodies and uses thereof 有权
    共价双抗体及其用途

    公开(公告)号：US20070004909A1

    公开(公告)日：2007-01-04

    申请号：US11409339

    申请日：2006-04-17

    申请人： Leslie Johnson ,  Ling Huang

    发明人： Leslie Johnson ,  Ling Huang

    IPC分类号： C07K16/30

    CPC分类号： C07K16/283 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/626

    摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule.

    摘要翻译： 本发明涉及双抗体分子及其在治疗各种疾病和病症（包括免疫学疾病，感染性疾病，中毒和癌症）中的用途。 本发明的双抗体分子包含两个缔合以形成至少两个表位结合位点的多肽链，其可识别相同或不同抗原上相同或不同的表位。 另外，抗原可以来自相同或不同的分子。 双抗体分子的单个多肽链可以通过非肽键共价键共价结合，例如但不限于位于每个多肽链内的半胱氨酸残基的二硫键。 在具体实施方案中，本发明的双抗体分子还包含Fc区，其允许抗体样功能被改造成分子。

    Non-integer pixel sharing for video encoding
    47.
    发明申请
    Non-integer pixel sharing for video encoding 审中-公开
    用于视频编码的非整数像素共享

    公开(公告)号：US20060088104A1

    公开(公告)日：2006-04-27

    申请号：US10975731

    申请日：2004-10-27

    申请人： Stephen Molloy ,  Ling Huang

    发明人： Stephen Molloy ,  Ling Huang

    IPC分类号： H04N11/04 ,  H04N7/12 ,  H04B1/66 ,  H04N11/02

    CPC分类号： H04N19/423 ,  H04N19/43 ,  H04N19/523 ,  H04N19/80

    摘要： This disclosure describes video encoding techniques and video encoding devices that implement such techniques. In one embodiment, this disclosure describes a video encoding device comprising a motion estimator that generates non-integer pixel values for motion estimation, the motion estimator including a filter that receives at least three inputs of integer pixel values. The video encoding device also comprises a memory that stores the non-integer pixel values generated by the motion estimator, and a motion compensator that uses the stored non-integer pixel values for motion compensation.

    摘要翻译： 本公开描述了实现这种技术的视频编码技术和视频编码设备。 在一个实施例中，本公开描述了一种包括运动估计器的视频编码设备，该运动估计器产生用于运动估计的非整数像素值，运动估计器包括接收整数像素值的至少三个输入的滤波器。 视频编码装置还包括存储器，其存储由运动估计器生成的非整数像素值，以及运动补偿器，其使用存储的非整数像素值进行运动补偿。