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公开(公告)号:US06660520B2
公开(公告)日:2003-12-09
申请号:US09092218
申请日:1998-06-05
申请人: Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Lisa Kathleen Shilling , Min Wang , Edwina Imogen Wilding
发明人: Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Lisa Kathleen Shilling , Min Wang , Edwina Imogen Wilding
IPC分类号: C12N1500
CPC分类号: G01N33/5091 , A61K38/00 , C07K14/3156 , G01N33/5008 , G01N33/502 , G01N33/573 , G01N33/6872
摘要: The invention provides nrdE polypeptides and polynucleotides encoding nrdE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdE polypeptides to screen for antibacterial compounds.
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公开(公告)号:US06447773B1
公开(公告)日:2002-09-10
申请号:US09416874
申请日:1999-10-13
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
IPC分类号: A61K3848
CPC分类号: C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了clpL多肽和编码clpL多肽的DNA(RNA)和通过重组技术产生这种多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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公开(公告)号:US06344540B1
公开(公告)日:2002-02-05
申请号:US09363160
申请日:1999-07-28
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号: A61K3800
CPC分类号: C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要: The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了pai多肽和编码pai多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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公开(公告)号:US06335424B1
公开(公告)日:2002-01-01
申请号:US08979616
申请日:1997-11-25
申请人: Michael Terence Black , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , David Justin Charles Knowles , Anna Lisa Kosmatka , Jeffrey Mooney , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
发明人: Michael Terence Black , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , David Justin Charles Knowles , Anna Lisa Kosmatka , Jeffrey Mooney , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
IPC分类号: A61K3902
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12N9/90 , C12N15/52 , C12Y207/01002
摘要: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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公开(公告)号:US06310193B1
公开(公告)日:2001-10-30
申请号:US08940572
申请日:1997-09-30
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Nicola Gail Wallis
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Nicola Gail Wallis
IPC分类号: C07H2104
CPC分类号: C12N9/1205 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/3156 , C12N9/78 , C12N9/90 , C12Y207/01002
摘要: The invention provides MurC polypeptides and DNA (RNA) encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供MurC多肽和编码MurC多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用MurC多肽筛选抗菌化合物的方法。
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公开(公告)号:US6150340A
公开(公告)日:2000-11-21
申请号:US9494
申请日:1998-01-20
IPC分类号: G01N33/566 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P31/04 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12R1/445 , C12N15/63
CPC分类号: C07K14/31 , C12N9/1096 , A61K38/00 , A61K39/00 , Y10S435/883
摘要: The invention provides ratA polypeptides and DNA (RNA) encoding ratA polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratA polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了大鼠A多肽和编码大鼠A多肽的DNA(RNA)和通过重组技术产生此类多肽的方法。 还提供了利用大鼠A多肽筛选抗菌化合物的方法。
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公开(公告)号:US6136560A
公开(公告)日:2000-10-24
申请号:US242050
申请日:1999-02-08
IPC分类号: A61K38/00 , A61K39/00 , A61K48/00 , C12N9/10 , C12N15/31 , C12N15/10 , C12N15/52 , C12N15/62 , C12N15/63
CPC分类号: C12N9/1096 , A61K38/00 , A61K39/00 , A61K48/00
摘要: The invention provides ratB polypeptides and DNA (RNA) encoding ratB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratB polypeptides to screen for antibacterial compounds.
摘要翻译: PCT No.PCT / US98 / 05421 Sec。 371日期1999年2月8日 102(e)日期1999年2月8日PCT提交1998年3月20日PCT公布。 公开号WO98 / 41233 日期1998年9月24日本发明提供了编码大鼠B多肽的大鼠B多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用大鼠B多肽筛选抗菌化合物的方法。
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公开(公告)号:US5972651A
公开(公告)日:1999-10-26
申请号:US923772
申请日:1997-09-02
IPC分类号: G01N33/50 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569
CPC分类号: C07K14/3156 , A61K38/00 , A61K39/00
摘要: The invention provides ffh polypeptides and DNA (RNA) encoding ffh polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ffh polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了ffh多肽和编码ffh多肽的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还提供了利用ffh多肽筛选抗菌化合物的方法。
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公开(公告)号:US5965402A
公开(公告)日:1999-10-12
申请号:US922146
申请日:1997-08-25
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
CPC分类号: C07K14/31 , C07K16/1275 , C12N9/78 , C12Y305/04025 , A61K39/00
摘要: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供phoH同系物多肽和编码phoH同源多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用phoH同源多肽筛选抗菌化合物的方法。
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公开(公告)号:US5948642A
公开(公告)日:1999-09-07
申请号:US923738
申请日:1997-09-02
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号: G01N33/50 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/44 , A61K38/55 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/31 , C07K16/12 , C12N1/00 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/88 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/53 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/44 , C12R1/445 , G01N33/15 , G01N33/53 , G01N33/569 , G01N33/573 , C07H21/04 , C12N9/10
CPC分类号: C12N9/0006 , C07K14/31 , C12N9/00 , C12N9/1205 , C12N9/88 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要: The invention provides DNA strand resolution polypeptides and DNA (RNA) encoding DNA strand resolution polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DNA strand resolution polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了DNA链分解多肽和编码DNA链拆分多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用DNA链分解多肽筛选抗菌化合物的方法。
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