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    IOL WITH VARYING CORRECTION OF CHROMATIC ABERRATION
    41.
    发明申请
    IOL WITH VARYING CORRECTION OF CHROMATIC ABERRATION 有权
    IOL与变色修正色素脱落

    公开(公告)号：US20100312337A1

    公开(公告)日：2010-12-09

    申请号：US12780381

    申请日：2010-05-14

    申请人： Xiaoxiao Zhang ,  Costin Eugene Curatu ,  Krishnakumar Venkateswaran ,  Daniel Robert Carson ,  Mutlu Karakelle ,  Xin Hong ,  Yueai Liu

    发明人： Xiaoxiao Zhang ,  Costin Eugene Curatu ,  Krishnakumar Venkateswaran ,  Daniel Robert Carson ,  Mutlu Karakelle ,  Xin Hong ,  Yueai Liu

    IPC分类号： A61F2/16 ,  G02C7/10

    CPC分类号： A61F2/1654 ,  A61F2/1613 ,  G02C7/041 ,  G02C2202/20 ,  G02C2202/22

    摘要： An ophthalmic lens includes an optical filter operable to filter out at least visible light having a wavelength less than 450 nm. The lens also includes a first diffractive structure adapted to produce a focus for visible light in a first wavelength range above 550 nm and to reduce longitudinal chromatic aberration to less than one diopter for incoming visible light in the first wavelength range. The lens also includes a second diffractive structure outside the first diffractive structure in a radial direction and adapted to produce a focus for visible light in a second wavelength range between 450 nm and 550 nm. The second diffractive structure is also adapted to reduce longitudinal chromatic aberration for incoming visible light in the second wavelength range to less than one diopter while allowing longitudinal chromatic aberration in the first wavelength range in an amount greater than the first diffractive structure.

    摘要翻译： 一种眼科镜片包括可用于过滤掉至少具有小于450nm的波长的可见光的滤光器。 透镜还包括第一衍射结构，其适于产生在550nm以上的第一波长范围内的可见光的聚焦，并且将纵向色差减小到在第一波长范围内的入射可见光的小于一个屈光度。 透镜还包括在径向上的第一衍射结构外部的第二衍射结构，并且适于产生在450nm和550nm之间的第二波长范围内的可见光的焦点。 第二衍射结构还适于将在第二波长范围内的入射可见光的纵向色差减小到小于一个屈光度，同时允许第一波长范围内的纵向色差大于第一衍射结构的量。

    Accommodative IOL with Toric Optic and Extended Depth of Focus
    44.
    发明申请
    Accommodative IOL with Toric Optic and Extended Depth of Focus 审中-公开
    适应性IOL与Toric Optic和扩展的焦点深度

    公开(公告)号：US20100016965A1

    公开(公告)日：2010-01-21

    申请号：US12503307

    申请日：2009-07-15

    申请人： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Myoung-Taek Choi ,  Yan Zhang ,  Son Tran

    发明人： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Myoung-Taek Choi ,  Yan Zhang ,  Son Tran

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1613 ,  A61F2/1629 ,  A61F2/1645 ,  A61F2/1648 ,  G02C7/088

    摘要： In one aspect, the present invention provides an intraocular lens (IOL), which comprises at least two optics disposed in tandem along an optical axis, and an accommodative mechanism that is coupled to at least one of the optics and is adapted to adjust a combined optical power of the optics in response to natural accommodative forces of an eye in which the optics are implanted so as to provide accommodation. At least one of the optics has a surface characterized by a first refractive region, a second refractive region and transition region therebetween, where an optical phase shift of incident light having a design wavelength (e.g., 550 nm) across the transition region corresponds to a non-integer fraction of that wavelength.

    摘要翻译： 在一个方面，本发明提供了一种眼内透镜（IOL），其包括沿着光轴串联设置的至少两个光学器件，以及调节机构，其耦合到所述光学器件中的至少一个并且适于调整组合 响应于眼睛的自然调节力，光学器件的光学功率，其中植入光学器件以提供适应。 至少一个光学元件具有由第一折射区域，第二折射区域和它们之间的过渡区域表征的表面，其中穿过过渡区域的具有设计波长（例如，550nm）的入射光的光学相移对应于 该波长的非整数分数。

    NON-INVASIVE POWER ADJUSTABLE INTRAOCULAR LENS
    45.
    发明申请
    NON-INVASIVE POWER ADJUSTABLE INTRAOCULAR LENS 有权
    非入射功率可调节内窥镜

    公开(公告)号：US20090281620A1

    公开(公告)日：2009-11-12

    申请号：US12434237

    申请日：2009-05-01

    申请人： Alex Sacharoff ,  Mutlu Karakelle

    发明人： Alex Sacharoff ,  Mutlu Karakelle

    IPC分类号： A61F2/16 ,  A61F2/14

    CPC分类号： A61F2/1635 ,  A61F2/1618 ,  A61F9/008 ,  A61F9/00834 ,  A61F2009/0087 ,  A61F2009/0088 ,  A61F2250/001 ,  A61F2250/0071

    摘要： An improved multifocal design for an ocular implant is provided. This ocular implant includes an intraocular lens (IOL) and a number of haptics. The IOL passes optical energy. A microstructure within the IOL places the IOL under tension. The microstructure is operable to be broken in a controlled manner to release tension in the IOL and reshape the IOL. This may be done at any time post operatively and in conjunction with wavefront aberrometry to provide improved results. The haptics mechanically couple to the IOL in order to position and secure the IOL within the eye.

    摘要翻译： 提供了用于眼部植入物的改进的多焦点设计。 这种眼部植入物包括眼内透镜（IOL）和许多触觉。 IOL传递光能。 IOL中的微结构使IOL处于张力下。 微结构可操作地以受控的方式破碎以释放IOL中的张力并重塑IOL。 这可以在手术后的任何时间并结合波前像差测量来完成，以提供改进的结果。 触觉件机械地耦合到IOL以便将眼睛中的IOL定位和固定。

    COATED MEDICAL IMPLANTS AND LENSES
    46.
    发明申请
    COATED MEDICAL IMPLANTS AND LENSES 审中-公开
    涂层医用植绒和镜片

    公开(公告)号：US20080208334A1

    公开(公告)日：2008-08-28

    申请号：US12038030

    申请日：2008-02-27

    申请人： David L. Jinkerson ,  Mutlu Karakelle

    发明人： David L. Jinkerson ,  Mutlu Karakelle

    IPC分类号： A61F2/16 ,  A61F2/02

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10

    摘要： Coated medical implants have an implant body configured for securing in or adjacent to body tissue of a patient. The implant body has an implant surface and a coating is formed on at least a portion of the implant surface. The coating includes a coating outer surface of a first chemical component that is chemically bonded to a carboxylate functionality of a second chemical component. The second chemical component is immobilized by amide linkage to an underlying third chemical component that is plasma coated directly onto implant body surfaces. The coating either inhibits or prevents the adhesion of protein and/or cellular proliferation or may be a non-fouling coating.

    摘要翻译： 涂覆的医疗植入物具有构造成用于固定在患者身体组织中或邻近患者身体组织的植入体。 植入体具有植入物表面，并且在植入物表面的至少一部分上形成涂层。 涂层包括化学键合到第二化学组分的羧酸官能团的第一化学组分的涂层外表面。 第二种化学成分通过酰胺键固定在下面的第三种化学成分上，其等离子体涂覆在植入体表面上。 该涂层可抑制或防止蛋白质和/或细胞增殖的粘附，或者可以是非结垢的涂层。

    High refractive index ophthalmic lens materials
    49.
    发明授权
    High refractive index ophthalmic lens materials 失效
    高折射率眼科镜片材料

    公开(公告)号：US5693095A

    公开(公告)日：1997-12-02

    申请号：US739245

    申请日：1996-10-29

    申请人： Charles Freeman ,  David L. Jinkerson ,  Mutlu Karakelle ,  Albert R. LeBoeuf

    发明人： Charles Freeman ,  David L. Jinkerson ,  Mutlu Karakelle ,  Albert R. LeBoeuf

    IPC分类号： A61L27/00 ,  A61L27/16 ,  C08F2/44 ,  C08F220/10 ,  C08F220/16 ,  C08F220/18 ,  C08F220/30 ,  C08F220/34 ,  C08F220/38 ,  G02B1/04 ,  A61F2/16 ,  C08F26/06 ,  G02C7/04

    CPC分类号： A61F2/16 ,  A61L27/16 ,  C08F220/18 ,  C08F220/30 ,  G02B1/043 ,  A61L2430/16

    摘要： Improved soft, foldable acrylic lens materials which are particularly suited for use as IOLs, but which are also useful as other ophthalmic devices, such as contact lenses, keratoprostheses, and corneal rings or inlays, are disclosed. These materials contain only two principal components: one aryl acrylic hydrophobic monomer and one hydrophilic monomer. The materials of the present invention are copolymers comprising at least about 90% by weight of the two principal monomeric components; provided that the amount of the hydrophilic component is not greater than that of the aryl acrylic hydrophobic component. The remainder of the material comprises up to 10% by weight of one or more additional components, such as cross-linking, UV-light absorbing, and blue-light absorbing components. The aryl acrylic hydrophobic monomers suitable for use in the materials of the present invention have the formula ##STR1## wherein: X is H or CH.sub.3 ; m is 0-6; Y is nothing, O, S, or NR, wherein R is H, CH.sub.3, C.sub.n H.sub.2n+1 (n=1-10), iso-OC.sub.3 H.sub.7, C.sub.6 H.sub.5, or CH.sub.2 C.sub.6 H.sub.5 ; and Ar is any aromatic ring which can be unsubstituted or substituted with H, CH.sub.3, C.sub.2 H.sub.5, n-C.sub.3 H.sub.7, iso-C.sub.3 H.sub.7, OCH.sub.3, C.sub.6 H.sub.11, Cl, Br, C.sub.6 H.sub.5, or CH.sub.2 C.sub.6 H.sub.5.

    摘要翻译： 公开了改进的柔软的，可折叠的丙烯酸类镜片材料，其特别适合用作IOL，但也可用作其它眼科装置，例如隐形眼镜，角膜假体和角膜环或嵌体。 这些材料仅含有两种主要成分：一种芳基丙烯酸疏水单体和一种亲水单体。 本发明的材料是包含至少约90重量％的两种主要单体组分的共聚物; 只要亲水组分的量不大于芳基丙烯酸疏水组分的量。 剩余的材料包含至多10重量％的一种或多种另外的组分，例如交联，UV光吸收和蓝光吸收组分。 适用于本发明材料的芳基丙烯酸类疏水性单体具有下式：其中：X为H或CH 3; m为0-6; Y不为O，S或NR，其中R为H，CH 3，C n H 2n + 1（n = 1-10），异OC 3 H 7，C 6 H 5或CH 2 C 6 H 5; Ar可以是未被取代或被H，CH 3，C 2 H 5，n-C 3 H 7，异-C 3 H 7，OCH 3，C 6 H 11，Cl，Br，C 6 H 5或CH 2 C 6 H 5取代的任何芳香环。