摘要:
Raman amplifier systems and methods with an integrated Optical Time Domain Reflectometer (OTDR) for integrated testing functionality include an amplifier system, an OTDR and telemetry subsystem, and a method of operation. The OTDR and telemetry subsystem is configured to operate in an OTDR mode when coupled to a line in port and to operate in a telemetry mode when coupled to a line out port. The OTDR and telemetry subsystem enables on-demand fiber testing while also operating as a telemetry channel that is both a redundant optical service channel (OSC) and provides a mechanism to monitor Raman gain over time. The OTDR and telemetry subsystem minimizes cost and space by sharing major optical and electrical components between the integrated OTDR and other functions on the Raman amplifier.
摘要:
Raman amplifier systems and methods with an integrated Optical Time Domain Reflectometer (OTDR) for integrated testing functionality include an amplifier system, an OTDR and telemetry subsystem, and a method of operation. The OTDR and telemetry subsystem is configured to operate in an OTDR mode when coupled to a line in port and to operate in a telemetry mode when coupled to a line out port. The OTDR and telemetry subsystem enables on-demand fiber testing while also operating as a telemetry channel that is both a redundant optical service channel (OSC) and provides a mechanism to monitor Raman gain over time. The OTDR and telemetry subsystem minimizes cost and space by sharing major optical and electrical components between the integrated OTDR and other functions on the Raman amplifier.
摘要:
Provided is an anti-angiogenic fusion protein, which comprises a vascular endothelial cell growth inhibitor (VEGI) or variant thereof, and other polypeptide such as IgG Fc. The fusion protein optionally comprises a linker. The fusion protein can induce the apoptosis of endothelial cells and inhibit the growtth of endothelial cells, so as to be used for treating tumor. Also provided are a pharmaceutical composition and use of the fusion protein.
摘要:
The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要:
The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要:
A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell. In this embodiment, the extension product can be preserved under appropriate conditions for an extended time before the completion of the quantification step.
摘要:
An optical communication device, and related method, are provided for reducing ripple in WDM systems. In particular, the optical communication device includes a dynamic gain equalization (DGE) circuit is coupled to an optical communication path carrying the WDM optical signals. The DGE circuit adjusts the powers associated with each channel on a channel-by-channel basis so that the WDM optical signal has a desired power spectrum. The DGE is controlled in response to sense signals generated by an optical performance monitoring (OPM) circuit located downstream from the DGE or substantially co-located with the DGE. The OPM monitors the WDM spectrum for optical signal power variations and outputs the sense signal when the variations fall outside a given tolerance. Typically, one DGE is associated with a group of concatenated amplifiers so that multiple DGEs are provided in a system having many groups of such amplifiers. Likewise, multiple OPMs are provided in such systems, each corresponding to a respective DGE, so that ripple can be reduced and desired WDM optical signal powers can be achieved in the WDM system.