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    Expandable fluoropolymer device and method of making
    44.
    发明授权
    Expandable fluoropolymer device and method of making 有权

    公开(公告)号：US07637886B2

    公开(公告)日：2009-12-29

    申请号：US10131396

    申请日：2002-04-22

    申请人： Steve A. Herweck ,  Peter H. Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter H. Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61M29/00

    CPC分类号： A61L29/041 ,  A61M25/10 ,  B29C47/00 ,  B29C47/0023 ,  B29C55/24 ,  B29C2049/465 ,  B29K2027/18 ,  B29L2022/022 ,  B29L2031/753 ,  B32B2305/026 ,  Y10T428/1376 ,  C08L27/18

    摘要： A radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material is described. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device. In addition, the microstructure of nodes interconnected by fibrils provides at least one predetermined flow rate of fluid therethrough over a range of fluid pressures.

    Implantable barrier device
    45.
    发明申请
    Implantable barrier device 有权
    植入式屏障装置

    公开(公告)号：US20080206305A1

    公开(公告)日：2008-08-28

    申请号：US12075223

    申请日：2008-03-10

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61F2/00 ,  A61K47/12

    CPC分类号： A61L31/10 ,  A61F2/0063 ,  A61F2/06 ,  A61F2250/0067 ,  A61L31/145

    摘要： A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 屏障装置由能够表现出抗炎性质，非炎症性质和/或粘合限制性能的屏障组分形成，并且对损伤的组织产生调节的愈合作用。 阻隔组分可以是至少部分由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 阻挡装置可以具有锚定位置以在阻挡装置上提供与锚定机构相接合的区域。 锚固位置可以包括开口和/或锚定元件。 阻挡装置还可以包括为屏障部件提供附加强度的桁架结构。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Multi-stage prosthesis
    46.
    发明授权
    Multi-stage prosthesis 有权
    多期假体

    公开(公告)号：US06416537B1

    公开(公告)日：2002-07-09

    申请号：US09604382

    申请日：2000-06-27

    申请人： Paul Martakos ,  Peter Gingras ,  Theodore Karwoski ,  Steve A. Herweck

    发明人： Paul Martakos ,  Peter Gingras ,  Theodore Karwoski ,  Steve A. Herweck

    IPC分类号： A61F206

    CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/105 ,  A61F2/2412 ,  A61F2/88 ,  A61F2002/072 ,  A61F2240/001 ,  A61L27/16 ,  A61L27/34 ,  A61L27/507 ,  C08L27/18

    摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.

    摘要翻译： 公开了适合用作血管​​移植假体的多孔管及其制造方法。 它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。 本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。 发现PTFE壁具有不同孔隙率的径向区域。

    Expandable shielded vessel support
    47.
    发明授权
    Expandable shielded vessel support 有权
    可扩展屏蔽容器支架

    公开(公告)号：US06270523B1

    公开(公告)日：2001-08-07

    申请号：US09419467

    申请日：1999-10-15

    申请人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61F206

    CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/105 ,  A61F2/88 ,  A61F2002/072 ,  A61F2240/001 ,  A61L31/04 ,  A61L31/10 ,  C08L27/18 ,  Y10S623/901

    摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g., polytetraeluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the-stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.

    摘要翻译： 径向可扩展的支撑体被包围在茧内。 在优选的结构中，支撑件是支架，并且聚合物材料管例如聚多异氰酸乙烯（PTFE）穿过支架主体的内部并且在其上自我转过支架以形成袖带。 然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。 在一个实施例中，管的端部在折叠回支架之前膨胀。 成为成品的外表面的端部因此获得更大程度的孔隙率。 中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。 支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。 空间或孔被内聚合物层和外聚合物层覆盖或桥接。 可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。 这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。 在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。 一根管子被套在后面，另一根管子覆盖着袖口支架。 在该实施例中，管的厚度和孔隙度可能基本上不同。 例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。