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公开(公告)号：US09249404B2
公开(公告)日：2016-02-02
申请号：US11921399
申请日：2006-05-30
申请人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
发明人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
CPC分类号： C12N9/6432 , C12Y304/21006
摘要： The present invention relates to modified cDNA sequences coding for human Factor X and their derivatives with improved stability and modified activation sequences, recombinant expression vectors containing such cDNA sequences, and host cells transformed with such recombinant expression vectors. The invention also relates to recombinant factor X polypeptides and derivatives which have biological activities of the unmodified wild type protein but with improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA.
摘要翻译： 本发明涉及编码具有改善的稳定性和修饰的活化序列的人因子X及其衍生物的修饰cDNA序列，含有此类cDNA序列的重组表达载体和用这些重组表达载体转化的宿主细胞。 本发明还涉及具有未修饰的野生型蛋白的生物活性但具有改进的稳定性的重组因子X多肽和衍生物，以及用于制备这些重组蛋白及其衍生物的方法。 本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA。
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42.发明申请Modified Coagulation Factor VIII With Enhanced Stability and Its Derivatives 审中-公开改性凝血因子VIII具有增强的稳定性及其衍生物公开(公告)号：US20110124565A1
公开(公告)日：2011-05-26
申请号：US11918280
申请日：2006-04-10
申请人： Hans-Peter Hauser , Thomas Weimer , Jean-Luc Plantier , Marie-Hélène Rodriguez , Claude Négrier
发明人： Hans-Peter Hauser , Thomas Weimer , Jean-Luc Plantier , Marie-Hélène Rodriguez , Claude Négrier
IPC分类号： A61K38/37 , C07K14/755 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/00 , A61K31/7088 , A61P7/04
CPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to modified nucleic acid sequences coding for coagulation factors, in particular human Factor VIII and their derivatives with improved stability, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises modified DNA sequences.
摘要翻译： 本发明涉及编码凝血因子的修饰的核酸序列，特别是具有改善的稳定性的人因子VIII及其衍生物，含有此类核酸序列的重组表达载体，用这种重组表达载体转化的宿主细胞，重组多肽和衍生物 具有未经修饰的野生型蛋白质的生物活性，但具有改进的稳定性和制备这种重组蛋白质及其衍生物的方法。 本发明还涵盖用于人基因治疗的转移载体，其包含修饰的DNA序列。
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公开(公告)号：US20090130060A1
公开(公告)日：2009-05-21
申请号：US11632552
申请日：2005-08-10
申请人： Thomas Weimer , Stefan Schulte , Kay Hofmann , Hans-Peter Hauser
发明人： Thomas Weimer , Stefan Schulte , Kay Hofmann , Hans-Peter Hauser
IPC分类号： A61K35/74 , C07K1/00 , C07K14/00 , C12N9/50 , C12N15/11 , C12N15/00 , C12N1/21 , C12P21/04 , A61K38/16 , A61K31/7088
CPC分类号： C12N15/62 , C12N9/6424
摘要： The present invention relates to modified cDNA sequences coding for vitamin K-dependent polypeptides, in particular human Factor VII, human Factor VIIa, human Factor IX and human protein C and their derivatives with improved stability and extended plasma half life, recombinant expression vectors containing such cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.
摘要翻译： 本发明涉及编码维生素K依赖多肽，特别是人因子VII，人因子VIIa，人因子IX和人蛋白C及其衍生物的修饰cDNA序列，其具有改善的稳定性和延长的血浆半衰期，含有这样的重组表达载体 cDNA序列，用这种重组表达载体转化的宿主细胞，确实具有未修饰的野生型蛋白质的生物活性但具有改进的稳定性的生物活性的重组多肽和衍生物，以及制备这些重组蛋白及其衍生物的方法。 本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。
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44.发明申请Use of plasma proteins concentrates containing VWF with a high proportion of high molecular weight multimers 有权使用含有高比例高分子量多聚体的VWF的血浆蛋白浓缩物公开(公告)号：US20050282735A1
公开(公告)日：2005-12-22
申请号：US11121046
申请日：2005-05-04
申请人： Olaf Walter , Hans-Peter Hauser
发明人： Olaf Walter , Hans-Peter Hauser
摘要： Use of plasma proteins concentrates containing VWF with a high proportion of high molecular weight multimers prevents a bleeding diathesis and reduces pre-, peri- and postoperative blood loss in acquired Von Willebrand syndromes such as in cardiovascular diseases requiring surgical procedures, especially those requiring extracorporeal circulation.
摘要翻译： 使用含有高比例高分子量多聚体的VWF的血浆蛋白浓缩物可以预防出血素质，并减少获得性Von Willebrand综合征的前期，术后和术后失血量，例如需要外科手术的心血管疾病，特别是需要体外循环的心血管疾病 。
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公开(公告)号：US06974866B2
公开(公告)日：2005-12-13
申请号：US10357400
申请日：2003-02-04
申请人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gürtler , Josef Eberle , Lazare Kaptue , Léopold Achenqui Zekeng
发明人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gürtler , Josef Eberle , Lazare Kaptue , Léopold Achenqui Zekeng
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S530/812
摘要： A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.
摘要翻译： 公开了一种新型的HIV型O免疫缺陷病毒，其命名为MVP-2901/94，并且已经在欧洲的动物细胞培养物集合（ECACC）V 950121601中保藏。可从病毒获得的特征性抗原 并且还可以用于检测与免疫缺陷病相关的抗逆转录病毒的抗体，以及病毒的部分DNA和氨基酸序列。
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公开(公告)号：US20050186660A1
公开(公告)日：2005-08-25
申请号：US11055622
申请日：2005-02-11
申请人： Harald Althaus , Hans-Peter Hauser
发明人： Harald Althaus , Hans-Peter Hauser
IPC分类号： C12N15/09 , A61K9/08 , A61K38/00 , A61K38/23 , A61K39/395 , A61K47/28 , A61K47/42 , A61P3/14 , A61P5/22 , A61P35/04 , C07J9/00 , C07K14/585 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/16 , C12P21/02 , C12P21/08 , C07H21/04
CPC分类号： C07K14/585 , A61K38/00 , C07K2319/00 , Y10S435/967
摘要： The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.
摘要翻译： 本发明涉及人类降钙素原及其制备和应用。 具体地，描述了一种制备人降钙素原的方法，其中将编码包含人降钙素原的氨基酸序列的多肽的基因插入载体中; 用含该基因的载体转化宿主生物; 并分离由宿主生物表达的多肽。 此外，描述了根据本发明的多肽，特别是作为药物和诊断剂的用途。
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公开(公告)号：US06773915B2
公开(公告)日：2004-08-10
申请号：US10326090
申请日：2002-12-23
IPC分类号： C12N502
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译： 公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91，并且已经在欧洲动物细胞培养物收集库（ECACC）V 920 52 318下保藏。可从其中获得的特征性抗原，其中 可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，以及病毒的DNA和氨基酸序列也被公开。
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48.发明授权公开(公告)号：US06414116B1
公开(公告)日：2002-07-02
申请号：US09219797
申请日：1998-12-23
IPC分类号： A61K3925
CPC分类号： C07K14/005 , C12N2710/16722 , Y10S435/81 , Y10S435/975
摘要： The present invention relates to immunoreactive peptides that are homologous with the region encompassing amino acid positions 450 to 655 of glycoprotein II of varicella zoster virus. In this context, preference is given to those peptides corresponding to segments of amino acids 505 to 647, 517 to 597, 535 to 584 or 545 to 582. The immunoreactive peptides are useful for methods of diagnosing varicella zoster virus infection.
摘要翻译： 本发明涉及与包含水痘带状疱疹病毒的糖蛋白II的氨基酸位置450至655的区域同源的免疫反应性肽。 在本文中，优选对应于氨基酸505至647,517至597,535至584或545至582的片段的那些肽。免疫反应性肽可用于诊断水痘带状疱疹病毒感染的方法。
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49.发明授权Varicella zoster virus (VZV) immunoreactive protein VP26 and its diagnostic use 失效水痘带状疱疹病毒（VZV）免疫反应蛋白VP26及其诊断用途公开(公告)号：US06258363B1
公开(公告)日：2001-07-10
申请号：US09219337
申请日：1998-12-23
IPC分类号： A61K39245
CPC分类号： C07K14/005 , C12N2710/16722
摘要： Varicella zoster virus (VZV) immunoreactive protein VP26 and its diagnostic use are described. The invention relates to immunoreactive peptides which are homologous with the region of amino acid positions 12 to 235 of the varicella zoster virus protein VP26, to nucleic acids which encode these peptides and to the use of the peptides or nucleic acids for diagnosing an infection with varicella zoster virus.
摘要翻译： 描述了水痘带状疱疹病毒（VZV）免疫反应蛋白VP26及其诊断用途。 本发明涉及与水痘带状疱疹病毒蛋白VP26的氨基酸位置12至235的区域同源的免疫反应性肽与编码这些肽的核酸以及肽或核酸用于诊断水痘感染的用途 带状疱疹病毒
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公开(公告)号：US6162631A
公开(公告)日：2000-12-19
申请号：US989493
申请日：1997-12-12
申请人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gurtler , Josef Eberle , Lazare Kaptue , Leopold Achengui Zekeng
发明人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gurtler , Josef Eberle , Lazare Kaptue , Leopold Achengui Zekeng
IPC分类号： G01N33/569 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C12N7/00 , C12N15/00 , C12N15/09 , C12N15/49 , C12Q1/68 , C12Q1/70 , C12R1/92 , G09B19/00
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S436/828 , Y10S530/812
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 95012601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.
摘要翻译： 公开了具有命名为MVP-2901/94的新型免疫缺陷病毒，其已经在欧洲动物细胞培养物库（ECACC）V 95012601下保藏。可以从病毒获得的特征性抗原 用于检测与免疫缺陷病相关的逆转录病毒的抗体也被公开，病毒的部分DNA和氨基酸序列也被公开。
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