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公开(公告)号：US20210254131A1
公开(公告)日：2021-08-19
申请号：US17238682
申请日：2021-04-23
Applicant: President and Fellows of Harvard College
Inventor： George M. Church , Jehyuk Lee , Daniel Levner , Michael Super
IPC: C12Q1/6806 , C12Q1/6874 , C12Q1/6869 , C12Q1/6844 , C12P19/34
Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
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公开(公告)号：US11034744B2
公开(公告)日：2021-06-15
申请号：US16669805
申请日：2019-10-31
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Alexander L. Watters , Donald E. Ingber , Mark J. Cartwright , Michael Super , Martin Rottman , Evangelia Murray , Brendon Dusel
IPC: C07K14/47 , G01N33/68 , G01N33/569 , A61K47/42 , A61K38/00
Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
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公开(公告)号：US11021737B2
公开(公告)日：2021-06-01
申请号：US16941585
申请日：2020-07-29
Applicant: President and Fellows of Harvard College
Inventor： George M. Church , Je-hyuk Lee , Daniel Levner , Michael Super
IPC: C12Q1/68 , C12P19/34 , C12Q1/6806 , C12Q1/6874 , C12Q1/6869 , C12Q1/6844
Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
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公开(公告)号：US10982100B2
公开(公告)日：2021-04-20
申请号：US16780792
申请日：2020-02-03
Applicant: President and Fellows of Harvard College
Inventor： Joanna Aizenberg , Benjamin Hatton , Donald Ingber , Michael Super , Tak Sing Wong
IPC: C09D5/16 , A61L15/24 , A61L15/34 , A61L15/42 , A61L15/46 , A61L27/28 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/06 , F15D1/02 , F15D1/10 , B05D5/08
Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.
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公开(公告)号：US10551379B2
公开(公告)日：2020-02-04
申请号：US14766575
申请日：2014-03-14
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Michael Super , Mark J. Cartwright , Martin M. Rottman , Julie A. Tomolonis
IPC: G01N33/50 , G01N33/569
Abstract: Methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample are disclosed. In particular, the methods, compositions and kits described herein can be used for pretreatment of target-binding agents with a blocking agent to reduce non-target binding in a complex matrix (e.g., blood). Methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also disclosed.
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Patent Agency Ranking
公开(公告)号：US10526399B2
公开(公告)日：2020-01-07
申请号：US15415352
申请日：2017-01-25
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Michael Super , Jeffrey Charles Way , Mark J. Cartwright , Julia B. Berthet , Dinah R. Super , Martin Rottman , Alexander L. Watters
IPC: C07K16/12 , G01N33/543 , G01N33/569 , C07K14/42 , A61K47/68
Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.
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公开(公告)号：US10513546B2
公开(公告)日：2019-12-24
申请号：US15105298
申请日：2014-12-18
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Alexander L. Watters , Donald E. Ingber , Mark J. Cartwright , Michael Super , Martin Rottman , Evangelia Murray , Brendon Dusel
IPC: C07K14/47 , G01N33/569 , A61K47/42 , G01N33/68 , A61K38/00
Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
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公开(公告)号：US20190241938A1
公开(公告)日：2019-08-08
申请号：US16255920
申请日：2019-01-24
Applicant: President and Fellows of Harvard College
Inventor： Daniel Levner , Je-Hyuk Lee , George M. Church , Michael Super
IPC: C12Q1/6837 , C12Q1/6816 , C12Q1/6804
CPC classification number: C12Q1/6837 , C12Q1/6804 , C12Q1/6816 , G01N33/53 , G01N2458/10 , C12Q2535/122 , C12Q2537/143 , C12Q2563/107 , C12Q2563/179 , C12Q2565/514
Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
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公开(公告)号：US10357780B2
公开(公告)日：2019-07-23
申请号：US15522686
申请日：2015-10-27
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Joo Hun Kang , Donald E. Ingber , Michael Super
Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
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公开(公告)号：US09632085B2
公开(公告)日：2017-04-25
申请号：US14382043
申请日：2013-02-28
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Michael Super , Donald E. Ingber , Mark J. Cartwright , Alexander Watters , John Samuel Workman , Daniel Levner , Martin Marcus Rottman
IPC: G01N33/53 , G01N33/569 , C12Q1/18
CPC classification number: G01N33/56938 , C12Q1/18 , G01N33/56911 , G01N33/56916 , G01N2333/245 , G01N2333/31 , G01N2500/10
Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.
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