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公开(公告)号：US20200271395A1
公开(公告)日：2020-08-27
申请号：US16629899
申请日：2018-07-10
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Jonathan Grinham , Martin Bechthold , Salmaan Craig , Donald Ingber
Abstract: A radiant cooling device comprises at least one fluidic layer including one or more micro-channel liquid-circuits and at least one structural layer coupled to the at least one fluidic layer. The device further includes a plurality of folds such that the device has a three-dimensional surface geometry having a plurality of inclined surfaces.
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公开(公告)号：US10982100B2
公开(公告)日：2021-04-20
申请号：US16780792
申请日：2020-02-03
Applicant: President and Fellows of Harvard College
Inventor： Joanna Aizenberg , Benjamin Hatton , Donald Ingber , Michael Super , Tak Sing Wong
IPC: C09D5/16 , A61L15/24 , A61L15/34 , A61L15/42 , A61L15/46 , A61L27/28 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/06 , F15D1/02 , F15D1/10 , B05D5/08
Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.
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3.发明申请MODIFICATION OF SURFACES FOR SIMULTANEOUS REPELLENCY AND TARGETED BINDING OF DESIRED MOIETIES 审中-公开修改同时代表的表面和有针对性的绑定公开(公告)号：US20150173883A1
公开(公告)日：2015-06-25
申请号：US14415918
申请日：2013-07-12
Applicant: President and Fellows of Harvard College
Inventor： Donald Ingber , Michael Super , Daniel C. Leslie , Tohid Didar , Alexander L. Watters , Julia Bellows Berthet , Anna Waterhouse
CPC classification number: A61F2/01 , A61B5/00 , A61B5/0071 , A61B5/0075 , A61B5/1468 , A61L29/085 , A61L29/16 , A61L31/028 , A61L31/08 , A61L31/14 , A61L2300/252 , A61L2300/256 , A61L2300/42 , A61L2300/452 , A61L2400/18 , A61L2420/00 , A61M27/002 , A61M27/006 , C09D5/1662 , C09D5/1687 , C09D5/1693 , G01N33/56916 , G01N33/56938 , Y10T428/31663 , C08L83/00
Abstract: Articles, methods of making, and uses for modifying surfaces for simultaneously providing repellency and selective binding of desired moieties are disclosed. The repellant surfaces comprise a substrate and a lubricating layer immobilized over the substrate surface having a lubricating liquid having an affinity with the substrate. The substrate and the lubricating liquid are attracted to each other together by non-covalent attractive forces. The repellent surface further includes a binding group extending over the surface of the lubricating layer and the binding group has an affinity with a target moiety. The lubricating layer and the substrate form a slippery or repellent surface configured and arranged for contact with a material that is immiscible with the lubricating liquid and the immiscible material contains the target moiety.
Abstract translation: 公开了制备的方法，以及用于改变表面以同时提供所需部分的排斥性和选择性结合的用途。 排斥表面包括固定在基材表面上的基材和润滑层，其具有与基材具有亲和性的润滑液体。 基体和润滑液通过非共价吸引力相互吸引。 驱避表面还包括在润滑层的表面上延伸的结合基团，并且结合基团与靶部分具有亲和性。 润滑层和基底形成滑动或驱除表面，其被构造和布置成与与润滑液体不混溶的材料接触并且不混溶材料含有目标部分。
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Patent Agency Ranking
公开(公告)号：US20230355540A1
公开(公告)日：2023-11-09
申请号：US18029028
申请日：2021-09-28
Inventor： Daniel Beard , Donald Ingber , Oktay Uzun , Frank Bobe
CPC classification number: A61K9/5153 , A61K45/06 , A61K9/0019 , A61K31/4418 , A61K31/21 , A61P9/10 , B82Y5/00
Abstract: The present invention relates to a shear-activated nanotherapeutic (SA-NT) for use in treating stroke by increasing blood supply to the brain via collateral vessels, wherein the SA-NT comprises an aggregate comprising a plurality of nanoparticles, the aggregate further comprising one or more vasodilating agents or pharmaceutically acceptable salts thereof; wherein the aggregate is configured to disaggregate above a predetermined shear stress.
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公开(公告)号：US10550272B2
公开(公告)日：2020-02-04
申请号：US15944619
申请日：2018-04-03
Applicant: President and Fellows of Harvard College
Inventor： Joanna Aizenberg , Benjamin Hatton , Donald Ingber , Michael Super , Tak Sing Wong
IPC: C09D5/16 , A61L15/24 , A61L15/34 , A61L15/42 , A61L15/46 , A61L27/28 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/06 , F15D1/02 , F15D1/10 , B05D5/08
Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.
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公开(公告)号：US10245355B2
公开(公告)日：2019-04-02
申请号：US14904399
申请日：2014-07-10
Applicant: President and Fellows of Harvard College
Inventor： Donald Ingber , Daniel C. Leslie , Michael Super , Alexander L. Watters , Anna Waterhouse
IPC: B05D5/08 , B05D5/12 , A61L27/34 , A61L29/14 , A61L31/10 , A61L33/00 , A61L31/08 , A61L29/08 , C09D5/16 , A61L31/14
Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.
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公开(公告)号：US20140342954A1
公开(公告)日：2014-11-20
申请号：US14371728
申请日：2013-01-10
Applicant: President and Fellows of Harvard College
Inventor： Donald Ingber , Daniel C. Leslie , Alexander L. Watters , Michael Super , Joanna Aizenberg , Michael Aizenberg , Philseok Kim , Anna Waterhouse
IPC: A61L33/04
CPC classification number: A61L33/04 , A61L29/06 , A61L29/08 , A61L29/14 , A61L33/0041 , A61L33/0094 , A61L2400/18 , A61L2420/02 , A61L2420/06 , B05D1/60 , B05D3/107 , B05D5/086 , B05D7/02 , C09D5/1656 , C09D5/1693 , C08L83/04
Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has a head group that is covalently linked to, or adsorbed onto, the surface and a functional group. The functional group of the treated surface has an affinity for a lubricating layer, which is applied to the treated surface. The anchoring layer and replenishable lubricating layer are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.
Abstract translation: 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有共价连接或吸附在表面上的头基和官能团。 经处理的表面的官能团对施加到被处理表面的润滑层具有亲和性。 锚定层和可补充润滑层通过非共价吸引力保持在一起。 这些层一起形成一个超疏水滑表面，排斥某些不混溶液体，并防止其中所含组分的吸附，凝结和表面结垢。
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公开(公告)号：US11788800B2
公开(公告)日：2023-10-17
申请号：US16629899
申请日：2018-07-10
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Jonathan Grinham , Martin Bechthold , Salmaan Craig , Donald Ingber
CPC classification number: F28F3/12 , F28D9/0025 , F28D9/0087 , F28F21/065 , F28F2210/02 , F28F2260/02
Abstract: A radiant cooling device comprises at least one fluidic layer including one or more micro-channel liquid-circuits and at least one structural layer coupled to the at least one fluidic layer. The device further includes a plurality of folds such that the device has a three-dimensional surface geometry having a plurality of inclined surfaces.
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