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公开(公告)号：US08543354B2
公开(公告)日：2013-09-24
申请号：US12914969
申请日：2010-10-28
申请人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
发明人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
IPC分类号： G06F17/18
CPC分类号： G01N33/66 , A61B5/0017 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B5/6849 , A61B5/7207
摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.
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公开(公告)号：US20130109942A1
公开(公告)日：2013-05-02
申请号：US13365406
申请日：2012-02-03
申请人： Ning Yang , Rebecca K. Gottlieb , Keith Nogueira , Xiaolong Li , Bradley Liang , Brian T. Kannard
发明人： Ning Yang , Rebecca K. Gottlieb , Keith Nogueira , Xiaolong Li , Bradley Liang , Brian T. Kannard
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14528 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7242 , A61B5/7275 , A61M5/1723 , F04C2270/0421
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
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公开(公告)号：US20110320166A1
公开(公告)日：2011-12-29
申请号：US12914969
申请日：2010-10-28
申请人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
发明人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
CPC分类号： G01N33/66 , A61B5/0017 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B5/6849 , A61B5/7207
摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.
摘要翻译： 公开了用于葡萄糖传感器信号稳定性分析的方法，装置等。 在某些示例性实施例中，可以获得响应于患者的血糖水平的至少一个传感器信号的一系列样本。 至少部分地基于一系列样本，可以确定至少一个度量以评估至少一个传感器信号对患者随着时间的血糖水平的响应性的变化的潜在趋势。 可以至少部分地基于评估潜在趋势的至少一个度量来评估至少一个传感器信号对患者的血糖水平的响应的可靠性。 本文公开了其它示例性实施例。
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公开(公告)号：US09008744B2
公开(公告)日：2015-04-14
申请号：US13102390
申请日：2011-05-06
申请人： Jefferson Rose , Ashwin K. Rao , Ning Yang , Chia-Hung Chiu , Ying Luo , Rebecca K. Gottlieb
发明人： Jefferson Rose , Ashwin K. Rao , Ning Yang , Chia-Hung Chiu , Ying Luo , Rebecca K. Gottlieb
IPC分类号： A61B5/05 , A61B5/1473 , A61B5/145 , G01N27/327
CPC分类号： A61B5/14735 , A61B5/14532 , G01N27/3272
摘要： Embodiments of the invention provide analyte sensors and sensor systems such as amperometric glucose sensors used in the management of diabetes as well as optimized methods for monitoring analytes using such sensors and sensor systems.
摘要翻译： 本发明的实施方案提供分析物传感器和传感器系统，例如用于糖尿病管理的电流葡萄糖传感器以及使用这种传感器和传感器系统监测分析物的优化方法。
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公开(公告)号：US20130109940A1
公开(公告)日：2013-05-02
申请号：US13282096
申请日：2011-10-26
申请人： Ning Yang , Rebecca K. Gottlieb , Keith Nogueira , Xiaolong Li , Bradley Liang
发明人： Ning Yang , Rebecca K. Gottlieb , Keith Nogueira , Xiaolong Li , Bradley Liang
IPC分类号： A61B5/1468
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6833 , A61B5/6849 , A61B5/7203 , A61B5/7239 , A61B5/725 , A61B5/7275 , A61M5/1723 , G06F19/00
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
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公开(公告)号：US20120197150A1
公开(公告)日：2012-08-02
申请号：US13017672
申请日：2011-01-31
申请人： Jian Cao , Christine Gale Kronich , David M. Fuss , Rebecca K. Gottlieb , Jeffrey L. Kehn , Paul Gordon Krause , Brian B. Lee , George Patras
发明人： Jian Cao , Christine Gale Kronich , David M. Fuss , Rebecca K. Gottlieb , Jeffrey L. Kehn , Paul Gordon Krause , Brian B. Lee , George Patras
IPC分类号： A61B5/0402
CPC分类号： A61B5/0432 , A61B5/6823
摘要： An external physiological monitor continuously senses and monitors cardiac function of a patient to allow detection of cardiac events and the recording of data and signals pre- and post-event. The monitor is connected to and suspended on the patient's body solely by the electrode assembly. Stored diagnostic data may be uplinked and evaluated by the patient's physician utilizing a programmer via a two-way telemetry link. An external patient activator may optionally allow the patient, or other care provider to manually activate the recording of diagnostic data.
摘要翻译： 外部生理监视器连续地感测和监视患者的心脏功能，以允许检测心脏事件以及事件之前和事件之后的数据和信号的记录。 显示器仅通过电极组件连接到患者身上并悬挂在患者身上。 存储的诊断数据可以由患者的医生通过双向遥测链路利用编程器进行上行链路和评估。 外部患者激活器可以可选地允许患者或其他护理提供者手动激活诊断数据的记录。
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公开(公告)号：US20110319734A1
公开(公告)日：2011-12-29
申请号：US13165061
申请日：2011-06-21
申请人： Rebecca K. Gottlieb , Chia-Hung Chiu , Meena Ramachandran , Nandita Dangui-Patel , Jefferson Rose , Ashwin K. Rao , Hsifu Wang , Ying Luo
发明人： Rebecca K. Gottlieb , Chia-Hung Chiu , Meena Ramachandran , Nandita Dangui-Patel , Jefferson Rose , Ashwin K. Rao , Hsifu Wang , Ying Luo
IPC分类号： A61B5/145
CPC分类号： A61B5/1486 , A61B5/0017 , A61B5/14503 , A61B5/14532 , A61B5/726 , C12Q1/001 , G01N27/307
摘要： Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译： 本发明的实施例提供了具有多个相关结构元件（例如包括工作，计数器和参考电极的传感器阵列）和被设计用于这种传感器的算法的电流分析物传感器。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。
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公开(公告)号：US20080300572A1
公开(公告)日：2008-12-04
申请号：US11757153
申请日：2007-06-01
申请人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
发明人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
IPC分类号： A61M37/00
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/411 , A61B5/7275 , A61M5/142 , A61M5/14244 , A61M5/172 , A61M2205/18 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2209/01 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device.
摘要翻译： 本文描述了用于流体输注系统的监视器装置及其操作，显示和数据处理特性。 监测装置的一个实施例用于具有胰岛素输注泵和连续葡萄糖传感器发射器的胰岛素输注系统中。 监视器装置被配置为无线床边监视器，其从诸如输液泵或传感器发射器的流体输注系统中的装置无线地接收状态数据。 监视器设备支持许多用户界面功能，警报/警报功能和图形显示功能，其中这些功能可提高监视器设备的整体操作和用户友好性。 例如，监视器设备可以生成状态图标，其图形地指示输注系统中的设备的可耗费的操作量的剩余时间（例如，电池充电，流体存储器容积，或校准或更换周期）。 监视器装置还可以基于由监视器装置接收的经验测量数据来估计被监视患者的生理特征的未来测量。
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公开(公告)号：US09215995B2
公开(公告)日：2015-12-22
申请号：US13165061
申请日：2011-06-21
申请人： Rebecca K. Gottlieb , Chia-Hung Chiu , Meena Ramachandran , Nandita Dangui-Patel , Jefferson Rose , Ashwin K. Rao , Hsifu Wang , Ying Luo
发明人： Rebecca K. Gottlieb , Chia-Hung Chiu , Meena Ramachandran , Nandita Dangui-Patel , Jefferson Rose , Ashwin K. Rao , Hsifu Wang , Ying Luo
CPC分类号： A61B5/1486 , A61B5/0017 , A61B5/14503 , A61B5/14532 , A61B5/726 , C12Q1/001 , G01N27/307
摘要： Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译： 本发明的实施例提供了具有多个相关结构元件（例如包括工作，计数器和参考电极的传感器阵列）和被设计用于这种传感器的算法的电流分析物传感器。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。
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公开(公告)号：US08882665B2
公开(公告)日：2014-11-11
申请号：US13282096
申请日：2011-10-26
申请人： Ning Yang , Rebecca K. Gottlieb , Keith Nogueira , Xiaolong Li , Bradley Liang
发明人： Ning Yang , Rebecca K. Gottlieb , Keith Nogueira , Xiaolong Li , Bradley Liang
IPC分类号： A61B5/00 , A61B5/145 , A61M5/172 , A61B5/1495 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6833 , A61B5/6849 , A61B5/7203 , A61B5/7239 , A61B5/725 , A61B5/7275 , A61M5/1723 , G06F19/00
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.
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