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    Methods and compositions for the detection of mucolipidosis IV mutations
    41.
    发明申请
    Methods and compositions for the detection of mucolipidosis IV mutations 审中-公开
    检测粘液脂肪病IV突变的方法和组成

    公开(公告)号：US20050153300A1

    公开(公告)日：2005-07-14

    申请号：US10754446

    申请日：2004-01-09

    申请人： Weimin Sun ,  Feras Hantash

    发明人： Weimin Sun ,  Feras Hantash

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16

    摘要： The present invention provides a simple high-throughput assay for detecting Mucolipidosis IV mutant sequences (IVS3-2A>G, and/or the del6.4 kb) and optionally wildtype sequences in the same assay using probes with labeled with detectable labels, amplification with a DNA polymerase and acquisition of fluorescence in real time. The assay is automated, high throughput and cost effective, since two mutations and a wildtype sequence can be detected in a single reaction, as opposed to separate reactions.

    摘要翻译： 本发明提供了一种用于在使用具有可检测标记的标记的探针的相同测定中检测粘液状脂血症IV突变体序列（IVS3-2A> G和/或del6.4kb）和任选的野生型序列的简单高通量测定， DNA聚合酶和实时荧光获取。 该测定是自动化，高通量和成本有效的，因为在单独的反应中可以检测到两个突变和野生型序列，而不是单独的反应。

    Digital filter system
    42.
    发明授权
    Digital filter system 失效
    数字滤波系统

    公开(公告)号：US5856934A

    公开(公告)日：1999-01-05

    申请号：US827407

    申请日：1997-03-27

    申请人： Michio Nakajima ,  Weimin Sun

    发明人： Michio Nakajima ,  Weimin Sun

    IPC分类号： H03H17/02 ,  G06F17/10

    CPC分类号： H03H17/0294

    摘要： Constants {P.sub.b00i, Q.sub.b00j, . . . , P.sub.ak2i, Q.sub.ak2j, P.sub.ci, Q.sub.cj, P.sub.di, and Q.sub.dj } for calculating each of filter coefficients {a.sub.k1, a.sub.k2, b.sub.00, b.sub.k1, b.sub.k2, c and d} for a digital filter 15 by using non-linear polynomials for pass band position data x and pass band width data y are stored in a memory 13. The constants {P.sub.b00i, Q.sub.b00j, . . . , P.sub.ak2i, Q.sub.ak2j, P.sub.ci, Q.sub.cj, P.sub.di, and Q.sub.dj } are determined by using the least square method so that the sum of the square of the errors between the filter coefficients calculated by using non-liner polynomials and the filter coefficients of digital filter having known characteristics becomes the least or the minimum. A CPU 11 calculates the filter coefficients non-linearly by using the constants stored in the memory 13, and sets the results to the digital filter 15 when new pass band position data x or pass band width data y is input at knobs SC and SW.

    摘要翻译： 常数{Pb00i，Qb00j，。 。 。 ，Pak2i，Qak2j，Pci，Qcj，Pdi和Qdj}，用于通过使用用于通带位置的非线性多项式来计算数字滤波器15的滤波器系数{ak1，ak2，b00，bk1，bk2，c和d} 数据x和通带宽度数据y存储在存储器13中。常数{Pb00i，Qb00j，...， 。 。 ，Pak2i，Qak2j，Pci，Qcj，Pdi和Qdj}通过使用最小二乘法确定，使得通过使用非线性多项式计算的滤波器系数与数字滤波器的滤波器系数之间的误差的平方和之和 已知特征变得最小或最小。 CPU 11通过使用存储在存储器13中的常数非线性地计算滤波器系数，并且当在通过旋钮SC和SW处输入新的通带位置数据x或通带宽度数据y时，将结果设置为数字滤波器15。

    Adaptive and morphological system for discriminating P-waves and R-waves inside the human body
    44.
    发明授权
    Adaptive and morphological system for discriminating P-waves and R-waves inside the human body 失效
    用于辨别人体内P波和R波的自适应和形态系统

    公开(公告)号：US5755739A

    公开(公告)日：1998-05-26

    申请号：US759902

    申请日：1996-12-04

    申请人： Weimin Sun ,  Pamela A. Abshire ,  Eric J. Panken ,  William J. Combs

    发明人： Weimin Sun ,  Pamela A. Abshire ,  Eric J. Panken ,  William J. Combs

    IPC分类号： A61B5/0452 ,  A61N1/368 ,  A61N1/37 ,  A61N1/362 ,  A61B5/0464

    CPC分类号： A61N1/3704 ,  A61B5/04525 ,  A61N1/368

    摘要： The present invention is a method and apparatus for processing a sensed atrial electrogram in conjunction with a sensed ventricular electrogram. The present invention permits accurate discrimination of atrial P-waves from far field ventricular events such as far field R-waves and avoids oversensing such far field ventricular events as atrial sense events and undersensing atrial events occurring within a fusion beat masked by a far field ventricular event in the atrial electrogram. Atrial channel trigger signals are generated in response to sensed P-waves and far field R-waves in the atrial electrogram, and ventricular trigger signals are generated in response to sensed R-waves in the ventricular electrogram. In response to each ventricular channel trigger signal, the sensed atrial electrogram signal is adaptively filtered for an adaptive filter time window only to remove the far field R-wave signal from the sensed atrial electrogram signal while avoiding adaptive filtering of the sensed atrial electrogram signal at other times. In response to each atrial channel trigger signal, the adaptively filtered, sensed atrial electrogram signal is subjected to morphological analysis in respect of a morphological model of a P-wave only during a morphology time window. In this manner, P-waves in the sensed atrial electrogram signal are detected and far field R-waves in the sensed atrial electrogram signal are not mistakenly detected as P-waves, while morphological analysis of the sensed atrial electrogram at other times is avoided.

    摘要翻译： 本发明是一种结合感测的心室电描记图处理感测的心房电描记图的方法和装置。 本发明允许从远场心室事件（例如远场R波）中准确地辨别心房P波，并避免过度监测诸如心房感觉事件的远场心室事件以及在由远场心室掩蔽的融合搏动内发生的低度心房事件 心房电图中的事件。 响应于心房电描记图中的感测到的P波和远场R波产生心房通道触发信号，并且响应于心室电图中的感测到的R波而产生心室触发信号。 响应于每个心室通道触发信号，感测的心房电描记信号被自适应滤波以用于自适应滤波器时间窗口，仅从感测的心房电描记图信号中去除远场R波信号，同时避免对感测的心房电描记图信号的自适应滤波 其他时候。 响应于每个心房通道触发信号，仅在形态学时间窗口期间，自适应滤波感应的心房电描记信号就P波的形态学模型进行形态学分析。 以这种方式，检测到感测的心房电描记信号中的P波，并且将感测到的心房电描记信号中的远场R波未被错误地检测为P波，同时避免了其他时间的感测的心房电描记图的形态学分析。

    90-degree phase shift network, system for controlling a 90-degree phase shift characteristic of the network, linearizer using all-pass filters, and system for controlling the linearizer
    45.
    发明授权
    90-degree phase shift network, system for controlling a 90-degree phase shift characteristic of the network, linearizer using all-pass filters, and system for controlling the linearizer 失效
    90度相移网络，用于控制网络的90度相移特性的系统，使用全通滤波器的线性化器，以及用于控制线性化的系统

    公开(公告)号：US5691929A

    公开(公告)日：1997-11-25

    申请号：US754583

    申请日：1996-11-21

    申请人： Weimin Sun

    发明人： Weimin Sun

    IPC分类号： H03H17/08 ,  G06F17/10

    CPC分类号： H03H17/08

    摘要： A 90-degree digital phase shift network includes at least two all-pass digital filters which have a phase difference of 90 degrees therebetween. These digital filters are adapted to receive the same signal. Each of the all-pass digital filters has phase characteristics .theta. (.omega.) given by ##EQU1## where T represents a sampling period, P.sub.i a real number indicative of a filter coefficient, .omega. the angular frequency, m a weight variable, n'=n/2 (n=even number), n'=(n+1)/2 (n=odd number), n an order of a 90-degree digital PSN, m being a positive value other than 1, and satisfying .vertline.2m.omega..vertline. / .vertline.P.sub.i .vertline.

    摘要翻译： 90度数字相移网络包括至少两个在其间具有90度相位差的全通数字滤波器。 这些数字滤波器适于接收相同的信号。 每个全通数字滤波器具有由给出的相位特性theta（ω），其中T表示采样周期，Pi表示滤波器系数的实数，ω是角频率，ma权重变量，n'= n / 2（n =偶数），n'=（n + 1）/ 2（n =奇数），n为90度数字PSN的顺序，m为除1以外的正值，满足| 2m 欧米茄| 当|ω足够小于1时，| | Pi | <1，同时满足|-Piω2T| 当omega T基本上等于pi时，/ 2m <1。

    Wireless communications systems and methods
    46.
    发明授权
    Wireless communications systems and methods 有权
    无线通信系统和方法

    公开(公告)号：US09088446B1

    公开(公告)日：2015-07-21

    申请号：US13411510

    申请日：2012-03-02

    申请人： Matthew C. Bromberg ,  Dale A. Branlund ,  Weimin Sun

    发明人： Matthew C. Bromberg ,  Dale A. Branlund ,  Weimin Sun

    IPC分类号： H04L25/03

    CPC分类号： H04B7/0851 ,  H04B7/0617 ,  H04B17/345 ,  H04L1/0071 ,  H04L25/0234 ,  H04L25/03 ,  H04L25/03949

    摘要： Methods and systems that enhance interference cancellation in communication channels are described. Specialized time domain training sequences and simple cross correlation are used to obtain a channel estimate for use in stacked carrier beamforming and OFDM based spatial beamforming. In certain embodiments, a time domain preamble sequence is provided as an alternative to the conventional frequency domain preamble sequence. The use of a time domain preamble can increase channel estimation performance, facilitating cancellation of co-channel interference. Embodiments include generating a training sequence preamble in the time domain, computing a frequency domain response of the channel using an estimate of its time domain impulse response, and using the frequency domain response of the channel to calculate channel estimation from a cross correlation of data received from the channel against the training sequence.

    摘要翻译： 描述了在通信信道中增强干扰消除的方法和系统。 使用专门的时域训练序列和简单的互相关来获得用于堆叠载波波束成形和基于OFDM的空间波束形成中的信道估计。 在某些实施例中，提供时域前导序列作为常规频域前导序列的替代。 使用时域前导码可以增加信道估计性能，有助于消除同信道干扰。 实施例包括在时域中生成训练序列前同步码，使用其时域脉冲响应的估计来计算信道的频域响应，并且使用信道的频域响应来从接收到的数据的互相关计算信道估计 从渠道反对训练序列。

    METHOD TO DETECT REPEAT SEQUENCE MOTIFS IN NUCLEIC ACID
    48.
    发明申请
    METHOD TO DETECT REPEAT SEQUENCE MOTIFS IN NUCLEIC ACID 有权
    检测核酸中重复序列运动的方法

    公开(公告)号：US20130115595A1

    公开(公告)日：2013-05-09

    申请号：US13576740

    申请日：2011-02-04

    申请人： Feras Hantash ,  Weimin Sun ,  David C. Tsao ,  Dana Marie Root ,  Charles M Strom

    发明人： Feras Hantash ,  Weimin Sun ,  David C. Tsao ,  Dana Marie Root ,  Charles M Strom

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/683 ,  C12Q1/6858 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/10 ,  C12Q2525/151 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2537/16

    摘要： Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5′-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample.

    摘要翻译： 提供了FMR1基因中存在或不存在CGG重复序列的扩增存在或不存在的方法，其中FMR2基因中CCG重复序列的扩增存在或不存在。 该方法可用于鉴定由于在5'-非翻译区域中CGG重复和CCG重复的扩增，FMR1基因和FMR2基因的正常/中间，相对于前体或全突变等位基因的个体。 该方法还可用于筛选脆性X综合征的新生儿或筛选妇女以确定CCG重复道全部前体的杂合状态。 这些方法在估算前遗症和全突变载体频率以及估计人群中FXTAS和FXPOI的患病率方面也很有用。 方法简单，快速，需要少量样品。

    SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER
    49.
    发明申请
    SELF-CALIBRATING RATE-ADAPTIVE PACEMAKER 失效
    自校准率自适应贴片机

    公开(公告)号：US20120004696A1

    公开(公告)日：2012-01-05

    申请号：US13230563

    申请日：2011-09-12

    申请人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang ,  Donald Hopper

    发明人： Weimin Sun ,  Bruce R. Jones ,  Douglas J. Lang ,  Donald Hopper

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365 ,  A61N1/36585

    摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

    摘要翻译： 一种用于自动调整速率适应性心脏起搏器的操作参数的系统和方法。 按照该方法，以周期性的间隔测量患者获得的最大功耗水平并存储。 然后可以使用存储的最大消耗水平来更新长期最大消耗水平，并且调整速率 - 响应曲线的斜率以将更新的长期最大消耗水平映射到最大允许起搏速率。 存储的最大消耗电平也可用于更新用于调整速率响应曲线的斜率的传感器目标速率。