公开(公告)号：US20250085276A1

公开(公告)日：2025-03-13

申请号：US18830071

申请日：2024-09-10

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Ronald Graham

IPC: G01N33/542 ,  G01N33/569

Abstract: Disclosed herein, inter alia, are methods and compositions useful for serially detecting multiple biological targets.

公开(公告)号：US20230193361A1

公开(公告)日：2023-06-22

申请号：US18050688

申请日：2022-10-28

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Ronald Graham ,  Michael Krause

IPC: C12Q1/6818 ,  C12Q1/6825

CPC classification number: C12Q1/6818 ,  C12Q1/6825 ,  G01N2458/00

Abstract: Disclosed herein, inter alia, are modified nucleotides and methods of using the same in nucleic acid sequencing reactions.

公开(公告)号：US20230119408A1

公开(公告)日：2023-04-20

申请号：US17887289

申请日：2022-08-12

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Surya Adhikari ,  Ada Tong ,  Zachary Terranova

IPC: C12Q1/6874 ,  C07H19/10

Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.

公开(公告)号：US20230002436A1

公开(公告)日：2023-01-05

申请号：US17365361

申请日：2021-07-01

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Surya Adhikari ,  Rodrigo Rodriguez ,  Zachary Terranova

IPC: C07H19/10 ,  C07H19/14 ,  C12Q1/6869 ,  C12N9/12

Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.

公开(公告)号：US20220267603A1

公开(公告)日：2022-08-25

申请号：US17737899

申请日：2022-05-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US20190352508A1

公开(公告)日：2019-11-21

申请号：US16415700

申请日：2019-05-17

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B11/24 ,  C09B69/00

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

公开(公告)号：US20190077726A1

公开(公告)日：2019-03-14

申请号：US16130783

申请日：2018-09-13

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Andrew Spaventa

IPC: C07B59/00 ,  C07H19/02 ,  C07H23/00 ,  C07H1/00 ,  C07H21/00

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of synthesizing labeled nucleosides.