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120 条记录 (耗时 0.049 秒)

    Nucleotide sequences coding for the pknB gene
    41.
    发明授权
    Nucleotide sequences coding for the pknB gene 失效

    公开(公告)号：US06939692B2

    公开(公告)日：2005-09-06

    申请号：US09949970

    申请日：2001-09-12

    申请人： Brigitte Bathe ,  Stephan Hans ,  Mike Farwick ,  Thomas Hermann

    发明人： Brigitte Bathe ,  Stephan Hans ,  Mike Farwick ,  Thomas Hermann

    IPC分类号： C12N9/12 ,  C12P13/04

    CPC分类号： C12N9/1205 ,  C12P13/04 ,  C12Y207/01037

    摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

    Alleles of the rel gene from coryneform bacteria
    43.
    发明授权
    Alleles of the rel gene from coryneform bacteria 有权
    来自棒状细菌的rel基因的等位基因

    公开(公告)号：US08293514B2

    公开(公告)日：2012-10-23

    申请号：US12781230

    申请日：2010-05-17

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Georg Thierbach

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Georg Thierbach

    IPC分类号： C12N9/12

    CPC分类号： C12P13/08 ,  A23L33/135 ,  A23L33/175 ,  C12N9/1235 ,  C12P13/04

    摘要： An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.

    摘要翻译： 棒状细菌的分离突变体，其包含编码具有GTP-焦磷酸激酶活性的多肽的基因，其中所述多肽包含氨基酸序列，其中除了L-脯氨酸以外的蛋白原氨基酸之一存在于位置38或相应的 或相当的地位。 此外，描述了编码具有GTP焦磷酸激酶酶活性的多肽的分离的多核苷酸，包含分离的多核苷酸的载体，包含载体的重组微生物和制备重组棒状杆菌型细菌的方法。 还描述了过表达GTP焦磷酸激酶的方法，制备L-氨基酸的方法，包含L-赖氨酸的L-赖氨酸和包含L-色氨酸的饲料。

    ALLELES OF THE GND GENE FROM CORYNEFORM BACTERIA
    46.
    发明申请
    ALLELES OF THE GND GENE FROM CORYNEFORM BACTERIA 失效
    来自CORYNEFORM BACTERIA的GND基因的病毒

    公开(公告)号：US20080131903A1

    公开(公告)日：2008-06-05

    申请号：US12016728

    申请日：2008-01-18

    申请人： Georg THIERBACH ,  Brigitte Bathe ,  Natalie Schischka

    发明人： Georg THIERBACH ,  Brigitte Bathe ,  Natalie Schischka

    IPC分类号： C12Q1/68 ,  C12P13/22 ,  C12P13/08

    CPC分类号： C12P13/22 ,  C12N9/0006 ,  C12P13/08 ,  C12P13/227

    摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.

    摘要翻译： 本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产 氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。