公开(公告)号：US06861227B2

公开(公告)日：2005-03-01

申请号：US10078059

申请日：2002-02-20

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/715 ,  G01N33/53 ,  C07K16/28

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7155

摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.

摘要翻译： 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地，本发明涉及一种编码新型人多肽的多核苷酸，命名为“细胞因子受体共同伽马链样”或“CRCGCL”。 本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07205139B2

公开(公告)日：2007-04-17

申请号：US10894043

申请日：2004-07-20

申请人： Paul A. Moore ,  Steven M. Ruben ,  Reinhard Ebner

发明人： Paul A. Moore ,  Steven M. Ruben ,  Reinhard Ebner

IPC分类号： C12N9/48 ,  C12N9/68 ,  C12N1/21 ,  C12N5/06 ,  C12N15/63 ,  C07H21/04

CPC分类号： C12N9/6456 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/6421 ,  C12N2799/026 ,  Y10S530/827 ,  Y10S530/828

摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.

摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。

公开(公告)号：US06815534B2

公开(公告)日：2004-11-09

申请号：US10057951

申请日：2002-01-29

申请人： Paul A. Moore ,  Steven M. Ruben ,  Reinhard Ebner

发明人： Paul A. Moore ,  Steven M. Ruben ,  Reinhard Ebner

IPC分类号： C07K1640

CPC分类号： C12N9/6456 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/6421 ,  C12N2799/026 ,  Y10S530/827 ,  Y10S530/828

摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.

摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。

公开(公告)号：US06372473B1

公开(公告)日：2002-04-16

申请号：US09411977

申请日：1999-10-04

申请人： Paul A. Moore ,  Steven M. Ruben ,  Reinhard Ebner

发明人： Paul A. Moore ,  Steven M. Ruben ,  Reinhard Ebner

IPC分类号： C12N948

CPC分类号： C12N9/6456 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/6421 ,  C12N2799/026 ,  Y10S530/827 ,  Y10S530/828

摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.

摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。

公开(公告)号：US20090197278A9

公开(公告)日：2009-08-06

申请号：US12036846

申请日：2008-02-25

申请人： Paul A. Moore ,  Reiner L. Gentz ,  Henry Hongjun Ji ,  Jian Ni ,  Jing-Shan Hu ,  Craig A. Rosen

发明人： Paul A. Moore ,  Reiner L. Gentz ,  Henry Hongjun Ji ,  Jian Ni ,  Jing-Shan Hu ,  Craig A. Rosen

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12P21/04 ,  C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.

摘要翻译： 公开了编码此类多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。

公开(公告)号：US20080227110A1

公开(公告)日：2008-09-18

申请号：US12036846

申请日：2008-02-25

申请人： Paul A. Moore ,  Reiner L. Gentz ,  Henry Hongjun Ji ,  Jian Ni ,  Jing-Shan Hu ,  Craig A. Rosen

发明人： Paul A. Moore ,  Reiner L. Gentz ,  Henry Hongjun Ji ,  Jian Ni ,  Jing-Shan Hu ,  Craig A. Rosen

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12P21/04 ,  C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.

摘要翻译： 公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。

公开(公告)号：US06903072B2

公开(公告)日：2005-06-07

申请号：US09345373

申请日：1999-07-01

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N1/21

CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US07335489B2

公开(公告)日：2008-02-26

申请号：US10453478

申请日：2003-06-04

申请人： Paul A. Moore ,  Reiner L. Gentz ,  Henry Hongjun Ji ,  Jian Ni ,  Jing-Shan Hu ,  Craig A. Rosen

发明人： Paul A. Moore ,  Reiner L. Gentz ,  Henry Hongjun Ji ,  Jian Ni ,  Jing-Shan Hu ,  Craig A. Rosen

IPC分类号： C07K14/35 ,  C12N15/00 ,  C12N5/00 ,  C12N1/20 ,  C07H21/04 ,  C07H21/02 ,  C07K14/435

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.

摘要翻译： 公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。

公开(公告)号：US07232667B2

公开(公告)日：2007-06-19

申请号：US10733311

申请日：2003-12-12

申请人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

发明人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

IPC分类号： C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C07K14/50

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US06916786B2

公开(公告)日：2005-07-12

申请号：US10075446

申请日：2002-02-15

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N1/20 ,  C12N5/10

CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.