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    HYDROPHOBIC ACTIVE AGENT PARTICLE COATINGS AND METHODS FOR TREATMENT
    42.
    发明申请
    HYDROPHOBIC ACTIVE AGENT PARTICLE COATINGS AND METHODS FOR TREATMENT 审中-公开

    公开(公告)号：US20180169305A1

    公开(公告)日：2018-06-21

    申请号：US15842110

    申请日：2017-12-14

    Applicant: Surmodics, Inc.

    Inventor： Joram Slager ,  Rick Murphy

    IPC: A61L29/16 ,  A61L29/08

    Abstract: Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.

    LUBRICIOUS INSERTION TOOLS FOR MEDICAL DEVICES AND METHODS FOR USING
    45.
    发明申请
    LUBRICIOUS INSERTION TOOLS FOR MEDICAL DEVICES AND METHODS FOR USING 审中-公开

    公开(公告)号：US20180078744A1

    公开(公告)日：2018-03-22

    申请号：US15704765

    申请日：2017-09-14

    Applicant: SURMODICS, Inc.

    Inventor： Amy Trocke ,  Gregg Sutton ,  Joram Slager

    IPC: A61M25/10

    CPC classification number: A61M25/1002 ,  A61M25/0097 ,  A61M25/0668 ,  A61M39/06 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2025/1079 ,  A61M2025/1081 ,  A61M2205/6081

    Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body, and that can provide advantages in terms of balloon insertion, safety, and drug delivery. The insertion tool includes a tubular portion that accommodates a balloon portion of a balloon catheter, and one or more separation margin(s) in the wall of the tubular portion or one or more split(s) in the tubular wall. The insertion tool also includes a proximal tab that extends from a second lengthwise half having a portion at an angle skew to the lengthwise axis, or that is in the form of a solid article comprising a concave surface that is fastened to an outer surface of the second lengthwise half of the tubular portion; or first and second tabs that extend from first and second lengthwise halves of the tubular portion, respectively.

    SOLVENT METHODS FOR PREPARING CRYSTALLINE MACROLIDE PARTICULATES, COMPOSITIONS, AND ARTICLES CONTAINING PARTICULATES
    46.
    发明申请
    SOLVENT METHODS FOR PREPARING CRYSTALLINE MACROLIDE PARTICULATES, COMPOSITIONS, AND ARTICLES CONTAINING PARTICULATES 审中-公开

    公开(公告)号：US20180071436A1

    公开(公告)日：2018-03-15

    申请号：US15714298

    申请日：2017-09-25

    Applicant: SURMODICS, Inc.

    Inventor： Joram Slager ,  Aleksey V. Kurdyumov ,  Toni M. Heyer

    IPC: A61L29/16 ,  A61K9/14 ,  C07D498/18

    CPC classification number: A61L29/16 ,  A61K9/0019 ,  A61K9/14 ,  A61K31/436 ,  A61L2300/416 ,  C07D498/18 ,  Y10T428/2982

    Abstract: The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20 μm or less, or 10 μm or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process. Particulates display desirable low polydispersity, and can be used in therapeutic compositions, or can be associated with an implantable or insertable medical device for the treatment of a subject.

    TWO-PART INSERTION TOOL AND METHODS
    49.
    发明申请
    TWO-PART INSERTION TOOL AND METHODS 审中-公开

    公开(公告)号：US20170281907A1

    公开(公告)日：2017-10-05

    申请号：US15467554

    申请日：2017-03-23

    Applicant: Surmodics, Inc.

    Inventor： Bruce M. Jelle ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Nathan A. Lockwood

    IPC: A61M25/06 ,  A61M25/00

    Abstract: Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

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